Anti-inflammatory and proresolution activities of bergapten isolated from the roots of Ficus hirta in an in vivo zebrafish model

Yang, Yi Yuan; Zheng, Kangdi; Mei, Wenjie; Wang, Yandong; Yu, Chuqin; Yu, Bingkun; Deng, Shanbin; Hu, Jinhua

doi:10.1016/j.bbrc.2018.01.071

Cited by 56 publications

(32 citation statements)

References 18 publications

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“…In the current study, the various solvent extracts of HFF were taken for analysis, where AE showed the higher antioxidant activity in DPPH radical-scavenging assay, and EAE exhibited the stronger antioxidant activities in ABTS radical-scavenging and the FRAP assay. Current findings indicated that a significant correlation of antioxidant activity with TPC and TFC in HFF extracts occurred, which helps us explain that HFF has abundant promising natural antioxidants that retard cell aging and inflammations [2,3,14]. As shown in Table 5, five flavonoid constituents, namely pinocembrin-7-O-β-D-glucoside, naringenin-7-O-β-D-glucoside, eriodictyol-7-O-β-D-glucoside, luteolin, and apigenin, were all detected in EAE, AE, and ME.…”

Section: In Vitro Antioxidant Activities Of Hff Extractsmentioning

confidence: 63%

“…Three phenolics, namely, luteolin, apigenin, and umbelliferone, were putatively identified by comparison of extracted positive or negative ions with literature data, for which those were the main constituents previously reported [2,3]. Five flavonoid constituents (13)(14)(15)(16)(17) were all detected in EAE, AE, and ME of HFF. Furthermore, pinocembrin-7-O-β-D-glucoside (13), the main antifungal flavonoid, was also detected in CE of HFF.…”

Section: Hplc-qtof-ms Analysis Of Hff Extractsmentioning

confidence: 85%

“…The in vitro antifungal activity using six different HFFE and their in vivo efficacy to control postharvest blue mold of citrus A B Recently, the screening and isolation of botanical fungicides against citrus postharvest fungal diseases and the inhibitory effects have gained much attention [31][32][33][34][35][36]. HFF was considered to be a very promising source of health promotion being used and witnessed by the Hakka people in southern China as a folk medicine for the treatment of invigorating spleen, supplementing Qi, eliminating dampness, promoting lactation, and lessen the inflammations [2,5,14,15]. Only a few studies have focused on the antifungal activity of HFF against plant fungi.…”

Section: In Vivo Antifungal Activity Of Hff Extracts On Blue Mold Devmentioning

confidence: 99%

“…[12]. Several studies also claimed an anti-inflammatory activity of the root extracts of F. hirta Vahl., and phenylpropanoids, bergapten, lupeol palmitate, and azelaic acid were responsible for the anti-inflammatory activity [4,14,15]. However, as far as current literature survey is concerned, there are no scientific studies describing the amount of total phenolic and flavonoid contents correlated with antioxidant and antifungal activities.…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant, Antifungal Activities of Ethnobotanical Ficus hirta Vahl. and Analysis of Main Constituents by HPLC-MS

et al. 2020

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The medicinal and edible plant, Ficus hirta Vahl. (also called hairy fig), is used for the treatment of constipation, inflammation, postpartum hypogalactia, tumors, and cancer. There is an urgent need for scientific evaluation to verify the pharmacological properties of F. hirta. Therefore, in vitro assays evaluated the antioxidant and antifungal activities of various solvent extracts of hairy fig fruits (HFF). HFF extracts had abundant antioxidant components for a significant amount of total phenolic (TPC) and flavonoid contents (TFC) (TPC from 17.75 ± 0.52 to 85.25 ± 1.72 mg gallic acid/g dw and TFC from 15.80 ± 0.59 to 144.22 ± 8.46 mg rutin/g dw, respectively). The ethyl acetate extract (EAE) and acetone extract (AE) of HFF demonstrated potent antioxidant activities against 1,1-diphenyl-2-picrylhydrazyl (DPPH) (IC50 values of 2.52 and 2.02 mg/mL, respectively) and ABTS radicals (IC50 values of 3.06 and 9.26 mg/mL, respectively). Moreover, the AE with a high TFC showed a prominent in vitro and in vivo antifungal activity against Penicillium italicum, causing citrus blue mold. Eighteen metabolites were identified or putatively identified from six HFF extracts. Current findings indicated that HFF extracts had significant antioxidant and antifungal activities and could potentially be used as an alternative agent for the preservation of agricultural products.

