Anti-inflammatory and Antitumor-Promoting Effects of the Triterpene Acids from the Leaves of Eriobotrya japonica

Banno, Norihiro; Akihisa, Toshihiro; Tokuda, Harukuni; Yasukawa, Ken; Taguchi, Yosuke; Akazawa, Hiroyuki; Ukiya, Motohiko; Kimura, Yumiko; Suzuki, Takashi; Nishino, Hoyoku

doi:10.1248/bpb.28.1995

Cited by 129 publications

(83 citation statements)

References 37 publications

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“…Leaves of Eriobotrya japonica (LEJ) Lindl (Rosaceae) have been used as traditional medicines for lung and stomach diseases and have been found to be effective in chronic bronchitis, inflammation, asthma, low back pain and tumor. [1][2][3]4 Studies have demonstrated that LEJ has anti-inflammatory activity in a 12-O-tetradecanoylphorbol-13-acetate induced inflammation model. These reports strongly suggest that LEJ can be used as an anti-inflammatory agent.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory and antioxidant properties of Eriobotrya japonica leaves extracts

Kammoun¹,

Yassine²,

Bezzine³

2015

Afr H. Sci.

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Background: In the present work we determined phenolic and flavonoids content of Eriobotrya japonica leaves extracts and fractions and their antioxidant and anti-inflammatory properties. Objectives: To evaluate the inhibition of inflammatory PLA2 and antioxidant effects of extracts and fractions from Eriobotrya japonica leaves Methods: Antioxidant activity was evaluated with DPPH radical scavenging assay and anti-inflammatory effect of fractions was measured by their inhibition potency on the human pro-inflammatory phospholipase A2 (group IIA). Results: The EtOH/EtOAc 2:1 extract exhibited a potent inhibition of the hG-IIA with an IC50 values of 8 µg/ml. It also shows an antioxidant activity measured on DPPH with an IC50 of 42 µg/ml. Fractionation shows that CH2Cl2/MeOH 0:1 fraction was the rich one on flavonoids compounds (4.3 mg/g dry weight) and demonstrates a high antioxidant activity with an IC50 of 12 µg/ml. The anti-inflammatory evaluation demonstrates that the same fraction was the best one to inhibit the pro-inflammatory phospholipase A2 group IIA with an IC50 of 4 µg/ml. Conclusion: Study conducted on Eriobotrya japonica shows that CH2Cl2/MeOH 0:1 fraction inhibits efficiently the hG-IIA phospholipase.which is considered as pro-inflammatory enzyme.

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Section: Introductionmentioning

confidence: 99%

Anti-inflammatory and antioxidant properties of Eriobotrya japonica leaves extracts

Kammoun¹,

Yassine²,

Bezzine³

2015

Afr H. Sci.

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“…Although fresh loquat leaves have been reported to have biological activities such as antioxidant and anti-inflammatory activities [14][15][16], there is no report on the biological activities of roasted loquat leaves (loquat tea). In the present study, we used antioxidant activity-guided fractionation to investigate the biological activities of loquat tea.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and anti-inflammatory activities of loquat (Eriobotrya japonica) tea

Zar

Sakao²,

Hashimoto

et al. 2013

FFHD

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Background: Fresh loquat leaves contain several kinds of flavonoids and have been reported to have preventive effects against some human diseases such as diabetes, coughs and ulcers,. Recently, fresh loquat leaves in Japan were processed to a beverage, called loquat tea, after the fresh leaves are roasted at 350C for 30 minutes. However, the scientific evidence supporting the functions of these processed leaves is still minimal.Objective: The aim of this study is to investigate the antioxidant and anti-inflammatory activities of roasted loquat tea extract (LTE) in vitro and in culture cells. Methods:Bioactive fractions of LTE were separated by column chromatograph. Antioxidant activities were determined by DPPH and ROS assay. Pro-inflammatory mediators cyclooxygenase-2 (COX-2) and prostaglandin E 2 (PGE 2 ) were determined by Western blot and ELISA assay, respectively. Chemical quantification and characterization were analyzed by HPLC, FR-IR, and NMR. Phenolic content was measured by Folin-Ciocalteu assay. Results:The results showed that loquat tea extract (LTE) possessed stronger DPPH scavenging activity than fresh. Cellular data revealed that LTE inhibited the production of reactive oxygen species (ROS), and further suppressed the production of COX-2 and PGE 2 in lipopolysaccharide (LPS)-activated RAW 264.7 cells. Chemical quantification and characterization data indicated that LTE contained new bioactive phenolic components that were produced from the roasting processes of fresh loquat leaves. Conclusions: Loquat tea made from roasted loquat leaves contained new bioactive phenolic compounds that contribute to its antioxidant and anti-inflammatory activities.

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“…비파엽의 성분으로는 quercetin, ursolic acid, oleanolic acid, tannin, chlorogenic acid, caffeoylquinic acid 등이 보고되어 있다 [12][13][14]. 비파엽 추출물의 활성에 대한 연구로는 향균활성, 항 산화, 아질산염 소거 및 항돌연변이 효과와 항암효과 등 이 보고되어 있으며 식품 재료로서의 연구 또한 이루어 지고 있다 [15].…”

Section: 서 론unclassified

Antioxidative Effect and Component Analysis of Eriobotrya japonica Leaf Extracts

Kim¹,

Park²,

Park³

2012

Journal of the Society of Cosmetic Scientists of Korea

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In the present study, the antioxidative properties, inhibitory activity on tyrosinase, and active components of Eriobotrya japonica (E. japonica) leaf extract were investigated. The free radical (1,1-diphenyl-2-picrylhydrazyl, DPPH) scavenging activity (FSC50) of extract/fraction of E. japonica leaf was in the order 50 % ethanol extract (22.625 µg/mL) < ethyl acetate fraction (6.75) < deglycosylated aglycone fraction (5.06). Reactive oxygen species (ROS) scavenging activities (OSC50) of fraction/extracton ROS generated in Fe 3+ -EDTA/H2O2 system using the luminol-dependent chemiluminescenceassay were investigated. OSC50 of the ethyl acetate fraction, deglycosylated aglycone fraction, and ethanol extract were 0.75, 0.79, and 1.61 µg/mL, respectively. The cellular protective effects of E. japonica leaf extract on the rose-bengal sensitized photohemolysis of human erythrocytes were investigated. The protective effects of extract/fraction of E. japonica leaf were increased in a in a concentration dependent manner (5 ∼ 50 µg/mL). Especially, τ50 of ethyl acetate fraction at concentrations of 10 µg/mL and 50 µg/mL showed the most protective effects at 390.8 min and 1471.5 min. The inhibitory effect (IC50) on tyrosinase of E. japonica 1) † 주 저자

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Anti-inflammatory and Antitumor-Promoting Effects of the Triterpene Acids from the Leaves of Eriobotrya japonica

Cited by 129 publications

References 37 publications

Anti-inflammatory and antioxidant properties of Eriobotrya japonica leaves extracts

Anti-inflammatory and antioxidant properties of Eriobotrya japonica leaves extracts

Antioxidant and anti-inflammatory activities of loquat (Eriobotrya japonica) tea

Antioxidative Effect and Component Analysis of Eriobotrya japonica Leaf Extracts

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