Anti-inflammatory and antinociceptive activities of Phyllanthus niruri spray-dried standardized extract

Porto, Cínthia R. C.; Soares, Luiz Alberto Lira; Souza, Tatiane Pereira de; Petrovick, Pedro Ros; Lyra, Ibson L.; Júnior, Raimundo F. Araújo; Langassner, Silvana Maria Zucolotto; Ferreira, Aurigena A. A.; Guerra, Gerlane Coelho Bernardo

doi:10.1590/s0102-695x2013000100019

Cited by 4 publications

(4 citation statements)

References 25 publications

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“…The anti-inflammatory activity of meniran is evidenced by a decrease in oedema volume in the treatment group by 58% which is greater than the positive control (indomethacin), which only has an oedema reduction effect of 43% (Sumarny et al, 2013). Anti-inflammatory is produced because meniran is rich in phenolic compounds, especially flavonoids, namely quercetin (Porto et al, 2013). Due to the content of phytoconstituents in meniran, such as flavonoids, steroids, triterpenoids, saponins, and tannins, there is another pharmacological effect, namely as an antiulcer as evidenced in the study of Mostofa et al, (2017), where methanol extract of meniran has a potential effect as an antiulcer at a dose of 400 mg /kg by comparison with the standard drug, namely omeprazole.…”

Section: Phyllanthus Niruri Lmentioning

confidence: 99%

Literature Review of the Pharmacological Activities of the Euphorbiaceae Family Plants

Naki¹,

Abdullah

Susilawati

2023

JFSP

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Euphorbiaceae family plants are spread in Indonesia and empirically, have been used for a long time as medicine. This article review aims to discuss the pharmacological activities of several plants from the Euphorbiaceae family. This research was conducted by conducting a literature review limited to research in the form of scientific articles. The scientific article in question results from research reviewed and published in Indonesian and English. The steps in the search are divided into several stages, starting from identification, screening, eligibility, and data grouping. The articles used in this article review were obtained by searching the internet from online data search media/search engines such as Google/Google Scholar and journal provider sites such as PubMed, NCBI, and SINTA with the keywords "Euphorbiaceae plants," "Ethnopharmacology, "Ethnobotany and Ethnopharmacy," "Plant Activity and Effectiveness," "Euphorbiaceae family activity," and "Pharmacological activity of Euphorbiaceae. After determining the keywords, the next step is filtering multiple data or duplications and filtering the article's title, abstract, and keywords so that data can be determined to be used or not for the following review.This study is a literature review based on several national or international scientific articles about the pharmacological activity of Euphorbiaceae plants. The literature study found that some plants from the Euphorbiaceae family have pharmacological activities, and the most dominant are antimicrobial, antioxidant, and anti-inflammatory. Moreover, many other activities include analgesic, antipyretic, antithrombotic, anti-hypercholesterolemia, antihyperglycemic, antihistamine, diuretic, and antiseptic.

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Section: Phyllanthus Niruri Lmentioning

confidence: 99%

Literature Review of the Pharmacological Activities of the Euphorbiaceae Family Plants

Naki¹,

Abdullah

Susilawati

2023

JFSP

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“…It is identified in Amazon rainforest and other tropical areas, including South East Asia, Southern India, and China. P. niruri L. has been extensively reported in traditional and folk medication systems such as Ayurveda and Siddha to treat various diseases including diabetes mellitus, jaundice, asthma, joint pain, immunomodulator, loss of appetite, constipation, injuries, as antimicrobial, conjunctivitis, gonorrheal diseases of males and females, inflammatory diseases, skin itching, kidney stones or failures, and urogenital disease [4][5][6][7][8][9][10][11][12][13][14][15][16]. Curative properties of P. niruri are due to the presence of polyphenols, include classes of chromones, coumarins, lignans, stilbenes, xanthones, and flavonoid [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Neuropharmacological Study of Phyllanthus Niruri in Swiss Albino Mice

Nagaraj

Saravanan

Mani

2021

Asian J Pharm Clin Res

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Objective: The objective of this study is to evaluate the neurological, behavioral, and autonomic changes of Phyllanthus niruri in Swiss albino mice using Irwin’s method. Methods: A total of 24 mice was divided into four groups of six each (3-male, 3-female in each group). Aqueous extract of P. niruri was prepared. Based on body weight aqueous extract was given to the mice by orally through gavage tube (Group I – 300 mg/kg, Group II – 600 mg/kg, Group III – 900 mg/kg, and Group IV – 1200 mg/kg). Neuropharmacological profile is studied for each mice using Irwin’s observational test, the mice were observed for 4 h after oral administration for various behavioral, neurological, and autonomic changes at 0, 1, 2, 3, 4 h. Results: P. niruri showed negligible actions at 300 mg/kg and 600 mg/kg body weight. At 900 mg/kg and 1200 mg/kg P. niruri showed certain behavioral and neuronal changes. P. niruri increased alertness, stereotypy, restlessness, irritability/aggressiveness in behavioral profile indicating that the drug is a CNS stimulant. Furthermore, it showed mild tremors in neurological profile indicating CNS excitation. Conclusion: Aqueous extract of P. niruri at 900 mg/kg and 1200 mg/kg showed changes in behavioral profile, neurological profile, showing it as CNS stimulant properties. Since it is an observational study further research should be done to explore CNS stimulant properties in various in vivo studies.

