Anti-inflammatory, anti-hyperalgesic, antiplatelet and antiulcer activities of Byrsonima japurensis A. Juss. (Malpighiaceae)

Guilhon-Simplicio, Fernanda; Pinheiro, Carlos Cleomir de Souza; Conrado, Gabrielly Galdino; Barbosa, Gleyce dos Santos; Santos, Pierre Alexandre dos; Pereira, Maria de Meneses; Lima, Emerson Silva

doi:10.1016/j.jep.2012.01.018

Cited by 11 publications

(9 citation statements)

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“…The mass spectrometry analysis highlighted that the phenolic constitution of FEA is mainly composed of traces of gallic acid in association with high amounts of its corresponding ethyl ester. These results are in agreement with the observed anti-inflammatory actions of FEA, once antioxidant compounds like phenol acids and esters can inhibit the formation of peroxynitrite (ONOO − ) from the combination of superoxide radical (O 2 −• ) and nitric oxide (NO) released during the inflammatory response (membrane damage, lipid peroxidation) [11]. These reactive oxygen species (ROS) have been implicated in the pathogenesis of various diseases, including rheumatoid arthritis, asthma, atherosclerosis, and Alzheimer's disease and, furthermore, critically involved in various pain conditions, including neuropathic and inflammatory pains [30].…”

Section: Discussionsupporting

confidence: 83%

“…However, its pharmacological and chemical potential are still underexplored, since we already observed in vivo activities of other Amazonian Byrsonima species, Byrsonima japurensis , that has promising anti-inflammatory, analgesic, and antioxidant activities, corroborating its popular use [11]. Thereby, this study evaluated the chemical composition and the antioxidant, anti-inflammatory, and analgesic activities of the ethanolic extract and its fractions from the leaves of B. duckeana , in order to better evaluate its in vivo pharmacological potential.…”

Section: Introductionmentioning

confidence: 99%

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Analgesic, Anti-Inflammatory, and Antioxidant Activities of Byrsonima duckeana W. R. Anderson (Malpighiaceae)

Verdam

Guilhon-Simplicio

Andrade

et al. 2017

The Scientific World Journal

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Background. Byrsonima is a promising neotropical genus, rich in flavonoids and triterpenes, with several proven pharmacological properties. Nevertheless, Byrsonima duckeana W. R. Anderson is an Amazonian species almost not studied. Objective. To assess the antioxidant, anti-inflammatory, and analgesic activities of Byrsonima duckeana leaves. Materials and Methods. We analyzed an ethanol extract and its fractions for polyphenol content and UHPLC-MS/MS, phosphomolybdenum, DPPH, TBARS antioxidant tests, formalin-induced pain, carrageenan-induced peritonitis, acetic acid-induced abdominal writhings, and hot plate assays. Results. All the samples showed high polyphenol content and antioxidant capacity in the phosphomolybdenum, DPPH, and TBARS tests. We identified ethyl gallate, quinic acid, gallic acid, catechin, epicatechin, quercetrin, and quercetin in the samples. B. duckeana was able to reduce leukocyte migration in the carrageenan-induced peritonitis by 43% and the licking time in the formalin test by 57%. In the acetic acid-induced writhing test, the chloroform (FCL) and ethyl acetate (FEA) fractions were the most active samples. FEA was selected for the hot plate test, where all the dosages tested (5, 50, and 200 mg·kg−1) showed significant analgesic activity. Conclusion. B. duckeana has interesting analgesic and antioxidant activities, due to its high phenolic content, especially phenolic acids.

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Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Analgesic, Anti-Inflammatory, and Antioxidant Activities of Byrsonima duckeana W. R. Anderson (Malpighiaceae)

Verdam

Guilhon-Simplicio

Andrade

et al. 2017

The Scientific World Journal

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“…Research has confirmed a number of different biological activities in these plants, especially antioxidant, antimicrobial and topical and systemic anti-inflammatory activities. Phytochemically, this genus has been noted for the presence of flavonoids and triterpenoids [3]. …”

Section: Introductionmentioning

confidence: 99%

Mutagenicity and antimutagenicity of six Brazilian Byrsonima species assessed by the Ames test

