Anti-Inflammatory and Antipyretic Activities of Azadirachta indica*

Abstract

The anti-inflammatory and antipyretic activities, as well as the acute toxicity of Azadirachta indica (Neem tree) extract were studied. It was found to have a pronounced anti-inflammatory (rat paw oedema) and a fairly good antipyretic effect (pyrogen induced hyperpyrexia in rabbits). The acute oral toxicity test in mice showed a very low range of approximately 13 g/kg body weight.

Biomonitoring the Chemopreventive Potential of the Plant Products Neem and Turmeric in 4-Nitroquinoline 1-Oxide-Induced Oral Carcinogenesis.

“…Dietary administration of turmeric was shown to be a potent inhibitor of iron-induced lipid peroxidation [36]. The hepatoprotective, anti-inflammatory, immunomodulatory, and antiulcerogenic effects of neem have been reported during xenobiotic treatment [37][38][39][40]. Of late, there has been considerable interest in the therapeutic ability of neem due to its antioxidant and antimutagenic properties.…”

The use of herbs in malaria treatment in parts of Imo State, Nigeria

“…This who used the same decoction from the leaves of guava (P. guajava), paw-paw (C. papaya) lemon grass (C. citratus) and neem tree (A. indica) on chloroquine sensitive strains of Plasmodium berghei in mice. Okpanyi & Ezeukwu (1981) furthered this finding in showing that the extract from the leaves and bark of the above plants had some antipyretic effects. One of the major approaches to the discovery as well as development of new drugs from plants is to study the plants used locally for the treatment of particular ailments.…”

Herbal Antioxidants as Rejuvenators in Alternative Medicine

“…However, the wide ranging medicinal value of the neem leaves stands out in comparison with other parts of the tree. Various studies have indicated that the neem leaves have anti-microbial (Wolinsky et al, 1996;Thakurta et al, 2007;Zhang et al, 2010), anti-inflammatory (Okpanyi and Ezeukwu, 1981;Thoh et al, 2010), analgesic (Khattak et al, 1985), antidiabetic (van der Nat et al, 1991), immunomodulatory (Ray et al, 1996), anti-oxidant (Arivazhagan et al, 2000) and anti-cancer (Miller et al, 1992;Akudugu et al, 2001) properties. Due to its numerous pharmacological activities neem leaves are used as a kaya karpam to promote longevity.…”