1976
DOI: 10.1007/bf01971577
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Anti-inflammatory drugs, prostaglandins and leucocyte migration

Abstract: The action of some non-steroidal acidic anti-inflammatory drugs, aspirin, phenylbutazone and indomethacin, in reducing leucocyte migration into the exudates of inert porous sponges implanted subdermally in the rat has been shown to be distinct from their effect in reducing the content of prostaglandins in the exudates. It is concluded that a component of the anti-inflammatory and antirheumatic actions of the drugs is concerned with a mechanism other than inhibition of prostaglandin biosynthesis.

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Cited by 135 publications
(31 citation statements)
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“…The results obtained with the standard drugs essentially confirm those of others who also found that these drugs reduced prostaglandin levels in rat inflammatory exudates [6,15,[19][20][21]. Indomethacin, like fenclofenac, markedly inhibits prostaglandin synthesis at doses lacking acute anti-inflammatory activity; indeed, the margin between these activities may be greater than that observed with fenclofenac.…”
Section: Discussionsupporting
confidence: 93%
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“…The results obtained with the standard drugs essentially confirm those of others who also found that these drugs reduced prostaglandin levels in rat inflammatory exudates [6,15,[19][20][21]. Indomethacin, like fenclofenac, markedly inhibits prostaglandin synthesis at doses lacking acute anti-inflammatory activity; indeed, the margin between these activities may be greater than that observed with fenclofenac.…”
Section: Discussionsupporting
confidence: 93%
“…Indomethacin, like fenclofenac, markedly inhibits prostaglandin synthesis at doses lacking acute anti-inflammatory activity; indeed, the margin between these activities may be greater than that observed with fenclofenac. This finding supports recent demonstrations [6,22] that indomethacin, at doses producing little or no anticarrageenin oedema activity (i.e. ~< 1 mg/kg p.o.…”
Section: Discussionsupporting
confidence: 92%
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“…Recent work has demonstrated that at high (antirheumatic) concentrations NSAIDs inhibit neutrophil activation (13)(14)(15)(16)(17)(18)(19). We have previously shown that NSAIDs exerted a dosedependent inhibition of such activation induced by the chemoattractant fMet-Leu-Phe (13).…”
mentioning
confidence: 99%
“…The interaction between NSAIDs and PMNs is of interest, because an early sign of inflammation is usually an infiltration of the PMNs and many of the mechanisms possibly involved in the action of NSAIDs are related t o leucocytes (Walker et al 1976;Kaplan et al 1984). et a1 1989).…”
mentioning
confidence: 98%