Espanha

Resende

Neto

et al. 2014

BMC Complement Altern Med

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BackgroundIn various regions of Brazil, several species of the genus Byrsonima (Malpighiaceae) are widely used to treat gastrointestinal complications. This genus has about 150 species of shrubs and trees distributed over the entire Neotropical region. Various biological activities have been identified in these plants, especially antioxidant, antimicrobial and topical and systemic anti-inflammatory activities. The aim of this study was to investigate the mutagenicity and antimutagenicity of hydroalcoholic leaf extracts of six species of Byrsonima: B. verbascifolia, B. correifolia, B. coccolobifolia, B. ligustrifolia, B. fagifolia and B. intermedia by the Salmonella microsome assay (Ames test).MethodsMutagenic and antimutagenic activity was assessed by the Ames test, with the Salmonella typhimurium tester strains TA100, TA98, TA97a and TA102, with (+S9) and without (-S9) metabolization, by the preincubation method.ResultsOnly B. coccolobifolia and B. ligustrifolia showed mutagenic activity. However, the extracts of B. verbascifolia, B. correifolia, B. fagifolia and B. intermedia were found to be strongly antimutagenic against at least one of the mutagens tested.ConclusionsThese results contribute to valuable data on the safe use of medicinal plants and their potential chemopreventive effects. Considering the excellent antimutagenic activities extracted from B. verbascifolia, B. correifolia, B. fagifolia and B. intermedia, these extracts are good candidate sources of chemopreventive agents. However, B. coccolobifolia and B. ligustrifolia showed mutagenic activity, suggesting caution in their use.

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“…The extracts were obtained by an infusion of distilled water and 5% plant material for 15 min and dried by spray dryer (MSD 1.0, LabMaq, Ribeirão Preto, SP, Brazil) for further use (Guilhon‐Simplicio et al ., ). The extract content was analyzed in quadruplicate in accordance with Brazilian Pharmacopeia (Brasil, ).…”

Section: Methodsmentioning

confidence: 97%

“…Species of the Byrsonima genus (Malpighiaceae) are widely used in Brazilian traditional medicine, and antimicrobial, antioxidant, and anti‐inflammatory activities were present in some species (Guilhon‐Simplicio and Pereira, ). We have previously demonstrated the in vivo anti‐inflammatory and analgesic activities of the stem bark of Byrsonima japurensis , a medicinal plant known as ‘sara‐tudo’ (Guilhon‐Simplicio et al ., ; Guilhon‐Simplicio et al ., ), and recently, we also showed the in vivo analgesic and anti‐inflammatory activities of the leaves of Byrsonima duckeana (Verdam et al ., ). In both cases, the activities were closely related to antioxidant potential of the species.…”

Section: Introductionmentioning

confidence: 97%

Chemical Composition and Antioxidant, Antinociceptive, and Anti‐inflammatory Activities of Four Amazonian Byrsonima Species

Guilhon-Simplicio

Machado

Nascimento

et al. 2017

Phytotherapy Research

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Species of the Byrsonima genus are widely used in Brazil, especially for the treatment of gastrointestinal disorders. However, species from the Amazonian region are still poorly studied. Thus, we studied the antioxidant, antinociceptive, and anti-inflammatory activities of for Amazonian species, Byrsonima crispa, Byrsonima duckeana, Byrsonima garcibarrigae, and Byrsonima incarnata. Phenolic composition was determined by chemical and chromatographic methods. The aqueous extracts were evaluated in DPPH , ABTS , and superoxide (O ) tests, LPS-activated macrophage assay, and formalin test. All species contained a high phenolic and flavonoid content. We identified 15 phenolic compounds, including phenolic acids, hydroxycinnamic acids, flavonoids, and catechins. The extracts showed high antioxidant activity and were more active than quercetin at inhibiting nitric oxide release in the LPS-activated macrophage assay. B. duckeana and B. garcibarrigae showed higher in vivo antinociceptive and anti-inflammatory activities. B. garcibarrigae presented significant effect on the early phase of the formalin test, pointing to an antinociceptive mechanism distinct from traditional anti-inflammatory medicines. In conclusion, the pharmacological potential of these species is closely related to their flavonoid-rich chemical composition, which seems to act through antioxidant mechanisms. Copyright © 2017 John Wiley& Sons, Ltd.

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Anti-inflammatory, anti-hyperalgesic, antiplatelet and antiulcer activities of Byrsonima japurensis A. Juss. (Malpighiaceae)

Abstract: According to our results, it was concluded that stem bark of Byrsonima japurensis has significant and safe anti-inflammatory activity, which is closely related with their potent antioxidant activity, supporting the folk medicinal use of this species.

Cited by 11 publications

References 25 publications

Analgesic, Anti-Inflammatory, and Antioxidant Activities of Byrsonima duckeana W. R. Anderson (Malpighiaceae)

Analgesic, Anti-Inflammatory, and Antioxidant Activities of Byrsonima duckeana W. R. Anderson (Malpighiaceae)

Mutagenicity and antimutagenicity of six Brazilian Byrsonima species assessed by the Ames test

Chemical Composition and Antioxidant, Antinociceptive, and Anti‐inflammatory Activities of Four Amazonian Byrsonima Species

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