Anti-inflammatory and Potential Cancer Chemopreventive Constituents of the Fruits of Morinda citrifolia (Noni)

Abstract

A new anthraquinone, 1,5,15-tri-O-methylmorindol (1), and two new saccharide fatty acid esters, 2-O-(beta-D-glucopyranosyl)-1-O-hexanoyl-beta-D-gluropyranose (4) and 2-O-(beta-D-glucopyranosyl)-1-O-octanoyl-beta-D-gluropyranose (5), have been isolated from a methanol extract of the fruits of Morinda citrifolia (noni) along with 10 known compounds, namely, two anthraquinones (2, 3), six saccharide fatty acid esters (6-11), an iridoid glycoside (12), and a flavanol glycoside (13). Upon evaluation of six compounds (5-7, 9, 10, and 13) for inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation (1 microg/ear) in mice, four saccharide fatty acid esters, 5-7 and 9, exhibited potent anti-inflammatory activity, with ID50 values of 0.46-0.79 mg per ear. In addition, when compounds 1-13 were evaluated against the Epstein-Barr virus early antigen (EBV-EA) activation induced by TPA, all of the compounds exhibited moderate inhibitory effects (IC50 values of 386-578 mol ratio/32 pmol TPA).

Induction of Mitochondrial-Mediated Apoptosis by Morinda Citrifolia (Noni) in Human Cervical Cancer Cells

“…A number of major chemical compounds have been identified in the leaves, roots, and fruits of Noni plant (Pawlus et al, 2005;Akihisa et al, 2007;Alitheen et al,a first-line chemotherapeutic agent in the treatment of epithelial malignancies, including cancer of cervix, lung, ovarian, testicular, and others. It induces tumor killing by interacting with the DNA and activating mitogen-activated protein kinase (MAPK) signaling pathway, which controls a wide spectrum of cellular processes including growth, differentiation, and apoptosis (HernandezFlores et al, 2011).…”

The fruit juice of Morinda citrifolia (noni) downregulates HIF-1α protein expression through inhibition of PKB, ERK-1/2, JNK-1 and S6 in manganese-stimulated A549 human lung cancer cells

“…Evidence suggests that products derived from the fruit of noni may have a wide range of potentially beneficial effects. For example, it is shown that noni fruit juice (NFJ) has anti-inflammatory and anticancerous activities (3,4). There is further evidence to demonstrate that NFJ inhibits angiogenic initiation and disrupts newly established human vascular networks (5), indicating its antiangiogenic activity.…”

Efecto Analgésico Postexodoncia Simple del Extracto de Morinda citrifolia (Noni): Ensayo Clínico Aleatorizado de Grupos en Paralelo

“…Teniendo en consideración que, posterior a todo procedimiento quirúrgico bucal aparece un episodio doloroso, existe plena justificación para la utilización de medicamentos que controlan y reducen la duración y grado de dolor posoperatorio (Becker;Jung et al;Romera et al, 2000). La evidencia de que el fruto de Noni presenta efecto analgésico proviene de experimentos en animales, realizados por Younos et al (1990), Punjanon & Nandhasri (2005), Akihisa et al (2007), Deng et al (2007) y Dussossoy et al (2011). Según recientes investigaciones, la inhibición de las vías metabólicas de ciclooxigenasa y lipooxigenasa pueden ser las responsables de este efecto (Wang et al;Akihisa et al;Palu et al, 2004Palu et al, , 2012.…”

“…La evidencia de que el fruto de Noni presenta efecto analgésico proviene de experimentos en animales, realizados por Younos et al (1990), Punjanon & Nandhasri (2005), Akihisa et al (2007), Deng et al (2007) y Dussossoy et al (2011). Según recientes investigaciones, la inhibición de las vías metabólicas de ciclooxigenasa y lipooxigenasa pueden ser las responsables de este efecto (Wang et al;Akihisa et al;Palu et al, 2004Palu et al, , 2012. Además, Younos et al, concluyeron que el fruto de Morinda citrifolia podría tener un efecto analgésico central, debido a que naloxona inhibió parcialmente su efecto.…”