Anti-inflammatory Compounds from the Bitter Mushroom,<i>Sarcodon scabrosus</i>

Hirota, Mitsuru; Morimura, Keiji; Shibata, Hisao

doi:10.1271/bbb.66.179

Cited by 41 publications

(25 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…From S. scabrosus in addition to the already mentioned sarcodonins A (21) and G (22) in 2002 other three cyathane diterpenoids have been isolated (Hirota et al, 2002). Three of them were named neosarcodonins A-C (31-33).…”

Section: Phytochemistry Of Sarcodon Scabrosusmentioning

confidence: 99%

See 1 more Smart Citation

Sarcodon Mushrooms: Biologically Active Metabolites

Marcotullio¹

2011

Phytochemicals - Bioactivities and Impact on Health

View full text Add to dashboard Cite

Section: Phytochemistry Of Sarcodon Scabrosusmentioning

confidence: 99%

“…Anti-inflammatory activity has been tested for sarcodonin A (21), sarcodonin G (22), neosarcodonin A-C (31-33) (Hirota et al, 2002), neosarcodonin O (34), acyl derivatives of sarcodonin A (35-37) (Kamo et al, 2004) and glaucopines A-C (5-7) (Curini et al, 2005;Marcotullio et al, 2006a). The results are reported in Table 2.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Sarcodon Mushrooms: Biologically Active Metabolites

Marcotullio¹

2011

Phytochemicals - Bioactivities and Impact on Health

View full text Add to dashboard Cite

“…(koumoritake) and the diterpenes such as sarcodonin A and neosarcodonin A in Sarcodon scabrosus (kerouji) were anti-inflammatory compounds. 16,17) Cycloleucomelone-leucodi-hexaacetate in Boletopsis leucomelas (kurokawa), and grifolin and the analogues of grifolic acid in Albatrellus dispansus (Lloyd) Canf. et Gilbm.…”

Section: Anti-allergic Activities Of Ergosterol Mannitol Trehalosementioning

confidence: 99%

Preventive Effects of 80% Ethanol Extracts of the Edible Mushroom Hypsizigus marmoreus on Mouse Type IV Allergy

Yoshino

Kondou

Ishiyama

et al. 2008

JOURNAL OF HEALTH SCIENCE

View full text Add to dashboard Cite

We investigated the active components responsible for the anti-allergic effect of Hypsizigus marmoreus on an oxazolone-induced type IV allergy in male ICR mice. Following both an oral administration at a dose of 250 mg/kg body weight and percutaneous administration at 0.10 mg/ear, significant anti-allergic activities were found in the 80% ethanolsoluble fraction (Fr. 1), and the low molecular weight fraction (Fr. 2, below a molecular weight of ca. 12000; Fr. 4, below ca. 3000) prepared from Fr. 1. These fractions included ergosterol, mannitol, and trehalose as antioxidants and/or anti-inflammatory components. The anti-allergic activities of these compounds and methionine were equal to or weaker than those of the fractions. Therefore, the molecular weights of the major active components in Hypsizigus marmoreus are thought to be less than ca. 3000, though ergosterol, mannitol, trehalose, and methionine would not be the main active components.

show abstract

“…The genus Sarcodon includes some species with therapeutic potentials, e.g., Sarcodon aspratus was found effective in antitumor activity and Sarcodon scabrosus in anti-inflammatory actions [3][4][5]. Interesting biological properties of this genus are associated with the occurrence of ergosterol peroxide (3β-hydroxy-5α,8α-epidioxyergosta-6,22-dien), which exhibits a series of activities such as antileukemic and antitumor [6] and inflammatory activity [7].…”

Section: Introductionmentioning

confidence: 99%

Chemical compounds of extracts from Sarcodon imbricatus at optimized growth conditions

et al. 2016

View full text Add to dashboard Cite

The effect of carbon and nitrogen sources and initial pH and temperature of the medium on the mycelial growth of Sarcodon imbricatus (L.) P. Karst. in axenic liquid culture was investigated. The optimal composition of the medium was found to be: 5% fructose, 1% hydrolysate of casein, 1% yeast extract, and 0.3% KH 2 PO 4 at pH = 6 and incubation temperature of 20°C. In this condition the maximum biomass growth was observed, yielding 10.2 g L −1 of dry weight after 3-week of growth. The medium regarded as optimal for growth of S. imbricatus mycelium was used for the production of the biomass and further chemical analysis. The quantitative and qualitative composition of phenolic acids, fatty acids, and sterols were determined using chromatographic methods. The total content of phenolic acids was 1.86 mg × 100 g −1 DW, with the largest amount of protocatechuic acid (1.27 mg × 100 g −1 DW). Nineteen fatty acids were estimated, including five unsaturated fatty acids, e.g., oleic and α-linolenic acid. The analysis of sterols composition revealed the presence of ergosterol and ergosterol peroxide (197.7 and 200.47 mg × 100 g −1 DW, respectively). These compounds were isolated and confirmed by 1 H-NMR. Presented study constitutes the first report on the accumulation of substances (phenolic acids, fatty acids, and sterols) with multidirectional biological activity in the mycelial axenic culture of Sarcodon imbricatus.

show abstract

Anti-inflammatory Compounds from the Bitter Mushroom,Sarcodon scabrosus

Cited by 41 publications

References 8 publications

Sarcodon Mushrooms: Biologically Active Metabolites

Sarcodon Mushrooms: Biologically Active Metabolites

Preventive Effects of 80% Ethanol Extracts of the Edible Mushroom Hypsizigus marmoreus on Mouse Type IV Allergy

Chemical compounds of extracts from Sarcodon imbricatus at optimized growth conditions

Contact Info

Product

Resources

About