Phyllanthus niruri L., Euphorbiaceae, spray-dried standardized extract was studied for its anti-infl ammatory and antinociceptive activities in adult albino rats and mice. The anti-infl ammatory effect of spray-dried standardized extract was observed in carrageenan-induced paw edema and thioglycolate-induced leukocyte migration, while antinociceptive effects were observed using Randall & Selitto, tail fl ick, and hot plate tests. This study showed that intraperitoneal spray-dried standardized extract at 100, 200, 800, or 1600 mg/kg reduced the vascular response in the infl ammatory process of paw edema induced by 1% carrageenan. Oral spray-dried standardized extract at 100 or 200 mg/kg inhibited leukocyte migration to the site of infl ammation induced by 3% thioglycolate. In rats, at 100 and 200 mg/kg intraperitoneally, the extract exhibited a marked peripheral analgesic effect in a Randall & Selitto assay and showed signifi cant central analgesic activity in a hot plate and tail fl ick assay. In conclusion, this study suggested that Phyllanthus niruri spray-dried standardized extract has potent infl ammatory and antinociceptive activities and that these activities are not modifi ed by standard drying process, making it feasible to use the dry extract standardized to obtain a phytotherapic preparation and thus validating its use for the treatment of pain and infl ammation disorders.