Anti-inflammatory and antinociceptive effects of active ingredients in the essential oils from Gynura procumbens, a traditional medicine and a new and popular food material

Huang, Xialing; Li, Xiaojun; Qin, Qiu-Fang; Li, Yu-Sang; Zhang, Wei Kevin; Tang, He-Bin

doi:10.1016/j.jep.2019.111916

Cited by 44 publications

(31 citation statements)

References 22 publications

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“…It is known that monoterpenes, among which linalool, limonene, and linalyl acetate, representing the major constituents of BEO-FF, possess anti-inflammatory and analgesic capability [31,51,58,60,61]. Therefore, at least in part, the anti-inflammatory and analgesic effect of BEO-FF could be attributable to these compounds, although, in this study, we did not investigate which monoterpenes were responsible for these outcomes.…”

Section: Discussionmentioning

confidence: 84%

Mechanisms Underlying the Anti-Inflammatory Activity of Bergamot Essential Oil and Its Antinociceptive Effects

Lombardo

Cirmi

Musumeci

et al. 2020

Plants

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Renewed interest in natural products as potential source of drugs led us to investigate on both the anti-inflammatory and anti-nociceptive activity of Citrus bergamia Risso et Poiteau (bergamot) essential oil (BEO). Carrageenan-induced paw edema in rats was used as an experimental model of inflammation. Because of the toxicity of furocoumarins, we performed our study by using the BEO fraction deprived of these compounds (BEO-FF). Treatment with BEO-FF led to a significant inhibition of paw edema induced by a sub-plantar injection of carrageenan. Moreover, histological examination of BEO-FF-treated rat paw biopsies showed a reduction of pathological changes typical of edema. Pre-treatment with BEO-FF significantly reduced interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α levels in the paw homogenates, as well as nitrite/nitrate and prostaglandin E2 (PGE2) content in exudates. In addition, BEO-FF possesses antioxidant properties, as determined by cell-free assays. Furthermore, results of the writhing test showed that BEO-FF elicited a pronounced analgesic response, as demonstrated by a significant inhibition of constrictions in mice receiving acetic acid, with respect to control animals, whereas the results of the hot plate test suggested that the supra-spinal analgesia participates in the anti-nociceptive effect of BEO-FF. Our study indicates that BEO-FF exerts anti-inflammatory and anti-nociceptive effects, and suggests its potential role as an anti-edemigen and analgesic drug.

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Section: Discussionmentioning

confidence: 84%

Mechanisms Underlying the Anti-Inflammatory Activity of Bergamot Essential Oil and Its Antinociceptive Effects

Lombardo

Cirmi

Musumeci

et al. 2020

Plants

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“…Merr Specialty Natural Products Co. Ltd., Thailand + No Yes—HPLC, electrospray ionization time-of-flight mass spectrometry Shwter et al (2014) Gynura procumbens (Lour.) Merr Ethno Resources Sdn Bhd, Malaysia + No No Wong et al (2015) Gynura procumbens Green House Facility, Faculty of Science and Technology, Universiti Kebangsaan Malaysia (UKM) + No No Huang et al (2019) Gynura procumbens (Lour.) Merr Hainan Province, South China + No Yes—GC-MS Liu M. et al (2019) Gynura procumbens (Lour.)…”

Section: Resultsmentioning

confidence: 99%

“…A total of 17 selected studies ( Siriwatanametanon et al, 2010 ; Kim et al, 2011 ; Akowuah et al, 2012 ; Wu et al, 2013 ; Seow et al, 2014 ; Shwter et al, 2014 ; Chao et al, 2015 ; Wong et al, 2015 ; Yu et al, 2016 ; Yin et al, 2017 ; Yuandani et al, 2017 ; Rahman et al, 2018 ; Sukadeetad et al, 2018 ; Huang et al, 2019 ; Nazri et al, 2019 ; Ning et al, 2019 ; Chandradevan et al, 2020 ) provided the full information about the botanical material and authenticated the Gynura species by depositing voucher specimens. Six selected studies ( Iskander et al, 2002 ; Xu et al, 2015 ; Ma et al, 2017 ; Dong et al, 2019 ; Liu M. et al, 2019 ; Liu Y. et al, 2019 ) reported the information of the Gynura species source but did not provide voucher specimens.…”

