Anti-inflammatory and antioxidant effect of cerium dioxide nanoparticles immobilized on the surface of silica nanoparticles in rat experimental pneumonia

Serebrovska, Zoya; Swanson, R. James; Portnichenko, Volodymyr I.; Shysh, Angela; Павлович, Сучков Юрий; Tumanovska, Lesya V.; Dorovskych, A.; Lysenko, V. S.; Тертых, В. А.; Bolbukh, Yuliia; Dosenko, Victor

doi:10.1016/j.biopha.2017.05.064

Cited by 57 publications

(37 citation statements)

References 35 publications

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“…Our results showed that NC modulate the inflammatory response, decreasing VCAM‐1 surface exposure, involved in the leukocyte recruitment, and the release of cytokines, IL‐6 and IL‐8. These findings are consistent with those of previous studies that have shown a protective effect of NC on oxidative and inflammatory response …”

Section: Discussionsupporting

confidence: 94%

“…These findings are consistent with those of previous studies that have shown a protective effect of NC on oxidative and inflammatory response. [57][58][59][60][61] Previous studies demonstrated that a disturbance of the oxidative balance may lead to premature senescence associated with telomere shortening. 62,63 There is little information on the effects of nanomaterials on oxidative stress-induced senescence in human cells.…”

Section: Discussionmentioning

confidence: 99%

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Effects of cerium oxide nanoparticles on hemostasis: Coagulation, platelets, and vascular endothelial cells

Turco

Ciofani

Cappello

et al. 2019

J Biomedical Materials Res

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Cerium oxide nanoparticles (nanoceria [NC]) have attracted much attention in biomedicine due to their surface composition that confers interesting redox activities and regenerative properties. Studies have demonstrated that the application of NPs in biomedicine can influence components of hemostatic system, inducing blood clotting, alterations of blood cells, and endothelial cell functions. NC were tested in vitro to assess their hemocompatibility and anticoagulant, anti‐inflammatory, and anti‐senescence activity in human endothelial cells. Hemocompatibility has been evaluated in vitro looking at the impact of NC on coagulation times, fibrinogen, and platelet aggregation. The effect of NC on vascular endothelial cells were assayed by testing cell viability, antioxidant activity, anticoagulant (tissue factor [TF]‐mRNA expression) and anti‐inflammatory properties (VCAM‐1 exposure, cytokine release), and senescence (telomere shortening). NC did not show significant effects on coagulation process, hemolysis, or platelet aggregation. In endothelial cells, NC did not affect cell viability, reduced oxidative stress, inhibited mRNA‐TF expression, VCAM‐1 expression, and cytokine release. Moreover, NC reduce telomere shortening, possibly counteracting premature senescence. The hemocompatibility combined with anticoagulant and anti‐inflammatory phenotype and the ability of counteract the premature senescence in vascular cells make NC a promising therapeutic tool in oxidative stress‐related conditions. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2019.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Effects of cerium oxide nanoparticles on hemostasis: Coagulation, platelets, and vascular endothelial cells

Turco

Ciofani

Cappello

et al. 2019

J Biomedical Materials Res

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“…32 On the other hand, CNPs were known as antioxidants because of their dual redox states on the surface. [33][34][35] Antioxidants could be harmful per se, because of pro-oxidant activity. [36][37][38] For example, Srinivas et al suggested that acute exposure of CNPs through inhalation route may induce cytotoxicity via oxidative stress and may lead to a chronic inflammatory response.…”

Section: Discussionmentioning

confidence: 99%

<p>Antioxidant and toxicity studies of biosynthesized cerium oxide nanoparticles in rats</p>

Khorrami

Sadeghnia

Pasdar

et al. 2019

IJN

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Purpose The purpose of this study was to investigate the acute toxic potential of cerium oxide nanoparticles (CNPs) synthesized by pullulan in adult male Wistar rats. Patients and methods Thirty male Wistar rats randomly were divided into five experimental groups of six animals each. The animals were received 50, 100, 200, and 400 mg/kg CNPs for 14 consecutive days. At the end of the experiment, the rats were euthanized and histopathological evaluation of the liver and renal tissues, as well ass, the markers of serum oxidative stress including thiobarbituric acid reactive substances, total sulfhydryl content, and antioxidant capacity (using ferric reducing/antioxidant power assay) were assessed. Hematological parameters and the activity of liver function enzymes were also measured. Results The results of this study showed that CNPs caused no significant changes in the activity of liver enzymes, hepatic and renal histopathology and hematological parameters, while significantly improved serum redox status. Conclusion Acute administration of pullulan-mediated CNPs is safe and possess antioxidant activity.

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“…Nanoceria has an ability to scavenge free radicals, or ROS, and inhibit the production of inflammatory mediator 93. Serebrovska et al engineered a combined material in which Ce NPs were immobilized on the surface of SiO 2 , showing antiinflammatory and antioxidant effects 94. Similarly, a novel Fe 3 O 4 /CeO 2 core–shell theranostic NP was designed with the capability of reacting with ROS and being detected by magnetic resonance imaging.…”

Section: Nanotherapeutics Of Ra Based On Nanodrugsmentioning

confidence: 99%

Recent Advances in Nanotheranostics for Treat‐to‐Target of Rheumatoid Arthritis

Wang

Meng

et al. 2020

Adv Healthcare Materials

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Early diagnosis, standardized treatment, and regular monitoring are the clinical treatment principle of rheumatoid arthritis (RA). The overarching principles and recommendations of treat‐to‐target (T2T) in RA advocate remission as the optimum aim, especially for patients with very early disease who are initiating therapy with anti‐RA medications. However, traditional anti‐RA drugs cannot selectively target the inflammatory areas and may cause serious side effects due to its short biological half‐life and poor bioavailability. These limitations have significantly driven the research and application of nanomaterial‐based drugs in theranostics of RA. Nanomedicines have appropriate sizes and easily modified surfaces which can enhance their biological compatibility and prolong circulation time of drug‐loading systems in vivo. Traditional T2T regimens cannot evaluate the efficacy of drugs in real time, while clinical drug nanosizing can realize the integration of diagnosis and treatment of RA. This review bridges clinically proposed T2T concepts and nanomedicine in an integrated system for RA early‐stage diagnosis and treatment. The most advanced progress in various nanodrug delivery systems for theranostics of RA is summarized, establishing a clear path and a new perspective for further optimization of T2T. Finally, the key facing challenges are discussed and prospects are addressed.

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Anti-inflammatory and antioxidant effect of cerium dioxide nanoparticles immobilized on the surface of silica nanoparticles in rat experimental pneumonia

Cited by 57 publications

References 35 publications

Effects of cerium oxide nanoparticles on hemostasis: Coagulation, platelets, and vascular endothelial cells

Effects of cerium oxide nanoparticles on hemostasis: Coagulation, platelets, and vascular endothelial cells

<p>Antioxidant and toxicity studies of biosynthesized cerium oxide nanoparticles in rats</p>

Recent Advances in Nanotheranostics for Treat‐to‐Target of Rheumatoid Arthritis

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