Relaxant effect of carvacrol, citronellal and p-cymene, monoterpenes present in Thymus and Cymbopogon species, in guinea-pig trachea: A comparative study

Silva, Yonara M. S.; Silva, Morganna T. A.; Sampaio, Pedrita Alves; Quintans, Jullyana S. S.; Quintans‐Júnior, Lucindo J.; Ribeiro, Luciano Augusto de Araújo

doi:10.5897/jmpr2013.5138

J. Med. Plants Res.

2014

DOI: 10.5897/jmpr2013.5138

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Relaxant effect of carvacrol, citronellal and p-cymene, monoterpenes present in Thymus and Cymbopogon species, in guinea-pig trachea: A comparative study

Yonara M. S. Silva¹,

Morganna T. A. Silva²,

Pedrita Alves Sampaio³

et al.

Abstract: Respiratory diseases are responsible for significant morbidity and mortality in worldwide. One of most important respiratory disease is asthma, which the current treatment is based on use of β 2 -agonists combined to inhaled corticosteroids. However, in recent years, many in vitro studies have attempted to validate the use of aromatic medicinal plants and its chemical compounds, such as monoterpenes, as potential therapeutically alternatives. In this work it was demonstrated that three different monoterpenes (… Show more

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Cited by 9 publications

References 75 publications

(68 reference statements)

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Experimental and clinical evidence on the effect of carvacrol on respiratory, allergic, and immunologic disorders: A comprehensive review

2022

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Carvacrol (CAR) showed various pharmacological and therapeutic effects in different disorders. In the current article, the experimental and clinical effects of CAR on respiratory, allergic, and immunologic disorders are described. Various databases, including PubMed, Science Direct, and Scopus, were searched regarding the effects of CAR on respiratory and allergic disorders until the end of October 2021. CAR showed the relaxant effect, with various possible mechanisms suggesting the bronchodilatory effect in obstructive pulmonary diseases. The preventive effects of CAR on experimental animal models of respiratory diseases were shown through mechanisms such as antioxidant, immunomodulatory, and anti‐inflammatory. CAR also showed therapeutic potential on lung cancer, lung infections, and allergic and immunologic disorders. Clinical studies also revealed therapeutic effects of CAR on asthma, sulfur‐mustard‐induced lug disorders, and some other allergic and immunologic diseases. Pharmacological and therapeutic effects of CAR indicate possible remedy effects of this agent in the treatment of respiratory, allergic, and immunologic diseases.

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Experimental and clinical evidence on the effect of carvacrol on respiratory, allergic, and immunologic disorders: A comprehensive review

2022

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Possible therapeutic effect of carvacrol on asthmatic patients: A randomized, double blind, placebo‐controlled, Phase II clinical trial

Alavinezhad

Khazdair

Boskabady

2017

Phytotherapy Research

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The relaxant effects of carvacrol, a phenolic monoterpene, on tracheal smooth muscle and its preventive effect on asthmatic animals were reported. The effect of carvacrol in asthmatic patients was examined in the placebo group (Group P, n = 11) receiving placebo and treatment group (Group C, n = 12), which received carvacrol capsule (1.2 mg/kg/day) for 2 months in a double-blind manner. Pulmonary function tests, respiratory symptoms, hematological indices, and high-sensitivity C-reactive protein (hs-CRP) were measured before, 1 and 2 months after starting treatment. At the end of treatment period, Pulmonary function tests values in Group C were significantly increased (p < .05 to p < .001). Most respiratory symptoms were also significantly reduced in Group C at the end of 2-month treatment (p < .05 to p < .001). Total and differential white blood cell (p < .05 to p < .001), as well as serum levels of hs-CRP in Group C were also significantly reduced after 2-month treatment with carvacrol (p < .001). Mean corpuscular hemoglobin concentration and hematocrit were changed in Group C (p < .05 and p < .01, respectively). However, in Group P, there was no significant changes in the evaluated parameters. Pulmonary function tests were increased but respiratory symptoms, inflammatory cells, and hs-CRP were reduced in asthmatic patients who received carvacrol that indicates its therapeutic effect on asthma.

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The effects of Nigella sativa on respiratory, allergic and immunologic disorders, evidence from experimental and clinical studies, a comprehensive and updated review

Saadat

Aslani

Ghorani

et al. 2021

Phytotherapy Research

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Nigella sativa (N. sativa) seed had been used traditionally due to several pharmacological effects. The updated experimental and clinical effects of N. sativa and its constituents on respiratory, allergic and immunologic disorders are provided in this comprehensive review article. Various databases including PubMed, Science Direct and Scopus were used. The preventive effects of N. sativa on pulmonary diseases were mainly due to its constituents such as thymoquinone, thymol, carvacrol and alpha-hederin. Extracts and constituents of N. sativa showed the relaxant effect, with possible mechanisms indicating its bronchodilatory effect in obstructive pulmonary diseases. In experimental animal models of different respiratory diseases, the preventive effect of various extracts and constituents of N. sativa was demonstrated by mechanisms such as antioxidant, immunomodulatory and antiinflammatory effects.Bronchodilatory and preventive effects of the plant and its components on asthma, COPD and lung disorders due to exposure to noxious agents as well as on allergic and immunologic disorders were also shown in the clinical studies. Various extracts and constituents of N. sativa showed pharmacological and therapeutic effects on respiratory, allergic and immunologic disorders indicating possible remedy effect of that the plant and its effective substances in treating respiratory, allergic and immunologic diseases.

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Relaxant effect of carvacrol, citronellal and p-cymene, monoterpenes present in Thymus and Cymbopogon species, in guinea-pig trachea: A comparative study

Cited by 9 publications

References 75 publications

Experimental and clinical evidence on the effect of carvacrol on respiratory, allergic, and immunologic disorders: A comprehensive review

Experimental and clinical evidence on the effect of carvacrol on respiratory, allergic, and immunologic disorders: A comprehensive review

Possible therapeutic effect of carvacrol on asthmatic patients: A randomized, double blind, placebo‐controlled, Phase II clinical trial

The effects of Nigella sativa on respiratory, allergic and immunologic disorders, evidence from experimental and clinical studies, a comprehensive and updated review

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