Anti-inflammatory, antinociceptive and diuretic activities of Trema orientalis Linn

Abstract

SUMMARYThe pharmacological interest coupled with traditional uses (antidiarrhoeal, antiseptic, analgesic etc) prompted us to test for anti-inflammatory, antinociceptive and diuretic activitities of Trema (T.) orientalis Linn. The crude methanolic leaves extract of T. orientalis was investigated for its possible anti-inflammatory activities using carrageenin induced rat paw edema model and cotton pellet implantation method in mice. Then the extract analyzed for its antinociceptive activities by acetic acid induced writhing model in mice. The extract possessed significant anti-inflammatory activity in both models at the doses of 200 and 400 mg/kg body weight of mice. Moreover, the extract showed significantly reduced the number of acetic acid-induced abdominal constriction in mice of 200 and 400 mg/kg body weight. The extract also showed positive diuretic activity in albino mice.

Diuretic effects and subacute toxicity of Trema orientalis Linn leave extract in wistar rats

“…Significant increase in Na + , K + Clion excretion (p < 0.05) was observed in treated animals at dose of 200 mg/kg but it was less than furosemide control and higher than the animal group who received distilled water. Compared to the work carried out by Uddin with the methanolic extract of Trema orientalis leaves, the elimination of ions in our rats fed with our hydromethanolic extract was lower 20 . This can be explained by the fact that our extract has less diuretic effect on our animals, reducing therefore the elimination of ions in the urine.…”

“…The diuretic activity evaluated with furosemide as positive control and distilled water as negative control, shows dose of 200 mg/kg of extract has low diuretic activity (Table 3) which confirmed the results obtained previously. The work of Uddin 20 on the diuretic potential of the methanolic extract of Trema orientalis leaves in mice at a dose of 200 and 400 mg/kg showed a diuretic potential comparable to furosemide. This difference in results can be explained by the fact that our extract contains a lower proportion of secondary metabolites which can contribute to a large increase in urinary output volume.…”

A review on anti-peptic ulcer activities of medicinal plants used in the formulation of Enterica, Dyspepsia and NPK 500 capsules

“…Investigation of the ethanolic leaves extract of the in Wistar rats using ethanol induced ulcer model showed a significant gastro protective activity comparable to pantoprazole [ 108 ]. Uddin and colleagues have also demonstrated a dose relative reduction in ulcer index when the ethanolic leaves extract of the plant at dosage quantities of 100 mg/kg, 150 mg/kg and 200 mg/kg were compared against pantoprazole as well as the controls [ 109 ]. Flavonoids are part of cytoprotective materials whose antiulcerogenic efficacy has been considerably confirmed [ 110 , 111 ].…”

“… Myrtaceae Leaves 1C [ 65 , 88 ] 4A [ 65 , 87 , 89 ] and 5A [ 65 ] 1 D, 4B and 5B Quercetin stigmasterol and ursolic acid [ 26 , 74 , 76 ] Trema orientalis Linn. Ulmaceae Stem bark, Leaves and roots 4A [ 108 , 109 ] 4B β sitosterol [ 75 ] Persea americana Mill. Lauraceae Leaves and fruits 1A and 4A [ 126 ] 1D and 4B Quercetin and quercetin-3-o-rhamnoside [ 74 , 75 ] Citrus aurantifolia Linn.…”