Trends in the Efficacy and Safety of Ingredients in Acne Skin Treatments

Abstract

The aim of this study is to explore trends in safety and efficacy of ingredients used in treatments for acne at a time when the distrust of chemicals is growing. 'Acne' is a chronic inflammatory follicular disorder of the skin. Propionibacterium acnes (P. acnes) plays critical roles in the outbreak of acne by inducing inflammation and forming comedones. Currently, the main methods of treatment for acne vulgaris include oral antibiotics, anti-inflammatory drugs, retinoids, and topical medication. However, prolonged use of these drugs can cause side effects such as skin irritation, dryness, flushing, itching, and resistance to the drug. Thus, there is a demand for effective natural alternatives. Natural extracts that reduce bacterial activity to treat acne are expected to have significantly fewer side effects than existing medications. According to studies anti-bacterial effects are such as Nelumbo nucifera G., Corni fructus , Persicaria perfoliata , Taraxacum mongolicum H., Phragmitis rhizoma , Agrimonia pilosa , Lavandula offcinalis , Cymbopogon martini , Menthapiperita , Eucalyptus globulus, Camellia japonica, ceramide, propolis, epidermal growth factor (EGF) and so on. Further tests of the safety and efficacy of natural extracts with antibacterial properties compared to existing acne medications are needed.

Antioxidant and Antibacterial Effects of Mixed Extracts of Phyllanthus emblica, Geranium (Pelargonium graveolens) and Commiphora myrrha: Possibility of Natural Materials for Acne Treatment

“…As a result of the analysis of antibacterial activity against P. acnes, which is the causative agent of acne, in this study, PGC-4 was found to have the highest antibacterial effect, and the antibacterial effect of PGC-3 was found to be higher than that of PGC-1 and PGC-2 although it was lower than that of PGC-4. The natural physiologically active ingredients mainly contained in plants can be divided into four types: alkaloids, terpenes, flavonoids, and phenols [37]. In particular, Geranium (P. graveolens) and C. myrrha, which are natural plants, contain various physiologically active compounds such as phenolic compounds.…”

Effects of Oil/Moisture Changes after Using Herbal Peeling Therapy on Women in their 20s and 30s with Comedonal Acne Skin

“…필 링은 피부침투 영역에 따라 약간의 차이가 있지만 콜라겐 합성을 촉 진하여 탄력, 주름 개선 효과와 여드름 개선 등을 목적으로 시행되 고, 대부분 색소성 피부의 미백작용에 효과가 보고되었다 (Lee et al, 2005). 여드름의 경우 연령에 상관없이 외부환경적 요인이나 스 트레스로 인해 흔히 발생하고 (Lee & Son, 2018), 심리적으로도 여 러 가지 복합적인 영형을 끼친다 (Lee & Choi, 2019 (Kong & Hwang, 2010), 약초 성분의 미립자로 인해 미네랄 성 분의 흡수율을 높여 피부의 노폐물을 제거해주는 특징이 있다 (Han & Kim, 2014…”

A Systematic Review of the Functional Ingredients and Physiological Activities of Taraxacum coreanum Nakai

“…(Baek & Lee, 2011), 근래의 연구에서도 꽃, 잎, 뿌리의 열 수 추출물 모두 농도 의존적으로 항암 활성을 나타내며 (Park et al, 2015), 민들레에서 분리한 luteolin을 대상으로 aldose reductase 저 해 활성을 측정한 결과 α-glucosidase 저해 활성이 우수하게 나타났 다 (Park et al, 2002). Lee & Son (2017) (You et al, 2010).…”