Section: Resultsmentioning

confidence: 99%

“…Spectroscopic techniques, including UV, IR, and nuclear magnetic resonance (NMR), allow the quantitation of single or multiple compounds that share similarities in their UV absorbance, thus providing a more holistic view of herbal medicines in contrast to the quantitation of a single compound ( Upton et al, 2019 ). Chemical analysis of Gynura species were reported in studies conducted by Kim et al (2011) , Siriwatanametanon and Heinrich (2011) , Wu et al (2013) , Yu et al (2016) , Yuandani et al (2017) , Rahman et al (2018) , Sukadeetad et al (2018) , Dong et al (2019) , Huang et al (2019) , Liu M. et al (2019) , Liu Y. et al (2019) , Nazri et al (2019) , and Chandradevan et al (2020) using methods such as HP-TLC, HPLC, gas chromatography-mass spectrometer, electrospray ionization-mass spectrometry, electrospray ionization time-of-flight mass spectrometry, liquid chromatography with tandem mass spectrometry, ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry, 1 H N 13 C NMR, and 2D-NMR.…”

Section: Resultsmentioning

confidence: 99%

“…Of the 27 selected studies, there are seven species of genus Gynura , which are G. procumbens , G. bicolor , G segetum , G. divaricata , G. formosana , G. nepalensis , and G. pseudochina. Among these Gynura species, 11 out of 27 selected studies focused on G. procumbens ( Iskander et al, 2002 ; Kim et al, 2011 ; Akowuah et al, 2012 ; Shwter et al, 2014 ; Wong et al, 2015 ; Huang et al, 2019 ; Liu M. et al, 2019 ; Liu Y. et al, 2019 ; Nazri et al, 2019 ; Ning et al, 2019 ; Chandradevan et al, 2020 ), five studies on G. bicolor ( Wu et al, 2013 ; Chao et al, 2015 ; Yin et al, 2017 ; Pai et al, 2019 ; Yang et al, 2019 ), four studies on G. pseudochina ( Siriwatanametanon et al, 2010 ; Siriwatanametanon and Heinrich, 2011 ; Rerknimitr et al, 2016 ; Sukadeetad et al, 2018 ), two studies on G. segetum ( Seow et al, 2014 ; Yuandani et al, 2017 ), two studies on G. nepalensis ( Yu et al, 2016 ; Rahman et al, 2018 ), two studies on G. divaricata ( Xu et al, 2015 ; Dong et al, 2019 ), and one study on G. formosana ( Ma et al, 2017 ) .…”

Section: Resultsmentioning

confidence: 99%

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Antioxidant and Anti-Inflammatory Effects of Genus Gynura: A Systematic Review

