Anti-inflammatory and hepatoprotective effects of exopolysaccharides isolated from Pleurotus geesteranus on alcohol-induced liver injury

Song, Xinling; Zhong-hai, Liu; Zhang, Jianjun; Yang, Qihang; Ren, Zhenzhen; Zhang, Chen; Liu, Min; Gao, Zheng; Zhao, Huajie

doi:10.1038/s41598-018-28785-0

Cited by 26 publications

(18 citation statements)

References 57 publications

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“…The secretion of TNF and IL-12 by PCPS-activated DCs could significantly be eased by an anti-Dectin-1 antibody, as well as by a Syk kinase and a Raf-1 inhibitor, suggesting that PCPS motivated Dectin-1 signaling at least partly via the Syk- and the Raf1-dependent pathways in DCs [ 85 ]. Song et al reported that anti-inflammatory and hepatoprotective effects of exopolysaccharides (EPS) extracted and purified from Pleurotus geesteranus on alcohol-induced liver injury [ 210 ]. Changes in anti-inflammatory factors are essentially consistent with the other EMFs polysaccharides mentioned above.…”

Section: Antiviral Mechanisms Of Emfs Polysaccharidesmentioning

confidence: 99%

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Classification, structure and mechanism of antiviral polysaccharides derived from edible and medicinal fungus

Guo

Chen

Gong

2021

International Journal of Biological Macromolecules

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The deficiency of chemical-synthesized antiviral drugs when applied in clinical therapy, such as drug resistance, and the lack of effective antiviral drugs to treat some newly emerging virus infections, such as COVID-19, promote the demand of novelty and safety anti-virus drug candidate from natural functional ingredient. Numerous studies have shown that some polysaccharides sourcing from edible and medicinal fungus (EMFs) exert direct or indirect anti-viral capacities. However, the internal connection of fungus type, polysaccharides structural characteristics, action mechanism was still unclear. Herein, our review focus on the two aspects, on the one hand, we discussed the type of anti-viral EMFs and the structural characteristics of polysaccharides to clarify the structure-activity relationship, on the other hand, the directly or indirectly antiviral mechanism of EMFs polysaccharides, including virus function suppression, immune-modulatory activity, anti-inflammatory activity, regulation of population balance of gut microbiota have been concluded to provide a comprehensive theory basis for better clinical utilization of EMFs polysaccharides as anti-viral agents.

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Section: Antiviral Mechanisms Of Emfs Polysaccharidesmentioning

confidence: 99%

“…Changes in anti-inflammatory factors are essentially consistent with the other EMFs polysaccharides mentioned above. [ 210 ].…”

Section: Antiviral Mechanisms Of Emfs Polysaccharidesmentioning

confidence: 99%

Classification, structure and mechanism of antiviral polysaccharides derived from edible and medicinal fungus

Guo

Chen

Gong

2021

International Journal of Biological Macromolecules

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“…The DFG was purified by DEAE‐52 cellulose column chromatography according to the method of Song et al (2018) with a slight modification. A 1 ml of the DFG rough solution obtained by previous step was diluted into 5 ml and was fractionated by the DEAE‐52 cellulose column (26 mm × 400 mm); the column was stepwise eluted with distilled water and 0.2 mol/L NaCl solution with a flow rate of 1.0 ml/min.…”

Section: Methodsmentioning

confidence: 99%

The Sirtuin‐1 relied antioxidant and antiaging activity of 5,5′‐diferulic acid glucoside esters derived from corn bran by enzymatic method

