Anti-inflammatory and antioxidant effects of a hypoglycemic fructan fraction from Psacalium peltatum (H.B.K.) Cass. in streptozotocin-induced diabetes mice

Alarcón-Aguilar, Francisco Javier; Fortis-Barrera, Ángeles; Ángeles-Mejía, S.; Banderas-Dorantes, Tania; Jasso-Villagomez, E.I.; Almanza-Perez, Julio César; Blancas-Flores, Gerardo; Zamilpa, Alejandro; Díaz‐Flores, Margarita; Román-Ramos, Rubén

doi:10.1016/j.jep.2010.08.003

Cited by 23 publications

(15 citation statements)

References 42 publications

(45 reference statements)

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“…1 They are disseminated from the south of the United States to Guatemala and some of them are used in folk medicine to cure diabetes and renal, hepatic, gastrointestinal and dermatological problems. 2,3 The hypoglycemic, anti-inflammatory and antioxidant activities of P. decompositum, [4][5][6] P. peltatum 7,8 and P. radulifolium 9 extracts have been reported. The antimicrobial effects of P. radulifolium 10 and the antiinflammatory properties of P. sinuatum 11 have also been determined.…”

Section: Introductionmentioning

confidence: 99%

“…The antimicrobial effects of P. radulifolium 10 and the antiinflammatory properties of P. sinuatum 11 have also been determined. Sesquitepenes mainly of eremophilane and modified eremophilane types are the main secondary metabolites isolated from the eight species of the genus chemically studied so far: P. decompositum [4][5][6] (also studied as Cacalia decomposita), 12,13 P. tussilaginoides (studied as Cacalia ampulacea), 13 P. peltatum, 7,8 P. sinuatum,…”

Section: Introductionmentioning

confidence: 99%

“…17,18 As continuation of our research on Senecioneae we studied the chemical composition of P. cirsiifolium which to the best of our knowledge has no previous studies. We report the isolation of fourteen modified eremophilane derivatives (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14), of which four (1-4) are described for the first time. Two known caryophyllenes (16,18), one aromadendrene (17) and one flavonoid (15) were also isolated ( Figure 1).…”

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confidence: 99%

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Modified eremophilanes and anti-inflammatory activity of Psacalium cirsiifolium

Arciniegas¹,

Pérez-Castorena²,

Nieto‐Camacho³

et al. 2013

J. Braz. Chem. Soc.

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Quatro novos eremofilanos modificados, juntamente com dez derivados conhecidos de cacalol, dois cariofilenos, um aromadendreno e um flavonoide foram purificados a partir de Psacalium cirsiifolium. As estruturas destes compostos foram elucidadas por análise espectroscópica. A atividade anti-inflamatória dos extratos e de sete dos compostos isolados foi avaliada no modelo de 12-O-tetradecanoilforbol-13-acetato (TPA) de inflamação aguda induzida. O composto inédito 2a-hidroxiadenostin B (4) mostrou uma atividade dependente da dose (IC 50 0,41 mmol por orelha) e um efeito de inibição de neutrófilos medido pelo teste de mieloperoxidase (MPO) semelhante ao efeito da indometacina, 0,31 e 1,0 mmol por orelha.Four new modified eremophilanes, together with ten known cacalol derivatives, two caryophyllenes, one aromadendrene and one flavonoid were isolated from Psacalium cirsiifolium. The structures of these compounds were elucidated by spectroscopic analysis. The antiinflammatory activity of extracts and of seven of the isolated compounds was evaluated on 12-O-tetradecanoylphorbol-13-acetate (TPA) model of induced acute inflammation. The new compound 2a-hydroxyadenostin B (4) showed a dose dependent activity (IC 50 0.41 mmol per ear) and a neutrophil inhibition effect as measured by the myeloperoxidase (MPO) assay similar to that of indomethacin at 0.31 and 1.0 mmol per ear.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Modified eremophilanes and anti-inflammatory activity of Psacalium cirsiifolium

Arciniegas¹,

Pérez-Castorena²,

Nieto‐Camacho³

et al. 2013

J. Braz. Chem. Soc.

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“…Increases glucose uptake and the activation of PPARγ [109] 75 Psacalium peltatum Asteraceae Streptozotocin mice ND [110] 76 Psidium guajava Myrtaceae FL83B mouse hepatocytes Increases glucose uptake [111] 77 Pterocarpus marsupium Leguminosae Diabetic C57BL/6 mice Diabetic and fructose-fed diabetic rats…”

