Anti-inflammatory and Neuroprotective Effects of Transcranial Ultrasound Stimulation on Parkinson's Disease

Song, Wen-Shin; Sung, Chen-Yü; Ke, Chia-Hua; Yang, Feng-Yi

doi:10.1016/j.ultrasmedbio.2021.10.001

Cited by 18 publications

(20 citation statements)

References 40 publications

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“…Additionally, it helps to maintain normal levels of neurotrophic factors, dopamine transporters, and tight junction proteins in the blood-brain barrier in PD induced by 6-OHDA ( 125 ). Moreover, ultrasound stimulation also exhibits the potential to alter cortical excitability.…”

Section: Ultrasonic Stimulation In Central Nervous System Diseasementioning

confidence: 99%

Transcranial low-intensity ultrasound stimulation for treating central nervous system disorders: A promising therapeutic application

Ye²,

Liang³

et al. 2023

Front. Neurol.

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Transcranial ultrasound stimulation is a neurostimulation technique that has gradually attracted the attention of researchers, especially as a potential therapy for neurological disorders, because of its high spatial resolution, its good penetration depth, and its non-invasiveness. Ultrasound can be categorized as high-intensity and low-intensity based on the intensity of its acoustic wave. High-intensity ultrasound can be used for thermal ablation by taking advantage of its high-energy characteristics. Low-intensity ultrasound, which produces low energy, can be used as a means to regulate the nervous system. The present review describes the current status of research on low-intensity transcranial ultrasound stimulation (LITUS) in the treatment of neurological disorders, such as epilepsy, essential tremor, depression, Parkinson's disease (PD), and Alzheimer's disease (AD). This review summarizes preclinical and clinical studies using LITUS to treat the aforementioned neurological disorders and discusses their underlying mechanisms.

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Section: Ultrasonic Stimulation In Central Nervous System Diseasementioning

confidence: 99%

Transcranial low-intensity ultrasound stimulation for treating central nervous system disorders: A promising therapeutic application

Ye²,

Liang³

et al. 2023

Front. Neurol.

View full text Add to dashboard Cite

show abstract

“…Similarly, another research on Parkinson's disease rat model found that the low-intensity pulsed ultrasound treatment significantly inhibited 6-OHDA-induced glial activation and the phosphorylation of nuclear factor-κB p65 in the substantia nigra pars compacta. Further evaluation revealed that low-intensity pulsed ultrasound effectively preserved the levels of neurotrophic factors, dopamine transporter, and tight junction proteins in the blood-brain barrier (Song et al, 2021). Furthermore, (Zhou et al, 2021) revealed that TUS reduced the chronic inflammatory response in microglia and astrocyte activation, whereas Pang et al (2021) found that TUS could attenuate the level of TNF-α .…”

Section: Reduced Inflammatory Response and Apoptosismentioning

confidence: 99%

The Updated Role of Transcranial Ultrasound Neuromodulation in Ischemic Stroke: From Clinical and Basic Research

Zhu¹,

Meng²,

Jiang³

et al. 2022

Front. Cell. Neurosci.

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Ischemic stroke is a common cause of death and disability worldwide, which leads to serious neurological and physical dysfunction and results in heavy economic and social burdens. For now, timely and effective dissolution of thrombus, and ultimately improvement in the recovery of neurological functions, is the treatment strategy focus. Recently, many studies have reported that transcranial ultrasound stimulation (TUS), as a non-invasive method, can dissolve thrombus, improve cerebral blood circulation, and exert a neuroprotective effect post-stroke. TUS can promote functional recovery and improve rehabilitation efficacy among patients with ischemic stroke. This mini-review summarizes the potential mechanism and limitation of TUS in stroke aims to provide a new strategy for the future treatment of patients with ischemic stroke.

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“…Former studies have demonstrated that LIPUS is responsible for accelerating bone reparations through both upregulating osteogenic-specific genes and downregulating osteoclast differentiation (Costa et al, 2018;Meng et al, 2018). LIPUS also effectively provides the mechanical force beneficial to soft tissue regeneration (Lai et al, 2021), regulating inflammation and neuromodulation (Xu et al, 2021;Song et al, 2022). Studies have shown that LIPUS has several positive effects on dentofacial remodeling, especially in root and alveolar bone resorption after orthodontic treatment.…”

Section: Introductionmentioning

confidence: 99%

LIPUS as a potential strategy for periodontitis treatment: A review of the mechanisms

Aimaijiang

Liu²,

Zhang³

et al. 2023

Front. Bioeng. Biotechnol.

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Periodontitis is a chronic inflammatory condition triggered by oral bacteria. A sustained inflammatory state in periodontitis could eventually destroy the alveolar bone. The key objective of periodontal therapy is to terminate the inflammatory process and reconstruct the periodontal tissues. The traditional Guided tissue regeneration (GTR) procedure has unstable results due to multiple factors such as the inflammatory environment, the immune response caused by the implant, and the operator’s technique. Low-intensity pulsed ultrasound (LIPUS), as acoustic energy, transmits the mechanical signals to the target tissue to provide non-invasive physical stimulation. LIPUS has positive effects in promoting bone regeneration, soft-tissue regeneration, inflammation inhibition, and neuromodulation. LIPUS can maintain and regenerate alveolar bone during an inflammatory state by suppressing the expression of inflammatory factors. LIPUS also affects the cellular behavior of periodontal ligament cells (PDLCs), thereby protecting the regenerative potential of bone tissue in an inflammatory state. However, the underlying mechanisms of the LIPUS therapy are still yet to be summarized. The goal of this review is to outline the potential cellular and molecular mechanisms of periodontitis-related LIPUS therapy, as well as to explain how LIPUS manages to transmit mechanical stimulation into the signaling pathway to achieve inflammatory control and periodontal bone regeneration.

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Anti-inflammatory and Neuroprotective Effects of Transcranial Ultrasound Stimulation on Parkinson's Disease

Cited by 18 publications

References 40 publications

Transcranial low-intensity ultrasound stimulation for treating central nervous system disorders: A promising therapeutic application

Transcranial low-intensity ultrasound stimulation for treating central nervous system disorders: A promising therapeutic application

The Updated Role of Transcranial Ultrasound Neuromodulation in Ischemic Stroke: From Clinical and Basic Research

LIPUS as a potential strategy for periodontitis treatment: A review of the mechanisms

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