Anti-inflammatory and in vitro bone formation effects of Garcinia mangostana L. and propolis extracts

Lim, Yun Kyong; Yoo, So Young; Jang, Young Yoon; Lee, Byoung Cheon; Lee, Dong Hoon; Kook, Joong-Ki

doi:10.1007/s10068-019-00697-3

Cited by 23 publications

(25 citation statements)

References 30 publications

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“…MC3T3-E1 murine osteoblast-like cells cultured on propolis loaded titanium oxide nanotubes showed increased expression of alkaline phosphatase (ALP) and osteoblast differentiation [41]. Propolis increased mineralisation and ALP activity in human osteoblast-like MG-63 cell line [42]. Besides, propolis promoted osteoblast differentiation by increasing expression of runt-related transcription factor 2 (RUNX2), osterix (OSX), osteocalcin, and type 1 collagen alpha [42].…”

Section: Discussionmentioning

confidence: 99%

“…Propolis increased mineralisation and ALP activity in human osteoblast-like MG-63 cell line [42]. Besides, propolis promoted osteoblast differentiation by increasing expression of runt-related transcription factor 2 (RUNX2), osterix (OSX), osteocalcin, and type 1 collagen alpha [42]. The dual effects of propolis on bone formation and resorption highlight its potential in preventing osteoporosis.…”

Section: Discussionmentioning

confidence: 99%

“…For osteoblastogenesis studies, the cell models used were MC3T3-E1 and MG-63 cell lines. MC3T3-E1 pre-osteoblast cell line was unstimulated and cultured on 60% propolis-loaded plates [41], while MG-63 human osteoblast cell line was stimulated by ascorbic acid and β-glycerophosphate, and cultured with 0.017-0.034 mg/mL propolis [42]. The treatment period for osteoclast differentiation was 1-7 days, and for osteoblast differentiation was 1-14 days.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Overall, 2 studies showed that propolis suppressed osteoclastogenesis [39,40], while 2 studies showed that propolis promoted osteoblastogenesis [41,42]. In the animal experiments, propolis inhibited bone loss due to periodontitis in 2 studies [48,49], bone loss due to periodontitis/STZ-induced diabetes in 1 study [56], bone loss due to OTM in 3 studies [50][51][52] and bone loss due to dental implantitis in 1 study [41].…”

Section: Study Characteristicsmentioning

confidence: 99%

“…They also secrete OPG, a RANKL decoy receptor that prevents the binding of RANKL to RANK, thereby halting RANKL signalling and osteoclastogenesis [92]. Propolis was shown to stimulate the proliferation, differentiation and maturation of osteoblasts [42]. Among the many osteoblast markers, OPG expression was also upregulated by propolis, indicating that it could affect RANKL/OPG dynamic or crosstalk between osteoblasts and osteoclasts, thereby suppressing osteoclastogenesis.…”

Section: Possible Molecular Mechanisms Of Propolis In Preserving Skeletal Healthmentioning

confidence: 99%

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Application of Propolis in Protecting Skeletal and Periodontal Health—A Systematic Review

Ekeuku

Chin

2021

Molecules

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Chronic inflammation and oxidative stress are two major mechanisms leading to the imbalance between bone resorption and bone formation rate, and subsequently, bone loss. Thus, functional foods and dietary compounds with antioxidant and anti-inflammatory could protect skeletal health. This review aims to examine the current evidence on the skeletal protective effects of propolis, a resin produced by bees, known to possess antioxidant and anti-inflammatory activities. A literature search was performed using Pubmed, Scopus, and Web of Science to identify studies on the effects of propolis on bone health. The search string used was (i) propolis AND (ii) (bone OR osteoporosis OR osteoblasts OR osteoclasts OR osteocytes). Eighteen studies were included in the current review. The available experimental studies demonstrated that propolis could prevent bone loss due to periodontitis, dental implantitis, and diabetes in animals. Combined with synthetic and natural grafts, it could also promote fracture healing. Propolis protects bone health by inhibiting osteoclastogenesis and promoting osteoblastogenesis, partly through its antioxidant and anti-inflammatory actions. Despite the promising preclinical results, the skeletal protective effects of propolis are yet to be proven in human studies. This research gap should be bridged before nutraceuticals based on propolis with specific health claims can be developed.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%