Anti-inflammatory diterpenoids from the Brazilian alga Dictyota menstrualis

Ávila, Fábio do Nascimento; Souza, Luciana Gregório da Silva; Carneiro, Pedro Bastos de Macêdo; Santos, Flávia Almeida; Sasahara, Greyce Luri; Filho, José Delano Barreto Marinho; Araújo, Ana Jérsia; Barros, Ayslan Batista; Monteiro, Norberto de Kássio Vieira; Silveira, Edilberto R.; Pessoa, Otília Deusdênia Loiola

doi:10.1016/j.algal.2019.101695

Cited by 4 publications

(2 citation statements)

References 44 publications

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“…Anti-inflammatory, antimicrobial, and cytotoxic assays were performed with the isolated compounds, but only the anti-inflammatory activity was particularly prominent. The cell viability effects of the detected compounds on the murine macrophage cell line RAW 264.7 showed IC 50 values from 1.12 to 2.53 µM, and the inhibitory activity against the nitric oxide production over the lipopolysaccharidestimulated RAW 264.7 cell line was observed for all compounds, with IC 50 values ranging from 0.12 to 0.23 mM [103].…”

Section: Dictyota Menstrualis (Hoyt) Schnetter Hörning and Weber-peukert 1987mentioning

confidence: 96%

The Biodiversity of the Genus Dictyota: Phytochemical and Pharmacological Natural Products Prospectives

et al. 2022

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Although a broad variety of classes of bioactive compounds have already been isolated from seaweeds of the genus Dictyota, most different species are still chemically and biologically unexplored. Dictyota species are well-known brown seaweeds belonging to the Dictyotaceae (Phaeophyta). The phytochemical composition within the genus Dictyota has recently received considerable interest, and a vast array of components, including diterpenes, sesquiterepenes, sterols, amino acids, as well as saturated and polyunsaturated fatty acids, have been characterized. The contribution of these valued metabolites to the biological potential, which includes anti-proliferative, anti-microbial, antiviral, antioxidant, anti-inflammatory, and anti-hyperpigmentation activities, of the genus Dictyota has also been explored. Therefore, this is the most comprehensive review, focusing on the published literature relevant to the chemically and pharmacologically diverse biopharmaceuticals isolated from different species of the genus Dictyota during the period from 1976 to now.

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Section: Dictyota Menstrualis (Hoyt) Schnetter Hörning and Weber-peukert 1987mentioning

confidence: 96%

The Biodiversity of the Genus Dictyota: Phytochemical and Pharmacological Natural Products Prospectives

et al. 2022

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“…There is particular interest in several species of this family, being notable Dictyota menstrualis and Canistrocarpus cerviconis. Extracts of these algae, which are typically found in shallow waters and intertidal communities in subtropical and tropical areas (Sadeghi et al, 2019), exhibit a remarkably wide range of properties (Chen et al, 2018;Bogaert et al, 2020), effects of the following types: antiviral (Pereira et al, 2004;Abrantes et al, 2010;Vallim et al, 2010;Cavalcanti et al, 2011;de Souza Barros et al, 2016;Cirne-Santos et al, 2019;Cirne-Santos et al, 2020a;Cirne-Santos et al, 2020b;Ribeiro et al, 2021), cytotoxic (Jongaramruong and Kongkam, 2007;Caamal-Fuentes et al, 2014), antibacterial (Viano et al, 2009;Ibraheem et al, 2017;de Figueiredo et al, 2019;Rubiano-Buitrago et al, 2019), antitumoral (Gomes et al, 2015), anti-snake venom effect (Domingos et al, 2011), anti-inflammatory (Albuquerque et al, 2013;do Nascimento A ́vila et al, 2019), anticoagulant (Albuquerque et al, 2004;Camara et al, 2011;de Andrade Moura et al, 2011), antioxidant (Rodrigues et al, 2020), and antileishmanial (Dos . Thus, D. menstrualis and C. cervicornis were selected as the target of the present study because they are species with widely demonstrated different bioactivities and pharmacological potential.…”

Section: Introductionmentioning

confidence: 99%

Influence of laboratory conditions on two species Dictyotaceae family (Phaeophyceae): Diterpenoid profile and physiological response

et al. 2023

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The seaweed Dictyotaceae family has a great wealth of diterpenes with important biological activities. Information on these diterpenes qualitative and quantitative aspects in conjunction with physiological data and abiotic parameters are essential to obtain an effective algal culture system that is a sustainable resource. In this study, the diterpene profile of Dictyota menstrualis and Canistrocarpus cervicornis were analyzed as a function of in vitro maintenance time and the influence of culture medium. The algae were collected in the state of Rio de Janeiro and subjected to an acclimation period in the laboratory. Then, the species were acclimated in aquaria containing seawater from the collection sites. Then biomass algal was divided into (i) control experiment (CC): Growth in sterilized seawater; (ii) enriched experiment (EE): Growth in sterilized seawater enriched with Provasoli/2. Triplicate experiments were maintained in vitro (2.4% m/v), and the medium was changed every 7 days. Diterpenes were monitored using dichloromethane extracts from dried algae: (a) collected in the field, (b) after the acclimation period, and (c) from experimental units taken every 7 days for a total of 21 days. Among the main results, we found response variables such as specific growth rate (SGR); moreover, positive data were obtained for the alga C. cervicornis in CC, and this was evident showing after 7 days of cultivation in the experimental control unit (CU). For D. menstrualis, the SGRs for the treatments were negative at the monitored time, which was due to biomass losses, frond breakage, and rapid decomposition of some individuals that did not withstand the stress conditions during their collection. The analysis of the chemical profile by GC-MS made it possible to monitor 12 diterpenes and one sterol in the alga D. menstrualis and 7 diterpenes in C. cervicorni. The correlations found by Generalized Linear Models (GLMs) and redundancy analysis (RDA) statistical analyzes between the diterpene profile with the monitored variables (Nitrate, ammonia and pH), showed correlations for 10 diterpenes of the species D. menstrualis and 1 of the C. cervicornis, our analyses are important for the discussion of metabolic plasticity of the Dictyotaceae family

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Chemical variation and analysis of diterpenes from seaweed Dictyota menstrualis under controlled conditions

et al. 2022

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Anti-inflammatory diterpenoids from the Brazilian alga Dictyota menstrualis

Cited by 4 publications

References 44 publications

The Biodiversity of the Genus Dictyota: Phytochemical and Pharmacological Natural Products Prospectives

The Biodiversity of the Genus Dictyota: Phytochemical and Pharmacological Natural Products Prospectives

Influence of laboratory conditions on two species Dictyotaceae family (Phaeophyceae): Diterpenoid profile and physiological response

Chemical variation and analysis of diterpenes from seaweed Dictyota menstrualis under controlled conditions

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