Anti-inflammatory effect of collagen tripeptide in atopic dermatitis

Hakuta, Amiko; Yamaguchi, Yukie; Okawa, Tomoko; Yamamoto, Shoko; Sakai, Yasuo; Aihara, Michiko

doi:10.1016/j.jdermsci.2017.09.002

Cited by 28 publications

(27 citation statements)

References 35 publications

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“…In 2017, Hakuta et al conducted a clinical study of seventeen patients with atopic dermatitis who were randomly assigned to receive a daily (for 12 weeks) 3.9 g of either collagen tripeptide or normal collagen peptides and each subject served as their own control [ 28 ]. When their keratinocytes were analyzed, several inflammatory biomarkers were reduced and, in the 13 subjects that completed the study, trans-epidermal water loss was significantly reduced, but the blood parameters were not improved in either treatment group [ 28 ].…”

Section: Collagenmentioning

confidence: 99%

“…In a simplified description, the stratum corneum component organization has two major units: bricks and mortar where corneocytes make up the brick portion of the stratum corneum wall. This is surrounded by a lipid mortar (intercellular “cement”) constituting approximately 20% of the stratum corneum volume that helps maintain the integrity of the tissue elements [ 28 ]. The major lipids that form the multi-lamellar barrier of the stratum corneum consists of 50% ceramides, 25% cholesterol, and about 15% fatty acids (by mass) [ 45 , 46 ].…”

Section: Ceramidesmentioning

confidence: 99%

“… Collagen fiber structure, absorption/metabolism and deposition into skin cells and dermal layers. It is generally thought that collagen (derived products) are hydrolyzed into amino acids in the gastrointestinal tract (GI) prior to being absorbed into the blood circulation, which are then deposited into the skin cells and/or utilized as building block components for extracellular matrix proteins produced by fibroblasts [ 25 , 26 , 27 , 28 ]. ALA = Alanine, HYP = Hydroxyproline, GLY = Glycine, PRO = Proline, and Ser = Serine.…”

Section: Figurementioning

confidence: 99%

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Enhancing Skin Health: By Oral Administration of Natural Compounds and Minerals with Implications to the Dermal Microbiome

Vollmer¹,

West²,

Lephart

2018

IJMS

102

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The history of cosmetics goes back to early Egyptian times for hygiene and health benefits while the history of topical applications that provide a medicinal treatment to combat dermal aging is relatively new. For example, the term cosmeceutical was first coined by Albert Kligman in 1984 to describe topical products that afford both cosmetic and therapeutic benefits. However, beauty comes from the inside. Therefore, for some time scientists have considered how nutrition reflects healthy skin and the aging process. The more recent link between nutrition and skin aging began in earnest around the year 2000 with the demonstrated increase in peer-reviewed scientific journal reports on this topic that included biochemical and molecular mechanisms of action. Thus, the application of: (a) topical administration from outside into the skin and (b) inside by oral consumption of nutritionals to the outer skin layers is now common place and many journal reports exhibit significant improvement for both on a variety of dermal parameters. Therefore, this review covers, where applicable, the history, chemical structure, and sources such as biological and biomedical properties in the skin along with animal and clinical data on the oral applications of: (a) collagen, (b) ceramide, (c) β-carotene, (d) astaxanthin, (e) coenzyme Q10, (f) colostrum, (g) zinc, and (h) selenium in their mode of action or function in improving dermal health by various quantified endpoints. Lastly, the importance of the human skin microbiome is briefly discussed in reference to the genomics, measurement, and factors influencing its expression and how it may alter the immune system, various dermal disorders, and potentially be involved in chemoprevention.

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Section: Collagenmentioning

confidence: 99%

Section: Ceramidesmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

See 1 more Smart Citation

Enhancing Skin Health: By Oral Administration of Natural Compounds and Minerals with Implications to the Dermal Microbiome

Vollmer¹,

West²,

Lephart

2018

IJMS

102

View full text Add to dashboard Cite

show abstract

“…The significant improvement in these factors (at Day 60) is therefore expected, thereby substantiating the effect of collagen peptide consumption on the skin's ECM. Pro‐Hyp and Hyp‐Gly have shown to increase skin hydration by ameliorating skin barrier dysfunction 50 and perhaps also by reducing inflammation 51 . Playing a key role in maintaining cell volume of epidermal keratinocytes, taurine in NCA may have helped maintain the improvement in skin hydration 20 …”

Section: Discussionmentioning

confidence: 99%

“…In connection with skin disorders, carotenoids can also scavenge peroxyl radicals at low oxygen tension, thereby preventing lipid peroxidation in skin 52,53 . Antioxidants and collagen peptides, both, may help reduce inflammation, and therefore be useful for inflammatory conditions of skin like atopic dermatitis as well 51,54,55 …”

Section: Discussionmentioning

confidence: 99%

Efficacy of a collagen hydrolysate and antioxidants‐containing nutraceutical on metrics of skin health in Indian women

Motwani¹,

Khan²,

Pai³

et al. 2020

J of Cosmetic Dermatology

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Background The skin’s aging process involves a decreased biosynthesis of extracellular matrix proteins (predominantly collagen) compounded by damage from environmental and intrinsic stressors. The Indian population is susceptible to skin damage given its geography and increasing urbanization or a genetic disposition. Previous studies have investigated nutrients such as collagen peptides, vitamins and phytonutrient‐rich botanical extracts for their individual benefits on skin. Aims This study examined the collective effect of a proprietary blend of these nutrients (in Nutrova Collagen+Antioxidants; NCA) on skin parameters, which has not been previously studied, especially in an Indian context. Patients/Methods 34 healthy, Indian women (mean age = 39.5 years) were given a placebo daily for 30 days to establish a baseline, followed by NCA for two intervals of 30 days. 3D image reconstruction allowed the analysis of skin topography and blemishes. Instrumental measurements also included skin firmness, elasticity, hydration, and transepidermal water loss. Clinical evaluation was used to grade blemishes, wrinkles and periorbital hyperpigmentation. Results Based on instrumental evaluation, NCA significantly reduced wrinkle width, open pores, skin roughness, and the colour of hyperpigmented blemishes, while improving skin hydration, firmness and barrier function from baseline to Day 30 and Day 60. NCA also increased elasticity at Day 30. Clinical evaluation showed that periorbital hyperpigmentation and wrinkles reduced significantly. Conclusion NCA is effective for improving overall skin health in Indian women. These results show that targeted nutrient supplementation can improve skin health and further research over extended durations is merited.

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Study on the molecular mechanism of atopic dermatitis in mice based on skin and serum metabolomic analysis

Wang,

Chen,

Liu

et al. 2024

Metabolomics

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Anti-inflammatory effect of collagen tripeptide in atopic dermatitis

Abstract: CTP may have therapeutic benefit for AD by inhibiting type 2-skewed allergic inflammation.

Cited by 28 publications

References 35 publications

Enhancing Skin Health: By Oral Administration of Natural Compounds and Minerals with Implications to the Dermal Microbiome

Enhancing Skin Health: By Oral Administration of Natural Compounds and Minerals with Implications to the Dermal Microbiome

Efficacy of a collagen hydrolysate and antioxidants‐containing nutraceutical on metrics of skin health in Indian women

Study on the molecular mechanism of atopic dermatitis in mice based on skin and serum metabolomic analysis

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