Anti-inflammatory constituents from<i>Perovskia atriplicifolia</i>

Ahmad, Ijaz; Waheed, Abdul; Tahir, Nafisa Batool; Rais, Aisha Kalsoom

doi:10.3109/13880209.2014.997250

Cited by 13 publications

(11 citation statements)

References 10 publications

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“…Anti-inflammatory properties were also studied on several lignans isolated from chloroform extract of P. atriplicifolia leaves. [ 4 ] Taxiresinol was the most potent among six compounds and inhibited leukotriene C4 release from rat basophiles with IC 50 of 3.49 μM. However, in our study, we did not detect these lignans in the hydromethanolic extract, probably because chloroform is a better solvent for obtaining nonpolar compounds.…”

Section: Discussioncontrasting

confidence: 67%

“…[ 1 2 3 ] Other compounds present in different parts of this plant include other phenolic acids, lignans, flavonoids, and di- and triterpenoids. [ 2 4 5 6 7 8 9 ] P. atriplicifolia is used as folk medicine to treat a variety of ailments, including diabetes. [ 10 11 12 ] However, the anecdotic information on the antidiabetic use of Perovskia sp.…”

Section: Introductionmentioning

confidence: 99%

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Inhibition of glycation-induced cytotoxicity, protein glycation, and activity of proteolytic enzymes by extract from Perovskia atriplicifolia Roots

Miroliaei¹,

Aminjafari²,

Ślusarczyk³

et al. 2017

Phcog Mag

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Background:Protein glycation and glycotoxicity belong to the main oxidative-stress related complications in diabetes. Perovskia species are used in Asian folk medicine as antidiabetic herbs.Objective:The aim of this study was to verify the ability of the methanolic extract from Perovskia atriplicifolia Benth. roots to diminish glycation of albumin and to prevent cell damage in vitro. Furthermore, we tested the extract for in vitro antioxidant activity and inhibition of elastase and collagenase.Material and Methods:The aqueous methanol extract was analyzed by UHPLC-MS for the content of polyphenols and terpenoids. The prevention of glycated albumin-induced cell damage was tested in four mammalian cell lines (peripheral blood mononuclear cells, human embryonic kidney cells – HEK293, normal human fibroblasts, and Chinese hamster ovary cells) with the 5-(3-carboxymethoxyphenyl)-2-(4,5-dimethylthiazoly)-3-(4-sulfophenyl) tetrazolium assay.Results:Glycated albumin is significantly more toxic than native human serum albumin (LC50 from 35.00 to 48.34 μg/mL vs. 5.47–9.10 μg/mL, respectively). The extract, rich in rosmarinic acid (344.27 mg/g dry mass), mitigated the glycated albumin toxicity, and increased glycated albumin-treated cell survival by more than 50%. The inhibition of advanced glycation endproduct formation was confirmed by monitoring conformational changes. The free radical scavenging activity was higher than Trolox and metal reducing power was one-third to half that of ascorbic acid. The activity of elastase and collagenase was inhibited by 54.75% ± 6.87% and 60.03% ± 7.22%, respectively.Conclusions:The results confirm antiglycative and antiglycotoxic potential of Perovskia root and its traditional antidiabetic use. The high activity can be attributed to rosmarinic acid abundance.SUMMARY Perovskia is a small genus of aromatic shrubby plants growing in arid regions of Central and South Asia. Different parts are used in folk medicine as antiparasitic, anti-infectious and antidiabetic remedy. Here, we have studied the extract from roots for inhibition of: glycation-induced cytotoxicity, human serum albumin glycation, inflammation-related enzymes, as well as for antioxidant activity. Result: the extract from P. atriplicifolia roots inhibited protein glycation and AGE-induced toxicity in cell cultures. The mechanism is likely to rely on the antioxidant activity of high content of rosmarinic acid. Abbreviations used: AGE: advanced glycation end-products; DPPH: 2,2-diphenyl-1-picrylhydrazyl; HSA: human serum albumin.