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Section: In Vitro Antioxidant Activities Of Hff Extractsmentioning

confidence: 63%

Section: Hplc-qtof-ms Analysis Of Hff Extractsmentioning

confidence: 85%

Section: In Vivo Antifungal Activity Of Hff Extracts On Blue Mold Devmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antioxidant, Antifungal Activities of Ethnobotanical Ficus hirta Vahl. and Analysis of Main Constituents by HPLC-MS

et al. 2020

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“…Recent studies have reported that bergapten possesses various biological activities, including inhibition of ROS/NO generation to exhibit dual anti‐inflammatory and pro‐resolution activity, blockage of ABC transporter to promote chemosensitization of drug‐resistant cancer cells, regulation of phosphatidylinositide 3‐kinase (PI3K)/AKT, c‐Jun N‐terminal kinase (JNK), and nuclear factor kappa‐light‐chain‐enhancer of activated B cells (NF‐κB) signaling to inhibit diabetes‐related osteoporosis, and upregulation of PTEN to trigger autophagy . These findings indicate that bergapten is a potential therapeutic phytochemical that can not only potentially ameliorate inflammatory disorders but can also suppress the different types of carcinomas.…”

Section: Discussionmentioning

confidence: 99%

Bergapten induces G1 arrest and pro‐apoptotic cascade in colorectal cancer cells associating with p53/p21/PTEN axis

Lin

et al. 2018

Environmental Toxicology

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Bergapten is a natural compound and has potent anticancer activities. In this study, we explored the cytotoxicity of bergapten on colorectal cancer (CRC) cell DLD-1 and LoVo and its underlying mechanisms. We observed that bergapten (30 and 50 μM) decreased the viability of the CRC cells and induced the G0/G1 and sub-G1 phase arrest. Furthermore, immunoblotting results indicated that bergapten increased p53, phospho-p53(Ser-46), p21, PUMA, Bax, PTEN, and the caspase-9 and caspase-3 cleavage, but decreased cyclin E, CDK2, and phosphor-AKT(Ser-473) in the CRC cells. Inhibition of p53 by pifithrin-α reversed the bergapten-induced p53-mediated apoptotic cascade and restored the survival signaling and cell viability. Collectively, our findings reveal that bergapten decrease the cell viability and induce cell cycle arrest in the CRC cells, which may be attributed to p53-mediated apoptotic cascade, upregulation of p21 and PTEN, and inhibition of AKT. K E Y W O R D S apoptosis, colorectal cancer cells, Berga, PTEN, p21, p53

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Bergapten alleviates osteoarthritis by regulating the ANP32A/ATM signaling pathway

Zeng

et al. 2019

FEBS Open Bio

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Osteoarthritis ( OA ) is a chronic degenerative disease that commonly affects the elderly. Current drug therapies for treating OA may cause adverse side effects, and so there remains a need to develop alternative treatments. Bergapten (BG) is a coumarin phytohormone that is widely found in fruits and has antioxidative and anti‐inflammatory effects. Here, we tested the hypothesis that BG may restrict the progression of OA by examining its effect on OA chondrocytes. We observed that BG significantly ameliorated interleukin (IL)‐1β‐induced expression of inflammatory cytokines and mediators, including interleukin 1 ( Il‐1 ), interleukin 6 ( Il‐6 ), tumor necrosis factor α ( Tnf‐α ), cyclooxygenase 2 ( Cox‐2 ) and matrix metalloproteinase 13 ( Mmp‐13 ), maintained chondrocyte phenotype, and promoted the secretion of cartilage‐specific extracellular matrix. We provide evidence that BG exerts its anti‐inflammatory effect by activating the ANP 32A/ ATM signaling pathway, which was recently verified to be associated with OA . In conclusion, these findings indicate that BG may be a potential candidate for treatment of OA .

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Anti-inflammatory and proresolution activities of bergapten isolated from the roots of Ficus hirta in an in vivo zebrafish model

Cited by 56 publications

References 18 publications

Antioxidant, Antifungal Activities of Ethnobotanical Ficus hirta Vahl. and Analysis of Main Constituents by HPLC-MS

Antioxidant, Antifungal Activities of Ethnobotanical Ficus hirta Vahl. and Analysis of Main Constituents by HPLC-MS

Bergapten induces G1 arrest and pro‐apoptotic cascade in colorectal cancer cells associating with p53/p21/PTEN axis

Bergapten alleviates osteoarthritis by regulating the ANP32A/ATM signaling pathway

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