Anti-inflammatory Benzenoids from <i>Antrodia </i><i>camphorata</i>

Chen, Jih Jung; Lin, Wen Jiou; Liao, Chia-Shu; Shieh, Po Chuen

doi:10.1021/np070045e

Cited by 110 publications

(108 citation statements)

References 24 publications

Supporting

Mentioning

105

Contrasting

Order By: Relevance

“…[13][14][15] Studies on structure-activity relationships suggested that the introduction of the allenyl moiety could generate or enhance cytotoxicity of these compounds. 8 Alkynes are important bioactive natural products showing cytotoxic, anti-inflammatory, and antiprotozoal effects [16][17][18] and are commonly used as the building blocks in synthesis of allenyl natural products. [19][20][21][22] Compounds 1-6 are the first secondary metabolites to be reported from the endolichenic fungus Neurospora sp.…”

Section: Resultsmentioning

confidence: 99%

Allenyl and Alkynyl Phenyl Ethers from the Endolichenic Fungus Neurospora terricola

Zhang¹,

Liu²,

Lu³

et al. 2009

J. Nat. Prod.

View full text Add to dashboard Cite

Terricollenes A−C (1−3), new allenyl phenyl ethers, and terricolynes (4−6), new alkynyl phenyl ethers, have been isolated from the crude extract of the endolichenic fungus Neurospora terricola. The structures of these compounds were elucidated primarily by NMR experiments. The absolute configurations of 1 and 2 were determined by reversed-phase HPLC analysis on the o-tolylthiocarbamates of the liberated sugars upon acid hydrolysis, whereas that of 4 was assigned using the modified Mosher method. Compound 1 showed modest cytotoxicity against the human tumor cell lines HeLa and MCF-7.

show abstract

Section: Resultsmentioning

confidence: 99%

Allenyl and Alkynyl Phenyl Ethers from the Endolichenic Fungus Neurospora terricola

Zhang¹,

Liu²,

Lu³

et al. 2009

J. Nat. Prod.

View full text Add to dashboard Cite

show abstract

“…This feature allows its application as a charged chiral selector over a wide pH range [2][3][4][5][6][7][8][9][10][11][12]. Except for the switching between AC1 and AC4, increasing pH from 7 to 9.3 largely unaffected the migration order of the other isolates.…”

Section: Effect Of Buffer Ph and Organic Modifier On Separationmentioning

confidence: 99%

“…The fruiting body of A. camphorata has been known to consist of several components including steroids, triterpenoids, sesquiterpenes, lignoids, fatty acids, phenyl methanoids, and its dimers [14,16-17, 20, 29-32]. Then, four new compounds, including three new benzenoids, antrocamphin A, antrocamphin B, and 2,3,4,5-tetramethoxybenzoyl chloride, and a new 1,3-dioxolan-2-one derivative, antrodioxolanone, together with 13 known compounds have been isolated from the fruiting body of A. camphorata [10]. In addition, several new compounds including 10-hydroxy-gdodecalactone, 11-hydroxy-g-dodecalactone, 2-(2-hydroxyethyl)phenol, 12-hydroxydodecanoic acid methyl ester [33], and antroquinonol [34] were recently isolated from the submerged whole broth of A. camphorata.…”

Section: Migration Ordermentioning

confidence: 99%

“…It has also been used in the formulation of nutraceuticals and functional foods in Taiwan to enhance the immune system and liver function [1]. To date, this edible fungus exhibits several important biological activities: anticancer [2][3][4][5], antihepatotoxic [6,7], antihypertensive [8], anti-inflammatory [9,10], antioxidant [11], and neuroprotective activities [12]. A. camphorata inhibits lipopolysaccharide/inteferon (LPS/ IFN)-g-induced inflammatory mediator production in macrophages, as well as tumor cell proliferation [13].…”

Section: Introductionmentioning

confidence: 99%

“…A. camphorata inhibits lipopolysaccharide/inteferon (LPS/ IFN)-g-induced inflammatory mediator production in macrophages, as well as tumor cell proliferation [13]. Previous phytochemical investigations on A. camphorata have resulted in the isolation of diterpenoids, triterpenoids, sesquiterpene lactone, benzenoids, and polysaccharides [10,12,[14][15][16][17][18][19][20]. To date, three triterpenoids named antcin A (AC6), antcin B (AC3), and antcin C (AC7) with ergostane skeletons in the fruiting body of A. camphorata were first isolated and identified [16].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cyclodextrin‐modified capillary electrophoresis for achiral and chiral separation of ergostane and lanostane compounds extracted from the fruiting body of Antrodia camphorata

et al. 2009

View full text Add to dashboard Cite

A CD-modified capillary electrophoretic method has been developed for achiral and chiral analysis of seven bioactive compounds isolated from the fruiting body of Antrodia camphorata. Such important target analytes exhibit similar chemical structures and are known for their diverse properties including antioxidant and anticancer effects. The analytes were separated in 25 min using a pH 9.3, 20 mM sodium borate buffer containing 20 mM methyl-b-CD and 30 mM sulfobutylether-b-CD. With the exception of the optical isomer pairs (antcin B or zhankuic acid A, zhankuic acid C, and antcin A), the remaining bioactive compounds including the chiral pair antcin C were baseline-separated. Analysis time was noticeably longer to baseline separate all of the above chiral pairs ($38 min) by adding 5% DMF to the running buffer. The migration order was reversed compared with the HPLC elution. More hydrophobic compounds complexed favorably with methyl-b-CD and emerged earlier in the electropherogram than their more hydrophilic counterparts which were strongly associated with sulfobutylether-b-CD. The simple capillary electrophoretic method developed was applicable for rapid separation and characterization of several important bioactive compounds isolated from the fruiting body of A. camphorata.

show abstract

Effect of cultural conditions on antrodin C production by basidiomycete Antrodia camphorata in solid‐state fermentation

Xia

Wang²,

Zhang

et al. 2014

Biotech and App Biochem

View full text Add to dashboard Cite

Antrodia camphorata is a medicinal fungus and antrodin C is one of the main bioactive components of A. camphorata in the submerged fermentation (SmF). To optimize the culture conditions, the factors influencing the production of antrodin C by A. camphorata under solid-state fermentation (SSF) were investigated in this study. Different solid substrates and external nitrogen sources were tested for their efficiency in producing antrodin C. The response surface methodology was applied to evaluate the influence of several variables, namely, the concentrations of soybean meal, initial moisture content, and inoculum density on antrodin C production in solid-state fermentation. The experimental results show that the optimum fermentation medium for antrodin C production by A. camphorata was composed of 0.578 g soybean meal, 0.05 g Na2 HPO4 , 0.05 g MgSO4 for 100 g rice, with 51.83% initial moisture content, 22 day culture time, 28 °C culture temperature, and 35.54% inoculum density. At optimized conditions, 6,617.36 ± 92.71 mg kg(-1) yield of antrodin C was achieved. Solid-state fermentation is one good cultural method to improve the production of antrodin C by A. camphorata.

show abstract

Anti-inflammatory Benzenoids from Antrodia camphorata

Cited by 110 publications

References 24 publications

Allenyl and Alkynyl Phenyl Ethers from the Endolichenic Fungus Neurospora terricola

Allenyl and Alkynyl Phenyl Ethers from the Endolichenic Fungus Neurospora terricola

Cyclodextrin‐modified capillary electrophoresis for achiral and chiral separation of ergostane and lanostane compounds extracted from the fruiting body of Antrodia camphorata

Effect of cultural conditions on antrodin C production by basidiomycete Antrodia camphorata in solid‐state fermentation

Contact Info

Product

Resources

About