Anti-Inflammatory and Gastroprotective Effects of Escin

Abstract

Escin is a triterpenoid saponin extracted from the fruit of Aesculus wilsonii Rehd. and Aesculus hippocastanum (Hippocastanaceae). Clinically, it is widely used in the treatment of edema induced by either trauma or surgery, as well as treating chronic venous insufficiency. The anti-inflammatory and antiedema effects of escin have been extensively investigated. This article systematically reviews the effects of escin on inflammation and gastrointestinal diseases, including its role in inflammation, as an antioxidant, and in inhibiting gastric acid secretion and promoting gastrointestinal movement, especially, the molecular mechanism. The advantages and potential uses of escin have also been discussed.

Anti-Inflammatory Activity of Crude Extract of Aesculus Indica in Comparison with Aspirin on Carrageenan Induced Paw Edema in Rats

“…It also augments the endogenous antioxidant capacity. 1 The results of the mentioned studies are similar to our study. However, as the results of this study are based on a single-centre, more studies are required to generalize it.…”

“…Its local reactions include pain, oedema and loss of function, which may be partial or complete, while the increase in neutrophil level and fever are considered systemic responses. 1 Since ancient times, medicinal plants have been used immensely to treat many diseases. Plants possess the ability to form secondary metabolites such as flavonoids, proteins, alkaloids, phenolic substances, and steroids, making them integral in the treatment of many diseases.…”

Comparison of Semen Aesculi species from different geographical origins and horse chestnut based on metabolomics and chemometrics analysis

“…Triterpenoid saponins and flavonoids are regarded as the major constituents responsible for the pharmacological activity of the genus Aesculus 5 . Escin, a mixture of triterpenoid saponins, 5 demonstrate a wide range of biological applications and potential medicinal values, such as anti‐inflammation, 8,9 antioxidant, 10 anti‐cancer, 11 gastrointestinal protection, 12 neuroprotection 13 and so on 14 . Moreover, flavonoids are natural phytochemicals that act via antiviral, 15 antioxidant 16 and inhibitory activities 17 .…”

Sodium aescinate reduces the incidence of Prolonged postoperative ileus after open surgery of advanced gastric cancer

“…Sodium aescinate is a triterpenoid saponin sodium salt extracted from the mature fruit of Borneo after drying. Sodium aescinate α and sodium aescinate β are the main components of sodium aescinate [4].…”