Anti-Inflammatory and Antipyretic Activities of β-Sitosterol

Gupta, Mradu; Nath, R; Srivastava, N.; Shanker, Karuna; Kishor, K.; Bhargava, K. P.

doi:10.1055/s-2008-1074919

Cited by 221 publications

(129 citation statements)

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“…The anti-inflammatory activity of BS inhibited the reversed passive Arthus reaction probably because of the inhibition of the mediators that give rise to the full Arthurs lesion; in this sense, other authors have provoked ovoalbumin-induced asthmatic mice, and found that BS mitigated the inflammation by eosinophil infiltration and mucus hypersecretion by goblet hyperplasia, and that various inflammatory biomarkers also decreased in the lung tissue and brochoalveolar lavage fluid (Yuk et Furthermore, our results also showed that BS diminished the edema produced by TPA, as well as the mieloperoxidase activity, results which were related to a non-specific inflammatory reaction. In this respect, studies regarding the anti-inflammatory effect of BS have been published since the early 80s, where authors showed such an effect employing carrageenan-induced edema, cotton pellet implantation and Brewer`s yeast induced pyrexia in rats (Gupta et al, 1980). From that time onward a number of anti-inflammatory, antypiretic, antinociceptive, and immunomodulating activities have also been reported (Bouic, 2002;Saeidnia et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Anti-Inflammatory Capacity of Beta-Sitosterol in Rodent Assays

Paniagua-Pérez¹,

Flores-Mondragón²,

Reyes-Legorreta³

et al. 2016

AJTCAM

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Background: Beta-sitosterol (BS) is a compound discovered to be present in numerous plants. A number of interesting biomedical properties have been attributed to BS, including immuno-modulating and anti-inflammatory activities. Therefore, the aim of this report was to evaluate its anti-inflammatory capacity by applying various rodent experimental tests. Methods. To carry out the objective of the study we applied the methods indicated here. Two of the adopted methods were based on the passive reverse Arthus reaction: the rat paw edema test and the rat pleurisy assay. We also applied two methods related with the non-specific acute inflammation: the mouse ear edema test, and the mouse mieloperoxidase activity assay. Results. The results obtained in all tests established a significant anti-inflammatory potential of BS. In the rat paw edema test we found an inhibitory effect which goes from 50-70%; in the rat pleurisy assay our findings with respect to the volume of pleural exuded showed a reduction of 46%, as well as a 20% low amount of neutrophils in comparison with the level of the control group. In the mouse ear edema test we found a mean inflammatory inhibition of 75%, and with respect to mieloproxidase activity the results showed a significant inhibition induced by the three doses of BS. Conclusions. In the present study we determined a potent anti-inflammatory capacity of BS in specific and nonspecific types of acute inflammation in rodents.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the Anti-Inflammatory Capacity of Beta-Sitosterol in Rodent Assays

Paniagua-Pérez¹,

Flores-Mondragón²,

Reyes-Legorreta³

et al. 2016

AJTCAM

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“…Beta-sitosterol possessed anti-inflammatory and antipyretic activity (Gupta et al 1980). Methanol extract of rhizome is antidiarrheal (Uddin et al 2006).…”

Section: Indigenous Use (Earlier Studies)mentioning

confidence: 99%

Indigenous Use and Ethnopharmacology of Medicinal Plants in Far-West Nepal

Kunwar

Uprety

Burlakoti

et al. 2009

Ethnobot. Res. App.

