Anti‑inflammatory effect of Chandrashura (Lepidium sativum Linn.) an experimental study

Raval, Nita D; Ravishankar, B; Ashok, B K

doi:10.4103/0974-8520.123132

Cited by 22 publications

(15 citation statements)

References 2 publications

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“…The extract dose dependently attenuated CCl 4 induced rise in serum levels of AST, ALT, APT, and bilirubin suggesting its hepatoprotective activity [ 196 ]. Recently L. sativum has been shown to possess significant antioxidant [ 197 – 199 ] and anti-inflammatory [ 200 ] activities which may contribute to its hepatoprotective effect. In rats, up to 2% w/w of L. sativum in diet did not produce any toxicity, whereas 10% w/w showed mild toxicity [ 201 ].…”

Section: Resultsmentioning

confidence: 99%

A Review of Hepatoprotective Plants Used in Saudi Traditional Medicine

Alasmari

Al-Elaiwi

Athar

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Liver disease is one of the major causes of morbidity and mortality across the world. According to WHO estimates, about 500 million people are living with chronic hepatitis infections resulting in the death of over one million people annually. Medicinal plants serve as a vital source of potentially useful new compounds for the development of effective therapy to combat liver problems. Moreover herbal products have the advantage of better affordability and acceptability, better compatibility with the human body, and minimal side effects and is easier to store. In this review attempt has been made to summarize the scientific data published on hepatoprotective plants used in Saudi Arabian traditional medicine. The information includes medicinal uses of the plants, distribution in Saudi Arabia, ethnopharmacological profile, possible mechanism of action, chemical constituents, and toxicity data. Comprehensive scientific studies on safety and efficacy of these plants can revitalise the treatment of liver diseases.

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Section: Resultsmentioning

confidence: 99%

A Review of Hepatoprotective Plants Used in Saudi Traditional Medicine

Alasmari

Al-Elaiwi

Athar

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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“…Chemically, the seeds of L. sativum contain essential oils, fatty oils, carbohydrate, protein, fatty acids, vitamins, flavonoids and isothiocynates glycoside [4] . Experimental evidences showed that L. sativum has antihypertensive [5] , diuretic [6] , anti-asthmatic [7] , hypoglycaemic [8] , antioxidant [4] , [9] , [10] and anti-inflammatory [11] properties.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Lepidium sativum against carbon tetra chloride induced hepatotoxicity and determination of its bioactive compounds by GC⿿MS

et al. 2015

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Lepidium sativum seed (LSS) (family: Cruciferae) has been used in traditional medicine for the treatment of jaundice, liver problems, spleen diseases and gastrointestinal disorders. It was also reported to possess antihypertensive, diuretic, anti-asthmatic, antioxidant, and anti-inflammatory activities. Attempt has been made to study hepatoprotective potential of LSS available in Saudi Arabian Market. The aim of the present study was to determine the hepatoprotective effect of ethanolic extracts of LSS against carbon tetrachloride (CCl4) induced acute liver injury in rats. The bioactive compounds responsible for this activity have been analyzed by GC⿿MS.To evaluate the hepatoprotective activity, six groups (n = 6) of rats were taken. First group was control, second was toxic and other groups received oral test solutions: 100 mg/kg silymarin, or LSS (100, 200, and 400 mg/kg), once daily for 7 consecutive days, followed by hepatotoxicity induction with CCl4. Blood and liver tissues were collected for biochemical, antioxidant and microscopic analyses. The bioactive constituents present in the extract were analyzed by GC⿿MS. Results showed that pretreatment with LSS and silymarin significantly reduced the level of serum alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP) and bilirubin (BIL), which was increased significantly in toxic group treated with only CCl4. Histological analysis of liver tissues in groups pretreated with LSS and silymarin showed mild necrosis and inflammation of the hepatocytes compared to the toxic group. GC⿿MS analysis of LSS showed the presence of twelve major fatty acids including alpha-linolenic acid as a major constituent. These results indicated that LSS exerts enhance hepatoprotective activity that could be attributed towards its antioxidant activity, coupled together with the presence of anti-inflammatory compounds in LSS extract.

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“…The plant leaves and seeds have been used in traditional medicine. The plant is reported to have hypoglycemic, antihypertensive, diuretic (Jouad et al, 2001;Patel et al, 2009) hemagglutinating, fracture healing (Eddouks et al, 2005;Yadav et al, 2011), anti-inflammatory (Raval et al, 2013), hepatoprotective (Abuelgasim et al, 2008;Al-Asmari et al, 2015), antioxidant (Agarwal and Verma, 2011;Zia-Ul-Haq et al, 2012) and anti-carcinogenic activities .…”

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confidence: 96%

Evaluation of cardioprotective activity of Lepidium sativum seed powder in albino rats treated with 5-fluorouracil

Mohamed¹,

Safwat²

2016

Beni-Suef University Journal of Basic and Applied Sciences

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Available onlineA B S T R A C T 5-fluorouracil (5-FU) is a chemotherapeutic agent used for treatment of solid tumors.Cardiotoxicity is a major complication of 5-FU therapy. Therefore, the aim of the present study was to evaluate the possible cardioprotective potency of Lepidium sativum seed powder (LS) against 5-FU-induced cardiotoxicity and oxidative stress in albino rats. The rats were divided into three groups. Rats in the control group received saline daily for 8 days only.Rats in FU-treated group received saline orally for 8 days, then I.P. injected with 5-FU (150 mg\kg B.W) on the 5th day. Rats in LS-treated group were orally dosed with LS (550 mg\kg B.W\day) for 8 days, and on the 5th day rats were administrated with the same previous dose of 5-FU. 5-FU induced cardiotoxicity was assessed by a significant increase in serum concentrations of cTnI, CK-MB, lipid profile and a moderate elevation of cardiac MDA. 5-FU significantly decreased serum HDL-c and GSH concentration in cardiac homogenate. Its administration also resulted in the release of some inflammatory markers such as myeloperoxidase and Interleukin-1β (IL-1β). All 5-FU altered parameters were markedly ameliorated by LS pre-co-post-treatment. Results of the present study suggest that LS has a significant effect on the protection of the heart against 5-FU-induced cardiotoxicity through maintaining the antioxidant and anti-inflammatory activities.

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Anti‑inflammatory effect of Chandrashura (Lepidium sativum Linn.) an experimental study

Cited by 22 publications

References 2 publications

A Review of Hepatoprotective Plants Used in Saudi Traditional Medicine

A Review of Hepatoprotective Plants Used in Saudi Traditional Medicine

Efficacy of Lepidium sativum against carbon tetra chloride induced hepatotoxicity and determination of its bioactive compounds by GC⿿MS

Evaluation of cardioprotective activity of Lepidium sativum seed powder in albino rats treated with 5-fluorouracil

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