Anti-inflammatory drug nanocrystals: state of art and regulatory perspective

Synthesis of Chitosan/Diatomite Composite as an Advanced Delivery System for Ibuprofen Drug; Equilibrium Studies and the Release Profile

“…Inflammation refers to the response of biological organisms to different infections, which might cause more damages than the main infection. , Several drugs such as azithromycin, ibuprofen, and levofloxacin were used to decline such inflammations effects. , Ibuprofen (IB) is a widely applied anti-inflammatory drug that has analgesic properties for musculoskeletal disorders and rheumatoid arthritis . The normal use of ibuprofen faces significant challenges in the medical society due to its fast degradation properties (3.5 as half-life), poor bioavailability, low solubility, and high permeability .…”

“…Interested researchers have developed several methods to enhance the stability; bio-distribution, solubility, and selectivity of the IB drug in addition to the role of such techniques in controlling the released dosages of the drug, improving the patient compliance, and inducing its therapeutic efficiency. − Introducing the drug at gradual delivery, managed dose, aggressively pursued, and targeted delivery using innovative carriers were recommended as promising methods to avoid all of the reported side effects. ,, The studied carriers for the IB drug involved mesoporous silica, hydroxyapatite, montmorillonite, titanium alloy, and MOFs. ,, …”

“…INTRODUCTION Inflammation refers to the response of biological organisms to different infections, which might cause more damages than the main infection. 1,2 Several drugs such as azithromycin, ibuprofen, and levofloxacin were used to decline such inflammations effects. 3,4 Ibuprofen (IB) is a widely applied anti-inflammatory drug that has analgesic properties for musculoskeletal disorders and rheumatoid arthritis.…”

Biomimetic Citrate-Coated Luminescent Apatite Nanoplatforms for Diclofenac Delivery in Inflammatory Environments

“…Nanotechnology is finding increasing applications in medicine; in particular nanoparticles (NPs) can be used as vehicles to transport and deliver different classes of biologically active molecules (so-called nanocarriers), including chemotherapeutics, antibiotics, anti-inflammatory drugs, hormones, fluorophores, targeting agents [ 1 , 2 , 3 , 4 , 5 , 6 , 7 ], depending on the pathology considered, acting both in diagnosis and therapy. Their main advantage is linked to their nanoscale dimensions, enabling them to carry high amounts of molecules to chosen body sites, in the meantime protecting the drugs from rapid degradation or clearance.…”

Insight into the Technical Qualification of the Sonocogreen CaO/Clinoptilolite Nanocomposite (CaO(NP)/Clino) as an Advanced Delivery System for 5-Fluorouracil: Equilibrium and Cytotoxicity

“…Therefore, synthetic carriers and delivery systems with significant chemical and structural properties were assessed to avoid the reported side effects of the 5-FL drug and to enhance its therapeutic effect . Synthetic carriers are used essentially to deliver the loaded 5-FL drug at managed dosage, systematic diffusion rate, aggressively pursued, and targeted pathways. , The introduced carriers in the later periods show considerable effects on (1) inducing the solubility of the 5-FL drug, (2) controlling its diffusion rate, (3) inducing its selectivity properties toward the target cells, (4) declining its degradation rate, (5) promoting the patient compliance, (6) keeping its concentration at the required therapeutic value, and (7) inducing the pharmacological and curative profiles. ,− The materials introduced as carriers for 5-FL drugs in the recent periods included biodegradable polymers, kaolinite and halloysite, , zeolite, MCM-based materials, clay-based minerals, , and layered double hydroxides …”