Anti-inflammatory Effect of Angelicae Gigantis Radix Water Extract on LPS-stimulated Mouse Macrophages

Han, Hyo-Sang

doi:10.6116/kjh.2013.28.5.113

Cited by 8 publications

(5 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Herbal medicine can also reduce the incidence rates of deep vein thrombosis after lower extremity orthopedic surgery [ 49 ]. Angelicae Gigantis Radix, which was used most frequently in the RCTs, is known to demonstrate an anti-inflammatory effect by inhibiting proinflammatory mediators such as the tumor necrosis factor-alpha (TNF- α ), interleukin-6 (IL-6), IL-10, and vascular endothelial growth factor (VEGF) in lipopolysaccharide (LPS)-stimulated mouse macrophages [ 50 ]. The second most used components in herbal medicine were Paeoniae Radix, Achyranthis Radix, and Chaenomelis Fructus.…”

Section: Discussionmentioning

confidence: 99%

Traditional Chinese Medicine for Postoperative Care following Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-Analysis

Chang

Kim

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Objectives. This review verifies the clinical effects of traditional Chinese medicine (TCM) combined with conventional rehabilitation after anterior cruciate ligament reconstruction (ACLR). Methods. MEDLINE/PubMed, EMBASE, CENTRAL, JMAS, CNKI, and seven Korean databases were searched using predetermined strategies. The risk of bias was assessed using Cochrane Collaboration’s tool and a meta-analysis was conducted accordingly. Results. Nineteen randomized controlled trials involving 1283 participants were included in this systematic review and meta-analysis. The TCM treatment group showed more significant improvements in pain (MD −0.74, 95% CI [−0.93, −0.54]; I2 = 89%), range of motion (ROM) (SMD 1.19, 95% CI [0.78, 1.59]; I2 = 78%), and knee swelling (SMD −1.72, 95% CI [−2.38, −1.07]; I2 = 76%). The Lysholm score of the TCM treatment group significantly improved (MD 5.62, 95% CI [3.93, 7.32]; I2 = 84%) relative to the control group. The IKDC subjective score (MD 3.40, 95% CI [−0.61, 7.41]; I2 = 97%) and the hospital for special surgery (HSS) score did not improve initially (MD 6.79, 95% CI [−1.27, 14.86]; I2 = 97%) but did so during the subgroup analysis. TCM showed a long-term effect on the IKDC subjective score (MD −0.51, 95% CI [−1.69, 0.67]; I2 = 30%). A longer treatment period of 12 weeks showed more improvement (MD 5.96, 95% CI [0.69, 11.22]; I2 95%). Conclusion. TCM can be used as an adjuvant therapy to conventional rehabilitation for relieving pain, improving ROM and oedema, and facilitating better function of the knee joint after ACLR. However, this recommendation should be cautiously applied in clinical practice owing to the low quality of the included studies.

show abstract

Section: Discussionmentioning

confidence: 99%

Traditional Chinese Medicine for Postoperative Care following Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-Analysis

Chang

Kim

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…MIP-1 is best known for its chemotactic and proinflammatory effects but can also promote hematopoiesis. Particularly, MIP-1 β is expressed by T cells, B cells, and monocytes after antigen or mitogen stimulation [ 31 , 32 ]. SL treatment at 25, 50, and 100 μ g/mL suppressed significantly the MIP-1 α , the MIP-1 β , and the MIP-2 production in RAW 264.7 cells stimulated by LPS ( Table 1 ).…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Effect of Combination of Scutellariae Radix and Liriopis Tuber Water Extract