et al. 2020

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Maize is the food crop with the highest total output in the world. However, corn bran is only a by-product with low price. The 5,5′-diferulic acid glucoside esters (DFG) were obtained from corn bran using the enzymatic method. DFG showed obvious antioxidant capacity in cell, Caenorhabditis elegans (C. elegans) and in mouse. DFG decreased ROS and MDA content in 500 μM H 2 O 2 stimulated ARPE-19 cells to 48.6% and 32.2%, respectively. DFG decreased ROS content in C. elegans to 49.1% and MDA content in acute ethanol (50%, 12 ml/kg) stimulated mouse to 30.4%. DFG also increased SOD protein content significantly in cell, C. elegans and mouse to 175.5%, 120.1%, and 126.2%, respectively. DFG significantly extended the lifespan of C. elegans both under heat stress and natural situation. The median survival time was prolonged to 133.3% and 116.7%, respectively. This capacity relied on the SIR-2.1 activity. SIR-2.1 is an ortholog of human Sirtuin-1 (SIRT-1). DFG also upregulated SIRT-1 and PCG-1α expression level obviously in H 2 O 2-stimulated ARPE-19 cells (to 134.4% and 127.1%, respectively) and in acute ethanol stimulated mouse eyes (to 135.1% and 111.5%, respectively) and liver (to 123.3% and 113.6%, respectively). These results indicate that DFG has multiple bioactivities. Our research provides a new application prospect of corn bran. And to our best knowledge, this is the first time, the sirtuinsrelied lifespan extension activity of the 5,5′-diferulic acid extracted from corn bran was reported. Practical applications The traditional method for extracting diferulic acid from corn bran is to use the strong alkali. Obviously, this is not welcomed by the food industry. We employed the biological enzyme method in a relatively mild pH range during the extraction process. It is more environmentally friendly and more economical. DFG can be added as a raw material for functional foods like yogurt, fruit juice, and cereals. As well, the solid precipitate obtained after extraction can also be used as high-quality dietary fiber

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“…Magnolol Down-Regulated the Expression of iNOS, Cox-2, and CYP2E1 in Alcoholic Liver Damage iNOS and Cox-2 are usually activated in the process of oxidative stress and inflammation, which result in tissue damage (Song et al, 2018). CYP2E1 is also a key enzyme in regulating alcoholic liver damage.…”

Section: Magnolol Increased the Antioxidant Enzymes Of Sod And Gsh-pxmentioning

confidence: 99%

Magnolol Prevents Acute Alcoholic Liver Damage by Activating PI3K/Nrf2/PPARγ and Inhibiting NLRP3 Signaling Pathway

Liu

Wang

et al. 2019

Front. Pharmacol.

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Alcoholic liver damage (ALD) is a toxic liver damage caused by excessive drinking. Oxidative stress is one of the most crucial pathogenic factors leading to ALD. Magnolol is one of the main active constituents of traditional Chinese medicine Magnolia officinalis, which has been reported to possess many pharmacological effects including antiinflammatory, anti-oxidant, and anti-tumor. However, the effects of magnolol on ALD remain unclear. In this study, we firstly evaluated the protective effects of magnolol on ALD, and then tried to clarify the mechanism underlying the pharmacological activities. AST, ALT, GSH-Px, and SOD were detected by respective kits. Histopathological changes of liver tissue were analyzed by H&E staining. The activities of PI3K, Nrf2, and NLRP3 signaling pathways activation were detected by western blotting analysis. It was showed that alcohol-induced ALT and AST levels were significantly reduced by magnolol, but the antioxidant enzymes of GSH-Px and SOD levels were significantly increased. Magnolol attenuated alcohol-induced pathologic damage such as decreasing hepatic cord swelling, hepatocyte necrosis, and inflammatory cell infiltration. Furthermore, it was found that magnolol inhibited oxidative stress through up-regulating the activities of HO-1, Nrf2, and PPARg and the phosphorylation of PI3K and AKT. And magnolol also decreased inflammatory response by inhibiting the activation of NLRP3inflammasome, caspase-1, and caspase-3 signaling pathway. Above results showed that magnolol could prevent alcoholic liver damage, and the underlying mechanism was through activating PI3K/Nrf2/ PPARg signaling pathways as well as inhibiting NLRP3 inflammasome, which also suggested magnolol might be used as a potential drug for ALD.

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Anti-inflammatory and hepatoprotective effects of exopolysaccharides isolated from Pleurotus geesteranus on alcohol-induced liver injury

Cited by 26 publications

References 57 publications

Classification, structure and mechanism of antiviral polysaccharides derived from edible and medicinal fungus

Classification, structure and mechanism of antiviral polysaccharides derived from edible and medicinal fungus

The Sirtuin‐1 relied antioxidant and antiaging activity of 5,5′‐diferulic acid glucoside esters derived from corn bran by enzymatic method

Magnolol Prevents Acute Alcoholic Liver Damage by Activating PI3K/Nrf2/PPARγ and Inhibiting NLRP3 Signaling Pathway

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