Effects of Different Sources of Fructans on Body Weight, Blood Metabolites and Fecal Bacteria in Normal and Obese non-diabetic and Diabetic Rats

Rendón-Huerta, Juan A.; Juárez-Flores, Bertha I.; Pinos-Rodríguez, Juan Manuel; Aguirre‐Rivera, Juan Rogelio; Delgado-Portales, Rosa E.

doi:10.1007/s11130-011-0266-9

Cited by 58 publications

(36 citation statements)

References 36 publications

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“…Additional characterization of bacterial crossfeeding via in vitro models and computational simulations will also help advance our understanding of the role of diet on the microbiome. Because rodent studies have provided evidence for the benefits of agave inulin supplementation on body composition, blood cholesterol, and blood glucose concentrations (45)(46)(47), further investigation is warranted to determine whether these effects translate into health benefits in human populations.…”

Section: Discussionmentioning

confidence: 99%

“…In vitro experimentation has demonstrated that agave inulin is readily fermented by bifidobacteria and lactobacilli (43,44). In addition, rodent studies have provided evidence that the botanical origin and chemical structure of different inulin-type fibers (e.g., agave inulin and chicory inulin) induce variable effects on body composition, blood cholesterol, and blood glucose concentrations (45)(46)(47). The prebiotic effects of agave inulin in healthy adults, however, are currently unknown.…”

Section: Introductionmentioning

confidence: 99%

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Agave Inulin Supplementation Affects the Fecal Microbiota of Healthy Adults Participating in a Randomized, Double-Blind, Placebo-Controlled, Crossover Trial1–3

Holscher¹,

Bauer²,

Gourineni³

et al. 2015

The Journal of Nutrition

134

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Agave Inulin Supplementation Affects the Fecal Microbiota of Healthy Adults Participating in a Randomized, Double-Blind, Placebo-Controlled, Crossover Trial1–3

Holscher¹,

Bauer²,

Gourineni³

et al. 2015

The Journal of Nutrition

134

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“…However, the microbial mechanisms remain in unclear [12,13]. New molecular techniques that enable analysis of non-cultivable bacteria are starting to be applied in studies investigating the impact of prebiotics on the cecal microbiota.…”

Section: Introductionmentioning

confidence: 99%

Modulation of Gut Microbiota of Overweight Mice by Agavins and Their Association with Body Weight Loss

Huazano-García

Shin

López

2017

Preprint

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Abstract:Agavins consumption has lead to accelerate body weight loss in mice. We investigated the changes on cecal microbiota and short chain fatty acids (SCFA) associated to body weight loss in overweight mice. Firstly, mice were fed with standard (ST5) or high fat (HF5) diet for 5 weeks. Secondly, overweight mice were shifted to standard diet alone (HF-ST10) or supplemented with agavins (HF-ST+A10) or oligofructose (HF-ST+O10), five more weeks. Cecal contents were collected before and after supplementation to determine microbiota and SCFA concentrations. At the end of first phase, HF5 mice showed a significant increase of body weight, which was associated with reduction of cecal microbiota diversity (PD whole tree; non-parametric t-test, P < 0.05), increased Firmicutes/Bacteroidetes ratio and reduced SCFA concentrations (t-test, P < 0.05). After diet shifted, HF-ST10 normalized its microbiota, increase its diversity and SCFA levels, whereas agavins (HF-ST+A10) or oligofructose (HF-ST+O10) led to partial microbiota restoration, with normalization of the Firmicutes/Bacteroides ratio as well as higher SCFA levels (P < 0.1). Moreover, agavins noticeably enriched Klebsiella and Citrobacter (LDA > 3.0); this enrichment has not been reported previously under a prebiotic treatment. In conclusion, agavins or oligofructose modulated cecal microbiota composition, reduced extent of diversity and increased SCFA. Furthermore, identification of bacteria enriched by agavins, opens opportunities to explore new probiotics.

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“…Growing evidence showed that the physicochemical properties of dietary fiber such as viscosity, water-binding capacity, and fermentability may contribute to decrease the food intake in human beings and rodents [3,4,5]. Viscous fibers increase chewing activity and saliva production in the mouth [6], which could result in early satiation and reduced food intake [7,8].…”

Section: Introductionmentioning

confidence: 99%

Soluble Fiber with High Water-Binding Capacity, Swelling Capacity, and Fermentability Reduces Food Intake by Promoting Satiety Rather Than Satiation in Rats

et al. 2016

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To understand whether soluble fiber (SF) with high water-binding capacity (WBC), swelling capacity (SC) and fermentability reduces food intake and whether it does so by promoting satiety or satiation or both, we investigated the effects of different SFs with these properties on the food intake in rats. Thirty-two male Sprague-Dawley rats were randomized to four equal groups and fed the control diet or diet containing 2% konjac flour (KF), pregelatinized waxy maize starch (PWMS) plus guar gum (PG), and PWMS starch plus xanthan gum (PX) for three weeks, with the measured values of SF, WBC, and SC in the four diets following the order of PG > KF > PX > control. Food intake, body weight, meal pattern, behavioral satiety sequence, and short-chain fatty acids (SCFAs) in cecal content were evaluated. KF and PG groups reduced the food intake, mainly due to the decreased feeding behavior and increased satiety, as indicated by decreased meal numbers and increased inter-meal intervals. Additionally, KF and PG groups increased concentrations of acetate acid, propionate acid, and SCFAs in the cecal contents. Our results indicate that SF with high WBC, SC, and fermentability reduces food intake—probably by promoting a feeling of satiety in rats to decrease their feeding behavior.

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Effects of Different Sources of Fructans on Body Weight, Blood Metabolites and Fecal Bacteria in Normal and Obese non-diabetic and Diabetic Rats

Cited by 58 publications

References 36 publications

Agave Inulin Supplementation Affects the Fecal Microbiota of Healthy Adults Participating in a Randomized, Double-Blind, Placebo-Controlled, Crossover Trial1–3

Agave Inulin Supplementation Affects the Fecal Microbiota of Healthy Adults Participating in a Randomized, Double-Blind, Placebo-Controlled, Crossover Trial1–3

Modulation of Gut Microbiota of Overweight Mice by Agavins and Their Association with Body Weight Loss

Soluble Fiber with High Water-Binding Capacity, Swelling Capacity, and Fermentability Reduces Food Intake by Promoting Satiety Rather Than Satiation in Rats

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