Choi

2015

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Scutellariae Radix and Liriopis Tuber have been used to treat the inflammatory diseases in traditional Korean medicine and anti-inflammatory effect of each herb has been shown partially in several articles. However, the combined extract of these medicinal herbs (SL) has not been reported for its anti-inflammatory effects. In this study, we investigated the effects of SL on the creation of several proinflammatory mediators in RAW 264.7 cell mouse macrophages induced by Lipopolysaccharide (LPS). SL inhibited significantly the increase of NO, the release of intracellular calcium, the increase of interleukin-6 (IL-6), macrophage inflammatory proteins (MIP-1α, MIP-1β, and MIP-2), and granulocyte colony-stimulating factor (G-CSF) in LPS-induced RAW 264.7 cell at the concentrations of 25, 50, and 100 μg/mL, and SL inhibited significantly the increase of macrophage colony-stimulating factor (M-CSF) at the concentrations of 25 and 50 μg/mL, and tumor necrosis factor (TNF) at the concentration of 25 μg/mL. These results implicate that SL has anti-inflammatory effects by suppressing the production of various inflammatory mediators in macrophages. But SL did not inhibit significantly the increase of granulocyte macrophage colony-stimulating factor (GM-CSF), leukemia inhibitory factor (LIF), and Regulated on Activation, Normal T cell Expressed and Secreted (RANTES); therefore, further study is demanded for the follow-up research to find out the possibility of SL as a preventive and therapeutic medicine for various inflammatory diseases.

show abstract

“…The TNF-α secretion rates of single-pigment bacteriochlorophyll a concentrations decreased in a concentration-dependent manner, and a secretion rate of 63.8% was identified at the highest concentration, indicating effects close to those of dexamethasone (positive control). When the abovementioned results were compared with those of previous studies on Angelica gigas water extracts that reported TNF-α reduction effects, the superiority of the TNF-α reduction effects of photosynthetic bacteria and bacteriochlorophyll a was identified, because the lowest secretion rate was greater than 85% in the case of Angelica gigas water extracts [8]. Because TNF-α increases the generation of MMP-1, an enzyme that hinders collagen generation [2,21], bacteriochlorophyll a that can reduce TNF-α is expected to be capable of reducing enzymes that hinder collagen generation, thereby showing efficacy for skin wrinkle improvement.…”

Section: Production Of Procollagen and Tnf-α From Human Skin Fibrobla...mentioning

confidence: 91%

Skin Anti-Aging Activities of Bacteriochlorophyll a from Photosynthetic Bacteria, Rhodobacter sphaeroides

Kim¹,

Yim

Lee³

2015

Journal of Microbiology and Biotechnology

View full text Add to dashboard Cite

In this work, the anti-aging skin effects of bacteriochlorophyll a isolated from Rhodobacter sphaeroides are first reported, with notably low cytotoxicity in the range of 1% to 14% in adding 0.00078 (% (w/w)) of the extracts, compared with the normal growth of both human dermal fibroblast and keratinocyte cells without any treatment as a control. The highest production of procollagen from human fibroblast cells (CCD-986sk) was observed as 221.7 ng/ml with 0.001 (% (w/w)) of bacteriochlorophyll a, whereas 150 and 200 ng/ml of procollagen production resulted from addition of 0.001 (% (w/w)) of the photosynthetic bacteria. The bacteriochlorophylla- induced TNF-α production increased to 63.8%, which was lower secretion from HaCaT cells than that from addition of 0.00005 (% (w/w)) of bacteriochlorophyll a. Additionally, bacteriochlorophyll a upregulated the expression of genes related to skin anti-aging (i.e., keratin 10, involucrin, transglutaminase-1, and MMPs), by up to 4-15 times those of the control. However, crude extracts from R. sphaeroides did not enhance the expression level of these genes. Bacteriochlorophyll a showed higher antioxidant activity of 63.8% in DPPH free radical scavenging than those of water, ethanol, and 70% ethanol extracts (14.0%, 57.2%, and 12.6%, respectively). It was also shown that the high antioxidant activity could be attributed to the skin anti-aging effect of bacteriochlorophyll a, although R. sphaeroides itself would not exhibit significant anti-aging activities.

show abstract

Anti-inflammatory Effect of Angelicae Gigantis Radix Water Extract on LPS-stimulated Mouse Macrophages

Cited by 8 publications

References 23 publications

Traditional Chinese Medicine for Postoperative Care following Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-Analysis

Traditional Chinese Medicine for Postoperative Care following Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-Analysis

Anti-Inflammatory Effect of Combination of Scutellariae Radix and Liriopis Tuber Water Extract

Skin Anti-Aging Activities of Bacteriochlorophyll a from Photosynthetic Bacteria, Rhodobacter sphaeroides

Contact Info

Product

Resources

About