et al. 2020

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Background:Gynura species have been used traditionally to treat various ailments, such as fever, pain, and to control blood glucose level. This systematic review critically discusses studies regarding Gynura species that exhibited antioxidant and anti-inflammatory effects, thus providing perspectives and instructions for future research of the plants as a potential source of new dietary supplements or medicinal agents.Methods: A literature search from internet databases of PubMed, Scopus, Science Direct, e-theses Online Service, and ProQuest was carried out using a combination of keywords such as “Gynura,” “antioxidant,” “anti-inflammatory,” or other related words. Research articles were included in this study if they were experimental (in vitro and in vivo) or clinical studies on the antioxidant or anti-inflammatory effects of Gynura species and if they were articles published in English.Results: Altogether, 27 studies on antioxidant and anti-inflammatory effects of Gynura species were selected. The antioxidant effects of Gynura species were manifested by inhibition of reactive oxygen species production and lipid peroxidation, modulation of glutathione-related parameters, and enzymatic antioxidant production or activities. The anti-inflammatory effects of Gynura species were through the modulation of inflammatory cytokine production, inhibition of prostaglandin E2 and nitric oxide production, cellular inflammatory-related parameters, and inflammation in animal models. The potential anti-inflammatory signaling pathways modulated by Gynura species are glycogen synthase kinase-3, nuclear factor erythroid 2-related factor 2, PPARγ, MAPK, NF-κB, and PI3K/Akt. However, most reports on antioxidant and anti-inflammatory effects of the plants were on crude extracts, and the chemical constituents contributing to bioactivities were not clearly understood. There is a variation in quality of studies in terms of design, conduct, and interpretation, and in-depth studies on the underlying mechanisms involved in antioxidant and anti-inflammatory effects of the plants are in demand. Moreover, there is limited clinical study on antioxidant and anti-inflammatory effects of Gynura species.Conclusion: This review highlighted antioxidant and anti-inflammatory effects of genus Gynura and supported their traditional uses to treat oxidative stress and inflammatory-related diseases. This review is expected to catalyze further studies on genus Gynura. However, extensive preclinical data need to be generated from toxicity and pharmacokinetic studies before clinical studies can be pursued for their development into clinical medicines to treat oxidative stress and inflammatory conditions.

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Longevity Spinach (Gynura procumbens) Ameliorated Oxidative Stress and Inflammatory Mediators in Cisplatin‐Induced Organ Dysfunction in Rats: Comprehensive in vivo and in silico Studies

Chandra Shill,

El‐Nashar,

Prova Mollick

et al. 2024

Chemistry & Biodiversity

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This study aimed to investigate the efficacy of Gynura procumbens (GP) leaf extract against cisplatin (CP)‐induced hepatorenal complications in Wister albino rats. Additionally, it aims to detect pol‐yphenolic compounds using high‐performance liquid chromatography with diode‐array detection (HPLC‐DAD). The rats were treated intraperitoneally with CP (7.5mg/kg) to mediate hepatorenal damage. They were then treated with GP extract (75 and 150mg/kg, P.O.) for 7 consecutive days. CP‐mediated hepatorenal biomarkers like alkaline phosphatase, alanine aminotransferase, aspar‐tate aminotransferase, creatinine and blood urea nitrogen levels were normalized by GP extract in a dose‐dependent manner. Similarly, it significantly reduced CP‐induced oxidative stress inducers including nitric oxide and advanced oxidative protein products. Besides, it enhanced the antioxi‐dant enzymes, and glutathione levels. Histopathological studies showed that CP caused collagen accumulation in the liver and kidney tissues. GP extract drained the collagen mass and acted against hepatorenal damage. Ellagic acid, gallic acid, quercetin hydrate, kaempferol, and rutin hydrate were revealed in GP extract. In‐silico modelling showed good docking scores of the polyphenolic compounds with molecular targets including CYP4502E1, NF‐κB, caspase‐3, and TNF‐α. GP could be an effective therapeutic option for management of anticancer drugs’ complications like CP‐induced organ damage, although clinical studies are required to establish herbal formulation.

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Anti-inflammatory and antinociceptive effects of active ingredients in the essential oils from Gynura procumbens, a traditional medicine and a new and popular food material

Cited by 44 publications

References 22 publications

Mechanisms Underlying the Anti-Inflammatory Activity of Bergamot Essential Oil and Its Antinociceptive Effects

Mechanisms Underlying the Anti-Inflammatory Activity of Bergamot Essential Oil and Its Antinociceptive Effects

Antioxidant and Anti-Inflammatory Effects of Genus Gynura: A Systematic Review

Longevity Spinach (Gynura procumbens) Ameliorated Oxidative Stress and Inflammatory Mediators in Cisplatin‐Induced Organ Dysfunction in Rats: Comprehensive in vivo and in silico Studies

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