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“…Extracts of this herb have been proven to have therapeutic effects in many preclinical studies. Phyllanthus niruri has been reported to be an effective anti-inflammatory [ 12 ], analgesic [ 13 ], gastroprotective [ 14 ], anti-diabetic [ 15 ], hepatoproctive [ 16 – 18 ], anti-malarial [ 19 , 14 ] and antispasmodic [ 20 ]. In Bangladesh, P. niruri grows all over the country.…”

Section: Introductionmentioning

confidence: 99%

“…In Bangladesh, P. niruri grows all over the country. According to a previous study, the aerial part of this plant has been reported for its anti-inflammatory activity [ 12 ]. Besides, it has been stated that the leaves of P. niruri contain profound amount of flavonoids and polyphenolics [ 21 ] which possess significant activity against inflammation and ulcer [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of anti-inflammatory and gastric anti-ulcer activity of Phyllanthus niruri L. (Euphorbiaceae) leaves in experimental rats

Mostofa

Ahmed

Begum

et al. 2017

BMC Complement Altern Med

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BackgroundThe medicinal plants signify a massive basin of potential phytoconstituents that could be valuable as a substitute to allopathic drugs or considered as an analogue in drug development. Phyllanthus niruri L. (Euphorbiaceae) is generally used in traditional medicine to treat ulcer and inflammation. In this project we investigated the methanolic extract of leaves of Phyllanthus niruri for anti-inflammatory and anti-ulcer activity.MethodsThe anti-inflammatory activity of methanol extract of Phyllanthus niruri leaves was evaluated at the doses of 100, 200 and 400 mg/kg, p.o. while using ibuprofen (20 mg/kg, p.o) as the standard drug. The animals used were Swiss albino rats. Inflammation was induced by injecting 0.1 ml carrageenan (1% w/v) into the left hind paw. Paw tissues from the different groups were examined for inflammatory cell infiltration. On the other hand, antiulcer activity of methanolic extract of P. niruri leaves at the doses of 100, 200 and 400 mg/kg, p.o. were examined against ethanol-acid induced gastric mucosal injury in the Swiss albino rats - keeping omeprazole (20 mg/kg, p.o.) as reference. The rats were dissected and the stomachs were macroscopically examined to identify hemorrhagic lesions in the glandular mucosa.Results P. niruri significantly (p < 0.01) decreased carrageenan-induced paw edema; it exhibited a reduction of 46.80%, 55.32% and 69.14% at doses of 100, 200 and 400 mg/kg, respectively. These findings were further supported by the histological study. The methanolic extract also disclosed good protective effect against ethanol-acid induced gastric mucosal injury in the rats. Administration of the extract’s doses (100, 200 and 400 mg/kg) demonstrated a significant (p < 0.01) reduction in the ethanol- acid induced gastric erosion in all the experimental groups when compared to the control. The methanolic extract at the higher dose (400 mg/kg) resulted in better inhibition of ethanol-acid induced gastric ulcer as compare to omeprazole (20 mg/kg). Histological studies of the gastric wall revealed that toxic control rats revealed mucosal degeneration, ulceration and migration of numerous inflammatory cells throughout the section. On the other hand, MEPN treatment groups showed significant regeneration of mucosal layer and significantly prevented the formation of hemorrhage and edema.ConclusionsThe investigation suggests that methanolic extract of P. niruri leaf possess anti-inflammatory activity and promotes ulcer protection as ascertained by regeneration of mucosal layer and substantial prevention of the formation of hemorrhage and edema.

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Anti-inflammatory and antinociceptive activities of Phyllanthus niruri spray-dried standardized extract

Cited by 4 publications

References 25 publications

Literature Review of the Pharmacological Activities of the Euphorbiaceae Family Plants

Literature Review of the Pharmacological Activities of the Euphorbiaceae Family Plants

Neuropharmacological Study of Phyllanthus Niruri in Swiss Albino Mice

Evaluation of anti-inflammatory and gastric anti-ulcer activity of Phyllanthus niruri L. (Euphorbiaceae) leaves in experimental rats

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