Anti-inflammatory, and antinociceptive effects of Campomanesia adamantium microencapsulated pulp

Viscardi, Danieli Zuntini; Oliveira, Vinícius Soares de; Arrigo, Jucicléia da Silva; Piccinelli, Ana Claudia; Cardoso, Cláudia Andréa Lima; Maldonade, Iriani Rodrigues; Kassuya, Cândida Aparecida Leite; Sanjinez-Argandoña, Eliana Janet

doi:10.1016/j.bjp.2016.09.007

Cited by 19 publications

(12 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The C. adamantium, common in the Cerrado region, is already known to be rich in flavonoids and glycoflavonoids, and it is the chromatographic profile in TLC (Table 3) and in HPLC at 254 nm confirm that the etanolic extract of the leaves of these species has flavonoids at retention times 22.7 minutes, common for flavones in 34.5 minutes, the latter being common for chacons (Viscardi et al, 2016). The G. americana is one rubiaceae recognized for presented iridoids, but no peakes were observed below 8 minutes (Ono et al, 2005).…”

Section: Discussionmentioning

confidence: 78%

Toxicity and phytochemistry of eight species used in the traditional medicine of sul-mato-grossense, Brazil

et al. 2020

View full text Add to dashboard Cite

The Brazilian Cerrado has several botanical species for medicinal purposes used by traditional communities and many of these plants are not included in the list of Medicinal Plants Research Program of Central Medicines. The purpose of this study was the phytochemical screening and toxicology bioassay front of Brine shrimp L. of ethanolic extracts of eight species of plants used in folk medicine of Campo Grande, Mato Grosso do Sul, Brazil. The ethanolic extracts were submitted to phytochemical screening, determination of phenolic compounds and flavonoids. Toxicological assays were carried front of Brine shrimp according to standard methodology. The analysis TLC and HPLC-DAD confirmed the predominance of phenolic compounds and derivatives, specifically for the quercetin. The most toxic was the C. affinis DC. with death at all concentrations, the A. humile A. St. Hil. showed no mortality and the other species showed intermediate toxicity. The extracts of the investigated species are rich in phenolic compounds and derivatives, specifically quercetin, and feature toxicity between moderate to high, a fact that requires attention, since much of the traditional communities rely on herbal drugs in its raw form with preventive and curative purpose, meeting the basic health care.

show abstract

Section: Discussionmentioning

confidence: 78%

Toxicity and phytochemistry of eight species used in the traditional medicine of sul-mato-grossense, Brazil

et al. 2020

View full text Add to dashboard Cite

show abstract

“…by gavage before exposure to one of the aforementioned inflammatory stimuli. The groups treated with dexamethasone by the subcutaneous route (s.c.) before receiving carrageenan or CFA were used as the "positive control," as the literature has demonstrated its efficacy in decreasing inflammatory and pain parameters in mice 33–35 . The negative controls received a vehicle before the inoculation of either of the inflammatory stimuli mentioned.…”

Section: Methodsmentioning

confidence: 99%

“…The groups treated with dexamethasone by the subcutaneous route (s.c.) before receiving carrageenan or CFA were used as the "positive control," as the literature has demonstrated its efficacy in decreasing inflammatory and pain parameters in mice. [33][34][35] The negative controls received a vehicle before the inoculation of either of the inflammatory stimuli mentioned. In two of the experimental models evaluated, a group named "naive" received only isotonic saline, instead of botryosphaeran or dexamethasone, and were inoculated with sterile isotonic saline instead of the inflammatory stimuli.…”

Section: Significance Statementmentioning

confidence: 99%

Oral administration of botryosphaeran [(1 → 3)(1 → 6)‐β‐d‐glucan] reduces inflammation through modulation of leukocytes and has limited effect on inflammatory nociception

