Anti-inflammatory, antinociceptive, antipyretic and antioxidant activities and phenolic constituents from Loranthus regularis Steud. ex Sprague

Mothana, Ramzi A.; Alsaid, Mansour S.; Al‐Rehaily, Adnan J.; Thabet, Tunis M.; Awad, Nasser A.; Lalk, Michael; Lindequist, Ulrike

doi:10.1016/j.foodchem.2011.07.048

Cited by 43 publications

(55 citation statements)

References 21 publications

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“…It is important to note that the doses of OR tested in this study 500, 1000 mg/kg significantly inhibited the number of writhes in comparison with the reference drug indomethacin . The hot plate test has been found suitable to evaluate central antinociceptive effect because of several advantages, particularly the sensitivity to antinociceptives and limited tissue damage 46 . Despite OR displayed a significant antinociception response on the acetic acid induced pain, all test samples showed no significant effects in hot-plate model, suggesting a non-participation on thermal stimulation associated with central neurotransmission in what the heat activates nociceptors.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory, Antinociceptive Activity of an Essential Oil Recipe Consisting of the Supercritical Fluid CO2 Extract of White Pepper, Long Pepper, Cinnamon, Saffron and Myrrh in vivo

Zhang

Wang

et al. 2014

J. Oleo Sci.

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Section: Discussionmentioning

confidence: 99%

Anti-inflammatory, Antinociceptive Activity of an Essential Oil Recipe Consisting of the Supercritical Fluid CO2 Extract of White Pepper, Long Pepper, Cinnamon, Saffron and Myrrh in vivo

Zhang

Wang

et al. 2014

J. Oleo Sci.

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“…The results of TLC and quantitative DPPH assays indicate that S. larvata presents, in general, low amounts of compounds with property of free radical scavenging. The antioxidant activity of the EtOAc extract can be due to the presence of phenolic compounds, which presents antioxidant activity by donating hydrogen atoms or electrons and thereby scavenges free radicals [22]. These findings are in accordance with the total phenolic content, which showed a low amount of these compounds in S. larvata extracts, comparing with other Smilax species [2].…”

Section: Discussionmentioning

confidence: 63%

“…Since the oxidative/nitrosative stress has been extensively associated with inflammation and different types of pain [22], substances with antioxidant properties have been proposed as adjuvant drugs to treat inflammation and pain. For this reason, in the next set of experiments, the possible antioxidant effect of SLG was also investigated.…”

Section: Discussionmentioning

confidence: 99%

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Phytochemical and Antinociceptive, Anti‐Inflammatory, and Antioxidant Studies of Smilax larvata (Smilacaceae)

Hirota

Paula

Oliveira

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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The tea of aerial parts of Smilax larvata Griseb. (Smilacaceae) has been ethnopharmacologically used in Southern Brazil due to its anti-inflammatory action. In this study, ethanolic and organic extracts from aerial parts of S. larvata were phytochemically and pharmacologically characterized. The phytochemical analysis of EtOAc extract of S. larvata revealed the presence of three flavonoids, drabanemoroside, kaempferol 3-O-α-L-rhamnopyranosyl(1→2)-α-L-rhamnopyranoside, and kaempferol, the first two being isolated for the first time in this genus, two phenolic compounds p-hydroxybenzoic acid and p-coumaric acid, and alkaloids. In vitro assays demonstrated a potential antioxidant property of SLG. The treatment with SLG induced a significant reduction of the formalin-evoked flinches in rats, an effect reversed by opioid antagonist naloxone. Treatment with SLG also induced a significant increase in the hot plate latency and a decrease of intestinal motility by 45%. No effect was observed over nociceptive responses induced by a TRPA1 agonist mustard oil or over acetic acid-induced writhing in mice. Together, our data suggested that SLG has an in vivo antinociceptive effect, which seems to be associated with the opioid system activation. These findings support previous claims of medical use of Smilax larvata in the treatment of pain conditions.

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“…The antioxidant activities of the lypholized extract were evaluated, using the β-carotene bleaching method described and modified by Mothana et al (2012). One milliliter of a 0.2 mg/mL β-carotene solution in chloroform was added to flasks containing 0.02 mL of linoleic acid and 0.2 mL of Tween-20.…”

Section: Scavenging Activity Of Dpph Radicalmentioning

confidence: 99%

Red Cabbage (Brassica oleraceaL.) Mediates Redox-Sensitive Amelioration of Dyslipidemia and Hepatic Injury Induced by Exogenous Cholesterol Administration

Al‐Dosari

2014

Am. J. Chin. Med.

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The widely used culinary vegetable, red cabbage (Brassica oleracea L. Var. capitata f. rubra), of the Brassicaceae family contains biologically potent anthocyanins and a myriad of antioxidants. Previous studies have shown that the pharmacological effects of red cabbage in vivo are redox-sensitive. The present study explored whether red cabbage modulates various histopathological and biochemical parameters in rats administered with a cholesterol-rich diet (CRD). To this end, prolonged administration of a lyophilized-aqueous extract of red cabbage (250 and 500 mg/kg body weight) significantly blunted the imbalances in lipids, liver enzymes and renal osmolytes induced by the CRD. The effects of red cabbage were compared to simvastatin (30 mg/kg body weight) treated rats. Estimation of malondialdehyde and non-protein sulfhydryls revealed robust antioxidant properties of red cabbage. Histopathological analysis of livers from rats administered with red cabbage showed marked inhibition in inflammatory and necrotic changes triggered by CRD. Similarly, in vitro studies using a 2',7'-Dichlorofluorescein-based assay showed that red cabbage conferred cytoprotective effects in cultured HepG2 cells. In conclusion, the present study discloses the potential therapeutic effects of red cabbage in dyslipidemia as well as hepatic injury, that is at least, partly mediated by its antioxidant properties.

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Anti-inflammatory, antinociceptive, antipyretic and antioxidant activities and phenolic constituents from Loranthus regularis Steud. ex Sprague

Cited by 43 publications

References 21 publications

Anti-inflammatory, Antinociceptive Activity of an Essential Oil Recipe Consisting of the Supercritical Fluid CO2 Extract of White Pepper, Long Pepper, Cinnamon, Saffron and Myrrh in vivo

Anti-inflammatory, Antinociceptive Activity of an Essential Oil Recipe Consisting of the Supercritical Fluid CO2 Extract of White Pepper, Long Pepper, Cinnamon, Saffron and Myrrh in vivo

Phytochemical and Antinociceptive, Anti‐Inflammatory, and Antioxidant Studies of Smilax larvata (Smilacaceae)

Red Cabbage (Brassica oleraceaL.) Mediates Redox-Sensitive Amelioration of Dyslipidemia and Hepatic Injury Induced by Exogenous Cholesterol Administration

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