Anti-inflammatory and hypolipemic effects in vitro of simvastatin comparing to epicatechin in patients with type-2 hypercholesterolemia

Franiak-Pietryga, Ida; Koter−Michalak, Maria; Broncel, Marlena; Duchnowicz, Piotr; Chojnowska-Jezierska, J

doi:10.1016/j.fct.2008.11.027

Cited by 17 publications

(12 citation statements)

References 28 publications

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“…nonconventional treatments for hypercholesterolemia, such as novel drugs based on a natural product, tea catechins (mainly gallate ester derivatives) have been tested successfully both in vitro and in vivo as cholesterol-lowering agents (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25). Globally, these fi ndings indicate that catechins exert concerted, multiple-level action involving the upregulation of the LDL receptor ( 15,24 ), the reduction of cholesterol absorption ( 16,26,27 ), and the modulation of both synthetic ( 15,28,29 ) and metabolic pathways ( 24 ).…”

mentioning

confidence: 96%

Epigallocatechin-3-gallate potently inhibits the in vitro activity of hydroxy-3-methyl-glutaryl-CoA reductase

Cuccioloni¹,

Mozzicafreddo²,

Spina

et al. 2011

Journal of Lipid Research

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mentioning

confidence: 96%

Epigallocatechin-3-gallate potently inhibits the in vitro activity of hydroxy-3-methyl-glutaryl-CoA reductase

Cuccioloni¹,

Mozzicafreddo²,

Spina

et al. 2011

Journal of Lipid Research

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“…This suggests that ApoE lipoproteins participate in some way in the processing of APP, perhaps by modulating APP secretases, and may also play a role in the assembly of the neuronal cytoskeleton. High cholesterol levels during mid-life increase the risk of Alzheimer's disease and lipid-lowering therapies including the consumption of wine-derived phenolic compounds can lower this risk which may accordingly lower the risk of developing Alzheimer's disease [140][141][142].…”

Section: Amyloid-β and Apoe-epsilon 4 Allelementioning

confidence: 99%

Wine consumption, cognitive function and dementias – A relationship?

Stockley

2016

NUA

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Abstract. Healthy cognitive function is essential for quality of life, wellbeing and independent living, and is negatively associated with dementias. A series of longitudinal and neuro-imaging studies in the elderly have shown that light to moderate wine consumption is neuro-protective although heavy or abusive alcohol consumption is neuro-toxic. A J-shaped relationship between alcohol consumption, cognitive dysfunction and risk of dementias is also observed for younger and middle aged consumers. There is also no data to suggest that long-term light to moderate alcohol consumption exacerbates age-related cognitive decline and impairment. An optimal amount of wine for neuro-protection appears to be up to 30 g alcohol daily.There are multiple plausible biological mechanisms in various animal models, in vitro and in vivo for wine-derived phenolic compounds which go beyond their antioxidant activity and attenuation of oxidative stress.

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“…Anthraquinones such as rhein, chrysophanol, emodin and physcion reported to exhibit antioxidant and hypolipidemic activities (Xiao-Yan et al 2009;Sheeba et al 2010;Woojung et al 2012;Shu-Chun & Jing-Gung 2012;Brijesh et al 2014;Yan-Xi et al 2015). Flavonoids such as kaempferol, quercetin, myricetin, rutin, catechin, epicatechin, procyanidin B2 and epiafzelechin have been reported to exert antioxidant and hypolipidemic effects (Angela et al 2009;Franiak-Pietryga et al 2009;Chia et al 2011;Shamala et al 2014). It is well established that dietary phytosterol such as b-sitosterol lowers plasma cholesterol concentrations by inhibiting intestinal cholesterol absorption (Chan et al 2006).…”

Section: Discussionmentioning

confidence: 99%

Hypolipidemic and antioxidant effects of ethanol extract ofCassia fistulafruit in hyperlipidemic mice

Abid

Mahmood

Kumar

2016

Pharmaceutical Biology

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Context: The plant Cassia fistula L. (Caesalpiniaceae) fruit was widely used by traditional practitioners to treat cardiovascular diseases (CVDs) in India. Hyperlipidemia is a lipid metabolism disorder and the major risk factor for the development of CVDs. Although most of the current hypolipidemic drugs are expensive and have potential side effects, the research focusing on natural alternative medicines is relevant. Objective: To investigate the hypolipidemic and antioxidant effects of ethanol extract of C. fistula fruit (CFE) in high-fat diet (HFD) induced hyperlipidemia in mice. Materials and methods: Oral administration of CFE at 100, 300 and 500 mg/kg body weight on HFD induced hyperlipidemia mice for 30 days. The standard drug atorvastatin (20 mg/kg) was used to compare the efficacy of CFE. Hypolipidemic effect was evidenced by the measurement of serum lipid profile and further confirmed by Oil Red O staining of adipose tissue. The hepatic and cardiac melondialdehyde (MDA) level and antioxidant enzyme activities including superoxide dismutase, catalase and glutathione peroxidase were determined. Results: Treatment with CFE at different doses has significantly restored the levels of serum lipid, MDA and enzymes activities in the liver and heart of hyperlipidemia mice. Oil Red O staining of visceral adipose tissue has shown marked reduction of lipid accumulation in adipocytes; whereas, administration of CFE at 500 mg/kg showed remarkable (p < 0.001) hypolipidemic and antioxidant effects in HFD fed mice. Conclusion: C. fistula fruit demonstrated hypolipidemic and antioxidant properties in vivo and the results corroborate the use of this plant in traditional medicine for cardiac ailments. ARTICLE HISTORY

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Anti-inflammatory and hypolipemic effects in vitro of simvastatin comparing to epicatechin in patients with type-2 hypercholesterolemia

Cited by 17 publications

References 28 publications

Epigallocatechin-3-gallate potently inhibits the in vitro activity of hydroxy-3-methyl-glutaryl-CoA reductase

Epigallocatechin-3-gallate potently inhibits the in vitro activity of hydroxy-3-methyl-glutaryl-CoA reductase

Wine consumption, cognitive function and dementias – A relationship?

Hypolipidemic and antioxidant effects of ethanol extract ofCassia fistulafruit in hyperlipidemic mice

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