Silva

Pereira

Santos

et al. 2022

Cell Biochemistry & Function

View full text Add to dashboard Cite

Several biological activities of the fungal exopolysaccharide (1 → 3)(1 → 6) -β-D-glucan (botryosphaeran) have been described in the literature, but its effects on inflammation have not been evaluated. This study aimed to investigate the action of botryosphaeran on experimental mice models of carrageenan-induced acute pleurisy and acute paw edema, and complete Freund's adjuvant-induced persistent paw edema. All botryosphaeran doses tested (1.0, 2.5, 5.0, and 10.0 mg/kg birth weight [b.w.], orally administered) reduced leukocyte recruitment, nitric oxide (NO) levels, and protein extravasation in the pleural cavity. Botryosphaeran (5 mg/kg b.w.) did not diminish edema and mechanical hyperalgesia in the paw within 4 h; however, cold allodynia was alleviated within the first 2 h. In the persistent paw inflammation model, the effects of daily oral administration of botryosphaeran (5 mg/kg b.w.) were evaluated over 3 and 7 days. The fungal β-glucan significantly reduced the levels of the cytokines, tumor necrosis factor(TNF)-α, interleukin (IL)-6), and IL-10, in the paw homogenates in both protocols, while paw edema and the levels of advanced oxidation protein products (AOPP) only diminished on Day 7. No effect in mechanical hyperalgesia was observed. Oral treatment for 3 or 7 days also decreased the plasma levels of NO, AOPP, TNF-α, and IL-10. On Day 7, the number of leukocytes in the blood was also reduced by this treatment. Importantly, botryosphaeran did not induce inflammation in mice when administered alone over 7 days. This study demonstrated the anti-inflammatory and antinociceptive potential of botryosphaeran in these experimental models, making this fungal β-glucan a new possibility for complementary treating acute and chronic inflammation.

show abstract

“…They have a succulent pulp with an acid-sweet flavor and are generally harvested in the field and consumed fresh (Oliveira;Costa & Proença, 2020). Among the main biological activities investigated in the species are: antimicrobial activity (Sá et al, 2018), antioxidant (Coutinho et al, 2010), anti-inflammatory and anti-nociceptive (Viscardi et al, 2017).…”

Section: Campomanesia Adamantiummentioning

confidence: 99%

Scientometric analysis of scientific production on the genus Campomanesia Ruiz & Pav. (Myrtaceae) and most studied species - research trends involving native Brazilian plants

Steckelberg

Paula

Romano

et al. 2022

RSD

View full text Add to dashboard Cite

Brazil has rich biodiversity, harboring native plants with potential for medicinal use, including species of the Campomanesia genus. Although public policies to encourage phytotherapy advocate the best use of plant biodiversity, most species listed in official forms and monographs are exotic species. Thus, the aim of this study is to identify research trends involving the Campomanesia and main species, using scientometric tools, so that, by viewing and knowing the scientific production on the genus and species of pharmacological interest, possibilities for research with native species so that they can be integrated into Brazilian’s unified health system (SUS). The research resulted in 302 publications up to September 2021. Bibliometric analyzes on genus were then carried out with data from the WoS platform and social network analysis through of scientometric mapping, using the Vosviewer (VOS) application. Species of the genus with more than 10 publications indexed in WoS were also analyzed. Brazil leads research on the genus and C. xanthocarpa (120/302); C. adamantium (70/302); C. pubescens (33/120); C.phaea (25/302); C. lineatifolia (21/302) and C. guazumifolia (10/302) were the species with the highest publication volume. It is the first work that analyzes the scientific production on these genus of Myrtaceae family and the aforementioned species, which revealed itself a promising field of research, yet little explored, which might encourage new studies aimed at better use of Brazilian biodiversity and the safe and effective use of native plants that may bring benefits to people's health and well-being.

show abstract

Anti-inflammatory, and antinociceptive effects of Campomanesia adamantium microencapsulated pulp

Cited by 19 publications

References 21 publications

Toxicity and phytochemistry of eight species used in the traditional medicine of sul-mato-grossense, Brazil

Toxicity and phytochemistry of eight species used in the traditional medicine of sul-mato-grossense, Brazil

Oral administration of botryosphaeran [(1 → 3)(1 → 6)‐β‐d‐glucan] reduces inflammation through modulation of leukocytes and has limited effect on inflammatory nociception

Scientometric analysis of scientific production on the genus Campomanesia Ruiz & Pav. (Myrtaceae) and most studied species - research trends involving native Brazilian plants

Contact Info

Product

Resources

About