Anti-inflammatory Effect of Extracts from Folk Plants in Ulleung Island

Kim, Hyun-Jun; Lee, Dongjun; Ku, Ja-Jung; Choi, Kyung Ho; Park, Kwang-Woo; Kang, Shin-Ho; Moon, Chéol; Lee, Pyeongjae

doi:10.7732/kjpr.2013.26.2.169

Cited by 15 publications

(4 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The study of methanolic extracts of L . lancifolium bulbs, on NO inhibition, in LPS‐treated RAW 264.7 cells (Kim et al, 2013) showed 21.93 ± 4.68% of NO inhibition at a concentration of 50 µg/ml; thus, the effect on NO inhibition of bulbs of this study could be considered.…”

Section: Resultsmentioning

confidence: 63%

Antioxidant and anti‐inflammatory effects of Lilium lancifolium bulbs extract

et al. 2020

View full text Add to dashboard Cite

Lilium lancifolium is native to Northeast Asia and its bulbs have been used for medicinal treatment. Moreover, Japan has been using L. lancifolium bulbs more actively as food ingredients than Korea. Therefore, this study was to investigate the characteristics of Korean L. lancifolium bulbs, with respect to food component and functionality. As a result of proximate composition analysis, L. lancifolium bulbs have an abundant carbohydrate content. HPLC analysis indicated p‐coumaric acid and ferulic acid contents of Korean L. lancifolium extract were 1.14 ± 0.01, 1.46 ± 0.00 mg/g, but only p‐coumaric acid was less detected in Japanese extract. Also, Korean L. lancifolium bulbs extract exhibited significant antioxidant effects, as evaluated with antioxidant activity and compound, than Japanese extract. Furthermore, Korean L. lancifolium bulbs extract significantly inhibited pro‐inflammatory protein expressions through MyD88 dependent pathway. Therefore, these results suggested Korean L. lancifolium bulbs have the potential to being functional food ingredients. Practical applications Lilium lancifolium is a perennial plant belonging to the Liliaceae family. The storage organ of L. lancifolium is surrounded by several fleshy nodes at the base of the stem, called the bulb, which has been used as food or medicine to treat pneumonia and bronchitis. L. lancifolium is widely found in countries of Northeast Asia, such as Korea, Japan, and China, and its bulbs have been studied for presence of bioactive compounds that have important functional activities. The bioactive compounds in the L. lancifolium bulbs may vary from region to region. In this study, the difference observed in the contents of different bioactive compounds and the efficacy of anti‐inflammatory effects of L. lancifolium bulbs from different regions were consistent in this regard. As a comparative study of food materials by region, these L. lancifolium bulbs have the potential to be used as a food material for preventing inflammatory diseases.

show abstract

Section: Resultsmentioning

confidence: 63%

Antioxidant and anti‐inflammatory effects of Lilium lancifolium bulbs extract

et al. 2020

View full text Add to dashboard Cite

show abstract

“…위 약물들은 여드름 형성 억제를 위해 정도의 차이는 있지만 강력한 면포 용해 기능을 가지고 있고 여 드름 균의 증식을 억제하며 염증반응을 완화 시키는 효능이 있어 치료효과를 증진시킨다 . 그러나 이 약물들은 장기간 사용 했을 때 피부자극과 건조함, 홍조, 가려움의 부작용 (Kim & Lee, 2009;Suh et al, 2016 (Kim et al, 2013), 항산화와 항암효과가 나타났다 (Kim et al, 2010b).…”

Section: 최근에는 4가지 원인 외에 피부장벽 이상에 의하여 여드름이unclassified

Trends in the Efficacy and Safety of Ingredients in Acne Skin Treatments

Lee¹,

Son²

2018

Asian J Beauty Cosmetol

View full text Add to dashboard Cite

The aim of this study is to explore trends in safety and efficacy of ingredients used in treatments for acne at a time when the distrust of chemicals is growing. 'Acne' is a chronic inflammatory follicular disorder of the skin. Propionibacterium acnes (P. acnes) plays critical roles in the outbreak of acne by inducing inflammation and forming comedones. Currently, the main methods of treatment for acne vulgaris include oral antibiotics, anti-inflammatory drugs, retinoids, and topical medication. However, prolonged use of these drugs can cause side effects such as skin irritation, dryness, flushing, itching, and resistance to the drug. Thus, there is a demand for effective natural alternatives. Natural extracts that reduce bacterial activity to treat acne are expected to have significantly fewer side effects than existing medications. According to studies anti-bacterial effects are such as Nelumbo nucifera G., Corni fructus , Persicaria perfoliata , Taraxacum mongolicum H., Phragmitis rhizoma , Agrimonia pilosa , Lavandula offcinalis , Cymbopogon martini , Menthapiperita , Eucalyptus globulus, Camellia japonica, ceramide, propolis, epidermal growth factor (EGF) and so on. Further tests of the safety and efficacy of natural extracts with antibacterial properties compared to existing acne medications are needed.

show abstract

“…The increase in dietary antioxidant intakes may help to support the limiting antioxidant concentrate and also promote the normal functioning of physiological systems [ 20 ]. The potential of the extracts from indigenous Korean plants to scavenge these free radicals and modulate inflammatory reactions has been demonstrated [ 21 , 22 , 23 ]. Additionally, many researchers have used the antioxidant activity assay to reveal the beneficial effect of different plant extracts [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Nontargeted Metabolomics as a Screening Tool for Estimating Bioactive Metabolites in the Extracts of 50 Indigenous Korean Plants

et al. 2021

View full text Add to dashboard Cite

Many indigenous Korean plants have been used in medicinal preparations and health-promoting foods. These plant species contain beneficial metabolites with various bioactivities, such as antioxidant and anti-inflammatory activities. Herein, we suggest a new screening strategy using metabolomics to explore the bioactive compounds in 50 Korean plants. Secondary metabolites were analyzed using UHPLC-LTQ-Orbitrap-MS/MS. The plant extracts were subjected to antioxidant and anti-inflammatory assays. We identified metabolites that contributed to bioactivities according to the results of bioassays and multivariate analyses. Using Pearson’s correlation, phenolics (e.g., casuarictin, 3-O-methylellagic acid) showed positive correlation with antioxidant activity, while biflavonoids (e.g., amentoflavone, rosbustaflavone) were correlated with nitric oxide (NO) inhibition activity. To compensate for the limitation of this new strategy, we further validated these by investigating three parts (branches, fruits, leaves) of Platycladus orientalis which showed high activities on both bioassays. Unlike the above observation, we identified significantly different metabolites from different parts, which was not the results of bioassays. In these validation steps, interestingly, biflavonoids (e.g., robustaflavone, sciadopitysin) contributed to both activities in P. orientalis. The findings of this work suggest that new strategy could be more beneficial in the identification of bioactive plant species as well as that of their corresponding bioactive compounds that impart the bioactivity.

show abstract

Anti-inflammatory Effect of Extracts from Folk Plants in Ulleung Island

Cited by 15 publications

References 23 publications

Antioxidant and anti‐inflammatory effects of Lilium lancifolium bulbs extract

Antioxidant and anti‐inflammatory effects of Lilium lancifolium bulbs extract

Trends in the Efficacy and Safety of Ingredients in Acne Skin Treatments

Nontargeted Metabolomics as a Screening Tool for Estimating Bioactive Metabolites in the Extracts of 50 Indigenous Korean Plants

Contact Info

Product

Resources

About