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Section: Discussioncontrasting

confidence: 67%

Section: Introductionmentioning

confidence: 99%

Inhibition of glycation-induced cytotoxicity, protein glycation, and activity of proteolytic enzymes by extract from Perovskia atriplicifolia Roots

Miroliaei¹,

Aminjafari²,

Ślusarczyk³

et al. 2017

Phcog Mag

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“…It has also been reported to possess antibacterial and anti‐inflammatory activities. [ ][ ] Some investigation on this plant has been conducted and many compounds has been isolated . Our previous investigation suggested that the petroleum ether extract of P .…”

Section: Introductionmentioning

confidence: 99%

Four New Diterpene Glucosides from Perovskia atriplicifolia

Zhou

Zhu

Zhang

et al. 2017

Chemistry & Biodiversity

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Four new diterpene glucosides, namely perovskiaditerpenosides A - D (1 - 4), were isolated from the BuOH extract of Perovskia atriplicifolia. Their structures were well elucidated by chemical methods and comprehensive spectroscopic analyses including MS, IR, and NMR (1D and 2D). The newly isolated compounds were screened for their cytotoxic activity against HepG2, NB4, HeLa, K562, MCF7, PC3, and HL60. The obtained results indicated that the new compounds possessed considerable cytotoxic activity.

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“…SSG is a natural furofuran-type lignan with a glucose linked to the benzene ring. Its aglycone, syringaresinol, possesses diverse pharmacological activities including anti-hepatic fibrosis 7 , anticancer 8 , antithrombotic 13 , as well as ant-inflammatory 14 , cardiomyocytic protection 15 , and vascular relaxation 16 . Various mechanisms are involved in syringaresinol-mediated health benefits such as protection cells from damage 15 , stimulation cell cycle arrest 8 and enhancing nitric oxide (NO) production.…”

Section: Introductionmentioning

confidence: 99%

Syringaresinol-4- O - β - d -glucoside alters lipid and glucose metabolism in HepG2 cells and C2C12 myotubes

Wang

et al. 2017

Acta Pharmaceutica Sinica B

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Syringaresinol-4-O-β-d-glucoside (SSG), a furofuran-type lignan, was found to modulate lipid and glucose metabolism through an activity screen of lipid accumulation and glucose consumption, and was therefore considered as a promising candidate for the prevention and treatment of metabolic disorder, especially in lipid and glucose metabolic homeostasis. In this study, the effects of SSG on lipogenesis and glucose consumption in HepG2 cells and C2C12 myotubes were further investigated. Treatment with SSG significantly inhibited lipid accumulation by oil red O staining and reduced the intracellular contents of total lipid, cholesterol and triglyceride in HepG2 cells. No effect was observed on cell viability in the MTT assay at concentrations of 0.1–10 μmol/L. SSG also increased glucose consumption by HepG2 cells and glucose uptake by C2C12 myotubes. Furthermore, real-time quantitative PCR revealed that the beneficial effects were associated with the down-regulation of sterol regulatory element-binding proteins-1c, -2 (SREBP-1c, -2), fatty acid synthase (FAS), acetyl CoA carboxylase (ACC) and hydroxyl methylglutaryl CoA reductase (HMGR), and up-regulation of peroxisome proliferator-activated receptors alpha and gamma (PPARα and PPARγ). SSG also significantly elevated transcription activity of PPARγ tested by luciferase assay. These results suggest that SSG is an effective regulator of lipogenesis and glucose consumption and might be a candidate for further research in the prevention and treatment of lipid and glucose metabolic diseases.

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Anti-inflammatory constituents fromPerovskia atriplicifolia

Cited by 13 publications

References 10 publications

Inhibition of glycation-induced cytotoxicity, protein glycation, and activity of proteolytic enzymes by extract from Perovskia atriplicifolia Roots

Inhibition of glycation-induced cytotoxicity, protein glycation, and activity of proteolytic enzymes by extract from Perovskia atriplicifolia Roots

Four New Diterpene Glucosides from Perovskia atriplicifolia

Syringaresinol-4- O - β - d -glucoside alters lipid and glucose metabolism in HepG2 cells and C2C12 myotubes

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