Anti-inflammatory and antioxidant properties of rice bran oil extract in copper sulfate-induced inflammation in zebrafish (Danio rerio)

Liu, Naicheng; Zhang, Peng; Xue, Mingyang; Zhang, Mengjie; Xiao, Zidong; Xu, Chuncheng; Fan, Yuding; Liu, Wei; Wu, Yeying; Wu, Minxian; Zhang, Qinghua; Zhou, Yong

doi:10.1016/j.fsi.2023.108740

Cited by 5 publications

(4 citation statements)

References 50 publications

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“…Furthermore, type 2 diabetes is categorized as an inflammatory disease [ 39 ]. Given our previous results demonstrating tocotrienol’s anti-inflammatory capacity, it can be inferred that tocotrienol may exert an anti-inflammatory function by reducing the metabolism of arachidonic acid [ 4 ]. It is worth noting that lipid deposition can increase sphingolipids [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

“…The cycling conditions were as follows: 30 s of initial denaturation at 95 °C, 40 cycles consisting of 30 s at 95 °C and 30 s at 60 °C, and a final melting curve program. The gene expression levels were calculated by the 2 −ΔΔCt method [ 4 ].…”

Section: Methodsmentioning

confidence: 99%

“…However, a common issue observed in intensive aquaculture practices is the excessive deposition of lipids in the liver, leading to fatty livers among fish populations. This surplus adipose tissue alters numerous biological pathways [ 3 ] and weakens fish immunity, making the organism more susceptible to inflammatory responses [ 4 ]. It also affects fish metabolism, reducing their disease resistance [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

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Hypolipidemic Effect of Rice Bran Oil Extract Tocotrienol in High-Fat Diet-Induced Hyperlipidemia Zebrafish (Danio Rerio) Induced by High-Fat Diet

Liu,

Zhang,

Xue

et al. 2024

IJMS

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In recent years, the potent influence of tocotrienol (T3) on diminishing blood glucose and lipid concentrations in both Mus musculus (rats) and Homo sapiens (humans) has been established. However, the comprehensive exploration of tocotrienol’s hypolipidemic impact and the corresponding mechanisms in aquatic species remains inadequate. In this study, we established a zebrafish model of a type 2 diabetes mellitus (T2DM) model through high-fat diet administration to zebrafish. In the T2DM zebrafish, the thickness of ocular vascular walls significantly increased compared to the control group, which was mitigated after treatment with T3. Additionally, our findings demonstrate the regulatory effect of T3 on lipid metabolism, leading to the reduced synthesis and storage of adipose tissue in zebrafish. We validated the expression patterns of genes relevant to these processes using RT-qPCR. In the T2DM model, there was an almost two-fold upregulation in pparγ and cyp7a1 mRNA levels, coupled with a significant downregulation in cpt1a mRNA (p < 0.01) compared to the control group. The ELISA revealed that the protein expression levels of Pparγ and Rxrα exhibited a two-fold elevation in the T2DM group relative to the control. In the T3-treated group, Pparγ and Rxrα protein expression levels consistently exhibited a two-fold decrease compared to the model group. Lipid metabolomics showed that T3 could affect the metabolic pathways of zebrafish lipid regulation, including lipid synthesis and decomposition. We provided experimental evidence that T3 could mitigate lipid accumulation in our zebrafish T2DM model. Elucidating the lipid-lowering effects of T3 could help to minimize the detrimental impacts of overfeeding in aquaculture.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hypolipidemic Effect of Rice Bran Oil Extract Tocotrienol in High-Fat Diet-Induced Hyperlipidemia Zebrafish (Danio Rerio) Induced by High-Fat Diet

Liu,

Zhang,

Xue

et al. 2024

IJMS

Self Cite

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“…The use of these compounds is common due to their high safety and lack of toxicity [104]. These chemical compounds have biological activities beneficial to humans, including anti-inflammatory [105], anticancer [106], prevention and treatment of diabetes [107], and beneficial effects on the immune system [108]. Antioxidants act by inhibiting free radical reactions, suppressing oxidative processes, and avoiding consequent cell damage [109].…”

Section: Packaging With Active Antioxidant Propertymentioning

confidence: 99%

Agar-Agar and Chitosan as Precursors in the Synthesis of Functional Film for Foods: A Review

et al. 2023

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The food industry produces an exorbitant amount of solid waste of petrochemical origin as a result of the increase in the development of new products. Natural polymers are an alternative to this theme; however, their development with adequate properties is a challenge. The union of different polymers in the synthesis of packaging is usually carried out to improve these properties. The combination of agar-agar and chitosan biopolymers show particular advantages through hydrogen bonds and electrostatic attraction between oppositely charged groups, presenting a promising source of studies for the synthesis of green packaging. When combined with natural extracts with active properties, these polymers allow an increase in the microbiological stability of foods associated with lower chemical preservative content and greater environmental sustainability.

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Effect of wogonin, an active ingredient of Scutellariae Radix, on fish infected with Aeromonas hydrophila

Cui,

Zeng,

Guan

et al. 2024

Aquacult Int

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Anti-inflammatory and antioxidant properties of rice bran oil extract in copper sulfate-induced inflammation in zebrafish (Danio rerio)

Cited by 5 publications

References 50 publications

Hypolipidemic Effect of Rice Bran Oil Extract Tocotrienol in High-Fat Diet-Induced Hyperlipidemia Zebrafish (Danio Rerio) Induced by High-Fat Diet

Hypolipidemic Effect of Rice Bran Oil Extract Tocotrienol in High-Fat Diet-Induced Hyperlipidemia Zebrafish (Danio Rerio) Induced by High-Fat Diet

Agar-Agar and Chitosan as Precursors in the Synthesis of Functional Film for Foods: A Review

Effect of wogonin, an active ingredient of Scutellariae Radix, on fish infected with Aeromonas hydrophila

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