Anti-inflammatory and redox-protective activities of citronellal

Abstract

The anti-infl ammatory and redox protective effects of the citronellal (CT) were evaluated using in vivo and in vitro tests. Intraperitoneal (i.p.) administration of CT (50, 100, and 200 mg/kg) inhibited (p < 0.05) the carrageenan-induced leukocyte migration to the peritoneal cavity. Additionally, the carrageenan-and arachidonic acid-induced rat hind paw edema was signifi cantly inhibited (p < 0.05) by i.p. administration of 100 and 200 mg/kg of the compound. When the redox activity was evaluated, CT (200 mg/kg) signifi cantly reduced hepatic lipoperoxidation (p < 0.001), as well as oxidation of plasmatic (p < 0.05) and hepatic (p < 0.01) proteins. The results of the present study support the hypothesis that CT possesses anti-infl ammatory and redox protective activities. It is suggested that its effects are associated with the inhibition of the enzymes in the arachidonic acid pathway, which prevent cell migration by inhibiting leukotriene production, edema formation and the increase of reactive oxygen species in tissues. Therefore, CT is of potential benefi t to manage infl ammatory disorders and correlated damages caused by oxidant agents.

Citronellol, a monoterpene alcohol with promising pharmacological activities - A systematic review

“…Previous studies have already demonstrated the benefits of monoterpenes in the treatment of various signs and symptoms, from those of acute manifestations, to those of chronic manifestation, pointing to this class of natural products as an alternative for the development of new drugs (Guimarães et al, 2014(Guimarães et al, , 2013Melo et al, 2011;Seol et al, 2016).…”

Relaxant effect of carvacrol, citronellal and p-cymene, monoterpenes present in Thymus and Cymbopogon species, in guinea-pig trachea: A comparative study

“…Besides the antimicrobial activity some monoterpenes, such as citronellal, has anti-inflammatory (Melo et al, 2011b), antinoceptive Quintans-Junior et al, 2010), larvicidal (Barros et al, 2009) and anticancer activities (Osato, 1965;Osato et al, 1961;Osato et al, 1954), while p-cymene modulates cytokine production (Zhong et al, 2012) has anti-inflammatory (Xie et al, 2012) and antinocceptive activity (Bonjardim et al, 2012). Now, we demonstrate, through this work, that citronellal, p-cymene and carvacrol have relaxing effect on guinea-pig trachea and carvacrol has greater efficacy and potency among the three monoterpenes tested.…”

Chemical Characterization and Biological Potential of the Essential Oil of Eucalyptus globulus Labill

“…Furthermore, it is also one of the compounds responsible for the aroma of Cymbopogon, a plant known for its ability to repel insects. Citronellal also displays larvicidal, anti-inflammatory, antinociceptive, antioxidant [18,19], antimicrobial [20], and bronchodilator effects [4].…”