Biomonitoring the Chemopreventive Potential of the Plant Products Neem and Turmeric in 4-Nitroquinoline 1-Oxide-Induced Oral Carcinogenesis.

Nagini, Siddavaram; Manoharan, Shanmugam

doi:10.3164/jcbn.23.33

Cited by 16 publications

(11 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Enhanced lipid peroxidation combined with depletion of antioxidants in the liver and circulation of tumor-bearing hamsters observed in the present study is a characteristic finding in malignant transformation [18,27,28]. Administration of neem leaf extract reversed the changes induced by DMBA, thus supporting the hypothesis that plant products are effective chemopreventive agents.…”

Section: Resultssupporting

confidence: 82%

See 1 more Smart Citation

Chemoprotective Effects of Neem Leaf Extract on 7,12-Dimethylbenz(a)anthracene (DMBA)-Induced Hamster Buccal Pouch Carcinogenesis.

Balasenthil

Arivazhagan

Nagini

1999

J. Clin. Biochem. Nutr.

Self Cite

View full text Add to dashboard Cite

SummaryThe chemoprotective effects of neem (Azadirachta indica A. Juss.) on hepatic and circulatory lipid peroxidation and on antioxidant and detoxifying enzyme status during 7,12-dimethylbenz [ a ] anthracene (DMBA)-induced buccal pouch carcinogenesis was investigated in Syrian male hamsters. Enhanced lipid peroxidation in the liver and circulation of tumor-bearing animals was accompanied by a significant decrease in reduced glutathione (GSH) concentration and activities of the detoxifying enzymes glutathione peroxidase (GPx) and glutathione-Stransferase (GST). Administration of neem leaf extract significantly decreased the formation of lipid peroxides and enhanced the levels of antioxidants and detoxifying enzymes. We speculate that neem leaf extract exerts its effects by modulating lipid peroxidation and enhancing antioxidant and detoxification systems. Medicinal plants and their active principles have attracted the focus of recent attention as potential chemopreventive agents. The aqueous leaf extract of Azadirachta indica A. Juss., commonly known as neem, has been traditionally used in India in the treatment of inflammation, viral infection, hypertension, fever, skin disorders, and malignancies [1,2]. The anti-mutagenic and anti-carcinogenic properties of neem preparations have been documented [3][4][5]. In a previous report from this laboratory, we demonstrated the inhibition of 4-nitroquinoline 1-oxide (4NQ0)-induced oral carcinogenesis by neem leaf extract [6].Hamster buccal pouch carcinogenesis induced by 7,12-dimethylbenz [ a ] an-

show abstract

Section: Resultssupporting

confidence: 82%

“…Measurement of circulatory markers is non-invasive and reflects the bioavailability of metabolites after sequestration by the tumor cells [17]. Previously, we reported the importance of examining changes in the host liver and circulation in biomonitoring the chemopreventive potential of neem in 4NQ0-induced oral carcinogenesis [18].…”

Section: Discussionmentioning

confidence: 99%

Chemoprotective Effects of Neem Leaf Extract on 7,12-Dimethylbenz(a)anthracene (DMBA)-Induced Hamster Buccal Pouch Carcinogenesis.

Balasenthil

Arivazhagan

Nagini

1999

J. Clin. Biochem. Nutr.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Yadav and Rathore [62] observed inhibition of mitotic activity by neem leaf extract. Studies from this laboratory have demonstrated the chemopreventive potential of neem leaf extracts on MNNG-induced forestomach tumours and 4-nitroquinoline 1-oxide induced oral carcinogenesis [63][64][65][66][67][68]. Aqueous as well as alcoholic extracts of neem leaf effectively suppressed DMBA-induced HBP carcinogenesis by modulating the cellular redox status as well as carcinogen-metabolizing enzymes in the target organ, as well as in host liver and blood [61,[69][70][71].…”

Section: Anticancer Activitymentioning

confidence: 99%

Medicinal Properties of Neem Leaves: A Review

Rajamanickam

Nagini²

2005

CMCACA

463

265

View full text Add to dashboard Cite

Azadirachta indica, commonly known as neem, has attracted worldwide prominence in recent years, owing to its wide range of medicinal properties. Neem has been extensively used in Ayurveda, Unani and Homoeopathic medicine and has become a cynosure of modern medicine. Neem elaborates a vast array of biologically active compounds that are chemically diverse and structurally complex. More than 140 compounds have been isolated from different parts of neem. All parts of the neem tree- leaves, flowers, seeds, fruits, roots and bark have been used traditionally for the treatment of inflammation, infections, fever, skin diseases and dental disorders. The medicinal utilities have been described especially for neem leaf. Neem leaf and its constituents have been demonstrated to exhibit immunomodulatory, anti-inflammatory, antihyperglycaemic, antiulcer, antimalarial, antifungal, antibacterial, antiviral, antioxidant, antimutagenic and anticarcinogenic properties. This review summarises the wide range of pharmacological activities of neem leaf.

show abstract

“…Circulatory levels of lipid peroxidation and antioxidants are reliable indicators, because they reflect the bioavailability as well as increased utilization to counter lipid peroxidation. 10 This present study aims to evaluate the modifying effects of aqueous extract of T. arjuna bark (TaBet) on circulatory lipid peroxidation, reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) as well as vitamin E and ascorbic acid as biomarkers…”

Section: Terminalia Arjuna (Roxb) Modulates Circulatory Antioxidantsmentioning

confidence: 99%

Terminalia Arjuna (Roxb.) Modulates Circulatory Antioxidants on 7,12-dimethylbenz(a)anthracene- induced Hamster Buccal Pouch Carcinogenesis

Dhanarasu¹

2010

OMJ

View full text Add to dashboard Cite

show abstract

Biomonitoring the Chemopreventive Potential of the Plant Products Neem and Turmeric in 4-Nitroquinoline 1-Oxide-Induced Oral Carcinogenesis.

Abstract: SummaryThe

Cited by 16 publications

References 29 publications

Chemoprotective Effects of Neem Leaf Extract on 7,12-Dimethylbenz(a)anthracene (DMBA)-Induced Hamster Buccal Pouch Carcinogenesis.

Chemoprotective Effects of Neem Leaf Extract on 7,12-Dimethylbenz(a)anthracene (DMBA)-Induced Hamster Buccal Pouch Carcinogenesis.

Medicinal Properties of Neem Leaves: A Review

Terminalia Arjuna (Roxb.) Modulates Circulatory Antioxidants on 7,12-dimethylbenz(a)anthracene- induced Hamster Buccal Pouch Carcinogenesis

Contact Info

Product

Resources

About