346

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Ethnopharmacological knowledge is common and import among tribal populations but much of the information is empirical at best lacking scientific validation. Despite widespread use of plant resources in traditional medicines, bioassay analysis of very few plant species have been conducted to investigate their medicinal properties, and to ascertain safety and efficacy of traditional remedies. The present study analyses indigenous uses of medicinal plants of far-west Nepal and compares with earlier ayurveda studies, phytochemical assessments and pharmacological actions. A field study was carried out in Baitadi and Darchula districts of far-west Nepal. Group discussions, informal meetings, questionnaire surveys and field observations were employed for primary data collection. Voucher specimens were collected with field notes and codes and deposited at Tribhuvan University Central Herbarium (TUCH), Kathmandu. Only 50% of species surveyed shared common uses with ayurvedic medicine. This implies that these herbal remedies are part of an independent health care system in the Nepal Himalaya, which is indigenous and influenced by ayurveda. The folk uses of some of the species were contradicting to those of ayurveda and phytochemical bioassays. A detailed phytochemical study on those species would be an important line of research. IntroductionMedicinal plants help in alleviating human suffering and are widely used for subsistence, home remedies, and trade (Kunwar et al. 2006). It is estimated that 70-80% of people worldwide rely on traditional herbal medicine to meet their primary health care needs (Farnsworth & Soejarto 1991). The ayurveda is an ancient traditional system of medicine with remedies for health and alleviation of illness. The acceptance of the ayurveda is gearing up and use of indigenous drugs of natural/plant origin is a maPublished: January 16, 2009 Ethnobotany Research & Applications 6www.ethnobotanyjournal.org/vol7/i1547-3465-07-005.pdf cuna pruriens (L.) DC. for Parkinson's disease, Commiphora as a hypolipidemic, Asclepias as cardiotonic, psoralens for vitiligo, curcumines for inflammation, baccoside for mental retention, picrosides for hepatoprotective, diosgenin for the synthesis of steroidal hormones, guggulsterons as hypolipidemic, piperidine as bioavailability enhancers, asarone as hallucinogenic, phyllanthins as anti-virals, withanolides and many other steroidal lactones and their glycosides as immunomodulators (Jain 1994, Patwardhan 2000. As an example, the sale of drugs derived from the plant Taxus The increasing use of traditional therapies demands more scientifically sound evidence for the principles behind therapies and for effectiveness of medicines (Patwardhan et al. 2005). The therapies are often criticized due to dearth of research, critical evaluation, in vivo studies and validations (Fong 2002, Houghton 1995 to support the safety of uses. At the same time, ethnopharmacological knowledge is percolating down these days among the tribal population. The present study, therefore aim...

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“…It has been demonstrated that the stigmasterol was active in reducing the edema by 41% inhibition at doses of 0.5 mg/ear. 27 Most articles on anti-inflammatory activity describe the most common type of evaluation which are the carrageenan-induced paw edema 26 and the TPA-induced ear edema. 27 However, as several authors describe in the literature, the paw edema test is not specific for anti-inflammatory drugs, as anti-cholinergic drugs also reduce the edema.…”

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confidence: 99%

Steroidal and phenolic compounds from Sidastrum paniculatum (L.) Fryxell and evaluation of cytotoxic and anti-inflammatory activities

et al. 2010

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Recebido em 28/5/09; aceito em 17/11/09; publicado na web em 2/3/10Sidastrum paniculatum (L.) Fryxell belongs to the family Malvaceae and is popularly known as "malva roxa" or "malvavisco". The phytochemical study of the hexane, CHCl 3 and EtOAc phases from the crude ethanol extract of S. paniculatum led to the isolation of six compounds: a mixture of b-sitosterol and stigmasterol, 4-methoxy-3-hydroxybenzoic acid, 4-methoxy-3-hydroxybenzaldehyde, N-trans-feruloyltyramine and kaempferol-3-O-b-D-(6''-E-p-coumaroyl) glucoside. The structural identification of the compounds was made on the basis of spectroscopic methods such as IR, 1 H and 13 C NMR with the aid of including two-dimensional techniques, besides comparison with literature data. The b-sitosterol and stigmasterol mixture showed a significant anti-inflammatory activity.

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Anti-Inflammatory and Antipyretic Activities of β-Sitosterol

Abstract: Key Word Index: P-Sitosterol; Anti-inflammatory; Antipyretic. AbstractThe anti-inflammatory and antipyre-

Cited by 221 publications

References 2 publications

Evaluation of the Anti-Inflammatory Capacity of Beta-Sitosterol in Rodent Assays

Evaluation of the Anti-Inflammatory Capacity of Beta-Sitosterol in Rodent Assays

Indigenous Use and Ethnopharmacology of Medicinal Plants in Far-West Nepal

Steroidal and phenolic compounds from Sidastrum paniculatum (L.) Fryxell and evaluation of cytotoxic and anti-inflammatory activities

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