Section: Cornus Officinalismentioning

confidence: 99%

“…Carbohydrate fraction [110] 24 Psidium guajava Vescalagin [111] 25 Ratanhiae radix Ratanhiaphenol III [83] 26 Rehmannia glutinosa Oligosaccharides [116,117] 27 Sambucus nigra Naringenin [120] 28…”

Section: Psacalium Peltatummentioning

confidence: 99%

Antidiabetic plants improving insulin sensitivity

Eddouks¹,

Bidi²,

Bouhali³

et al. 2014

Journal of Pharmacy and Pharmacology

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Background Globally, the prevalence of diabetes mellitus is increasing at an alarming rate. This chronic pathology gravely troubled the human health and quality of life. Both insulin deficiency and insulin resistance are involved in the pathophysiology of diabetes mellitus. Moreover, insulin resistance is being diagnosed nowadays in a growing population of diabetic and obese patients, especially in industrialized societies. There are lots of conventional agents available to control and to treat diabetes, but total recovery from this disorder has not been reported up to this date. Plants provided a potential source of hypoglycemic drugs and are widely used in several traditional systems of medicine to prevent diabetes. A few reviews with less attention paid to mechanisms of action have been published on antidiabetic plants. Objectives The present review focuses on the various plants that have been reported to be effective in improving insulin sensitivity associated with diabetes. Key findings In this work, an updated systematic review of the published literature has been conducted to review the antidiabetic plants improving insulin sensitivity and 111 medicinal plants have been reported to have a beneficial effect on insulin sensitivity using several in-vitro and in-vivo animal models of diabetes. Conclusion The different metabolic and cellular effects of the antidiabetic plants improving insulin sensitivity are reported indicating the important role of medicinal plants as potential alternative or complementary use in controlling insulin resistance associated with diabetes mellitus.

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Effects of Different Sources of Fructans on Body Weight, Blood Metabolites and Fecal Bacteria in Normal and Obese non-diabetic and Diabetic Rats

Rendón-Huerta

Juárez-Flores

Pinos-Rodríguez

et al. 2011

Plant Foods Hum Nutr

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Fructans contribute significantly to dietary fiber with beneficial effects on gastrointestinal physiology in healthy individuals and offer a promising approach to treating some diseases. Two experiments (Experiment 1 = rats with normal weight; Experiment 2 = obese rats) were developed to compare the effects of three fructan sources (Cichorium intybus L. Asteraceae, Helianthus tuberosus L. Asteraceae and Agave angustifolia ssp. tequilana Haw, Agavaceae) on body weight change, blood metabolites and fecal bacteria in non-diabetic (ND) and diabetic (D) rats. In Experiment 1 total body weight gain and daily feed intake in D and ND rats decreased (P < 0.05) with supplements of fructan. Only in D rats, blood glucose concentrations, fecal Clostrodium spp. counts, and liver steatosis decreased, while blood HDL concentrations and fecal Lactobacillus spp. and Bifidobacterium spp. counts increased due to fructans. In Experiment 2, total body weight gain and feed intake in ND and D rats were also decreased by fructans. In ND rats, fructan decreased blood glucose concentrations. In D rats, fructans from A. angustifolia ssp. tequilana decreased blood cholesterol and LDL and liver steatosis. For both ND and D rats, fecal Lactobacillus spp. and Bifidobacterium spp. counts were higher (P < 0.05) with fructan supplements.

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Anti-inflammatory and antioxidant effects of a hypoglycemic fructan fraction from Psacalium peltatum (H.B.K.) Cass. in streptozotocin-induced diabetes mice

Cited by 23 publications

References 42 publications

Modified eremophilanes and anti-inflammatory activity of Psacalium cirsiifolium

Modified eremophilanes and anti-inflammatory activity of Psacalium cirsiifolium

Antidiabetic plants improving insulin sensitivity

Effects of Different Sources of Fructans on Body Weight, Blood Metabolites and Fecal Bacteria in Normal and Obese non-diabetic and Diabetic Rats

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