Anti-inflammatory and antinociceptive activity of taxoids and lignans from the heartwood of Taxus baccata L.

Küpeli, Esra; Erdemoğlu, N.; Yeşilada, Erdem; Şener, Bilge

doi:10.1016/j.jep.2003.09.005

Cited by 60 publications

(38 citation statements)

References 19 publications

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“…In fact, we showed that the inhibitory effect of extracts increases with the polarity of the solvent used. This is may be due to the presence of polar compounds such as lignans which are known for their anti-inflammatory activities [45]. When polar solvents were used for the extraction such as acetone and methanol, differences on inhibitory effect were observed between leaves and stems.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of Pro-inflammatory Secreted Phospholipase A2 by Extracts from Cynara cardunculus L.

Kammoun¹,

Koubaa²,

Ali³

et al. 2009

Appl Biochem Biotechnol

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The aim of the present work was to evaluate the anti-inflammatory properties of Cynara cardunculus L. (Asteraceae) during its growth using various solvents such as n-hexane, dichloromethane, acetone, and methanol for air-dried leaves and stems. The anti-inflammatory activities of crude extracts were evaluated by measuring the inhibition potency of mammalian non-pancreatic phospholipases A2 (hG-IIA). The methanol and acetone extracts of leaves harvested in February exhibit potent inhibition of hG-IIA (IC(50) = 50 and 70 microg/ml, respectively). However, the acetone extract of stems harvested in December inhibits the hG-IIA with a lower IC(50) around 130 microg/ml. Fractionation on silica gel and hydrophobic gel of the methanol extract of leaves harvested in February increases the inhibitory effect, and the IC(50) reached 10 microg/ml.

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Section: Discussionmentioning

confidence: 99%

Inhibition of Pro-inflammatory Secreted Phospholipase A2 by Extracts from Cynara cardunculus L.

Kammoun¹,

Koubaa²,

Ali³

et al. 2009

Appl Biochem Biotechnol

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“…Lignans represent an abundant and widespread group of compounds demonstrating a wide range of biological activities, such as anticancer (review by Landete 2012), antimicrobial, anti-inflammatory (Küpeli et al 2003;During et al 2012), hypoglycemic (Banskota et al 2006; reviews by: Erdemoglu et al 2004;Saleem et al 2005;Topcu and Demirkiran 2007;Dar and Arumugam 2013), antioxidant (Masuda et al 2010), cardioprotective (Zanwar et al 2011) and anti-osteoporotic (Yin et al 2006). Lignan food ingredients such as secoisolariciresinol, matairesinol, lariciresinol and pinoresinol are conversed by intestinal bacteria to enterolignans: enterodiol and enterolactone and were reported to reduce the risk of some cancers and cardiovascular diseases (Milder et al 2007;Ghisalberti 1997;Landete 2012) and exhibited estrogen activity (Cassidy et al 2000;Aehle et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Lignan accumulation in two-phase cultures of Taxus x media hairy roots

Sykłowska-Baranek

Łysik

Jeziorek

et al. 2018

Plant Cell Tiss Organ Cult

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The biosynthetic potential for six lignans accumulation in two lines of Taxus x media hairy roots was investigated. The cultures of KT and ATMA hairy root lines were supplemented with precursors: coniferyl alcohol (CA 1, 10 or 100 µM) and/or l-phenylalanine (100 µM PHEN) and/or methyl jasmonate (100 µM MeJa). Moreover the two-phase in vitro cultures supported with perfluorodecalin (PFD) as a gas carrier and in situ extrahent were used. The hairy root lines differed in lignan production profiles. In the control untreated cultures KT roots did not accumulate secoisolariciresinol and lariciresinol while ATMA roots did not accumulate matairesinol. In ATMA roots the treatment with CA (1 or 10 µM) resulted in the production of lariciresinol and secoisolariciresinol whereas solely lariciresinol was present after 100 µM CA application. Elicitation with 1 µM CA and MeJa yielded with hydroxymatairesinol aglyca and lariciresinol glucosides with their highest content 37.88 and 3.19 µg/g DW, respectively. The stimulatory effect of simultaneous treatment with 1 µM CA, PHEN and MeJa on lignan production was observed when the cultures were supplemented with PFD-aerated or degassed. In ATMA root cultures these applied conditions were the most favourable for matairesinol content which amounted to 199.86 and 160.25 µg/g DW in PFD-aerated and PFD-degassed supported cultures, respectively. In KT root cultures solely, hydroxymatairesinol and coniferin/CA content was enhanced with their highest yield 59.29 and 134.60 µg/g DW in PFD-aerated and PFD-degassed cultures, respectively.

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“…[70][71] These include: antitumor, antimitotic, antiviral, antimicrobial, antinociceptive antiulcerogenic activities, inhibition of certain enzymes, and carrageenan induced edema in mice. [72][73][74][75] Earlier studies have revealed the antiplasmodial potential of different classes of lignans including: furfuran against the chloroquine-resistant P. falciparum 76 and aryltetralone against P. berghei. 77 Other classes of lignans including: tetrahydrofuran lignans, neolignans, dibenzylbutanelignan and a coumarinolignan also demonstrated varying degrees of antimalarial activities against mainly P. falciparum with tetrahydrofuran-type sesquilignans revealing significant activities.…”

Section: Bioactivity Resultsmentioning

confidence: 99%

Antiplasmodial Activities of the Stem bark Extract and Compounds of Zanthoxylum gilletii (De wild) P.G. Waterman

Omosa¹,

Okemwa²

2017

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Introduction: Multidrug resistance remains a major obstacle hindering successful antimalarial chemotherapy. In the current study, 50% methanol in dichloromethane extract and six compounds from the stem bark of Zanthoxylum gilletii were explored for their antiplasmodial potential against three strains of Plasmodium falciparum. Materials and Methods: The extract was obtained by cold percolation using 50 % MeOH in CH 2 Cl 2 and the antiplasmodial activities were assayed using a non-radioactive Malaria SYBR Green I assay to determine a concentration that inhibits growth of 50% of parasites in culture (IC 50 ). Results and Discussion: Chromatographic separation of the crude extract yielded six known compounds including: one lignan, sesamin (1), an alkamide, fagaramide (2), three benzo [c] phenanthridine alkaloids, 8-acetonyldihydrochelerythrine (3), dihydrochelerythine (4), norchelerythrine (5) and one pentacyclic triterpenoid, lupeol (6). The extract and sesamin (1) showed promising antiplasmodial activities against the chloroquine resistant (W2), chloroquine sensitive (D6) and 3D7 strains of P. falciparum, with IC 50 values of 2.52, 1.48 and 1.43 µg/mL and 5.4, 9.1 and 8.3 µM, respectively. To the best of our knowledge, this is the first report on antiplasmodial activities of the stem bark extract (50%

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Anti-inflammatory and antinociceptive activity of taxoids and lignans from the heartwood of Taxus baccata L.

Cited by 60 publications

References 19 publications

Inhibition of Pro-inflammatory Secreted Phospholipase A2 by Extracts from Cynara cardunculus L.

Inhibition of Pro-inflammatory Secreted Phospholipase A2 by Extracts from Cynara cardunculus L.

Lignan accumulation in two-phase cultures of Taxus x media hairy roots

Antiplasmodial Activities of the Stem bark Extract and Compounds of Zanthoxylum gilletii (De wild) P.G. Waterman

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