Anti-inflammatory effect of l-cysteine (a semi-essential amino acid) on 5-FU-induced oral mucositis in hamsters

Fonseca, Khetyma Moreira; RodriguesCosta, Dionys Macda; Silva, Valderlon Freitas da; Carvalho, Jelson Lina de; Oliveira, Ana Patrícia de; Sousa, Francisca Beatriz de Melo; Lopes, André Luís Fernandes; Martins, Conceição da Silva; Chaves, Letícia de Sousa; Nicolau, Lucas Antônio Duarte; Cerqueira, Gilberto Santos; Medeiros, Jand Venes Rolim

doi:10.1007/s00726-021-03062-z

Cited by 14 publications

(3 citation statements)

References 56 publications

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“…In-depth study: cysteine metabolism and immunity in AA Cysteine and its metabolic products are increasingly recognized for its potential role in reducing inflammation and modulating immune responses, which are central to the pathogenesis of various autoimmune disorders (Zeinali et al 2018;Yu et al 2021;Geng et al 2023). Supplementation with cysteine alleviates conditions such as mucositis and significantly reduces oxidative stress and systemic inflammation in elderly individuals, suggesting its potential therapeutic benefits in AA (Kumar et al 2021;Fonseca et al 2021). S-propenyl cysteine, a derivative, can inhibit the NF-κB pathway and activate the Keap1/Nrf2 pathway, mitigating inflammation and oxidative stress, thereby supporting cysteine's role in managing autoimmune disorders (Mo et al 2020).…”

Section: Interplay Analysis: Cysteine Metabolism Autophagy and Aamentioning

confidence: 99%

Dissecting hair breakage in alopecia areata: the central role of dysregulated cysteine homeostasis

Xu,

Xie,

Wei

et al. 2024

Amino Acids

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In the initial stages of Alopecia Areata (AA), the predominance of hair breakage or exclamation mark hairs serves as vital indicators of disease activity. These signs are non-invasive and are commonly employed in dermatoscopic examinations. Despite their clinical salience, the underlying etiology precipitating this hair breakage remains largely uncharted territory. Our exhaustive review of the existing literature points to a pivotal role for cysteine—a key amino acid central to hair growth—in these mechanisms. This review will probe and deliberate upon the implications of aberrant cysteine metabolism in the pathogenesis of AA. It will examine the potential intersections of cysteine metabolism with autophagy, ferroptosis, immunity, and psychiatric manifestations associated with AA. Such exploration could illuminate new facets of the disease's pathophysiology, potentially paving the way for innovative therapeutic strategies.

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Section: Interplay Analysis: Cysteine Metabolism Autophagy and Aamentioning

confidence: 99%

Dissecting hair breakage in alopecia areata: the central role of dysregulated cysteine homeostasis

Xu,

Xie,

Wei

et al. 2024

Amino Acids

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“…L-cysteine is one kind of the semi-essential amino acids, widely participates in activities in living organisms. L-cysteine is characterized by the presence of a 3 sulfhydryl group in its structure, which allows it to participate in the reduction process of cells and protect cells from toxic substances [1,2]. Normal physiological activities in living organisms are inseparable from a stable environment, which requires a stable concentration of L-cysteine in the environment.…”

Section: Introductionmentioning

confidence: 99%

Lentinan stabilized bimetallic PdPt3 dendritic nanoparticles with enhanced oxidase-like property for L-cysteine detection

Dong

Zhang

et al. 2022

International Journal of Biological Macromolecules

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“…26 The thiol group of cysteine can resist free radical attacks, protect cells from oxidative damage, and exert anti-inflammatory effects. [27][28][29] Oral cysteine supplementation promotes corneal cell growth, facilitating rapid repair of corneal damage after eye surgery. 30 Glutamine deficiency in the cornea leads to the degeneration of corneal endothelial cells.…”

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confidence: 99%

Nutrient Supplementation Improves Contact Lens–Induced Corneal Cell Damage Based on a SIRC Cellular Model

Chang

Tsai

Liu

et al. 2023

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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Objectives: The long-term use of contact lenses may damage the structure of the ocular surface and cause metabolic disorders in corneal cells. Vitamins and amino acids help maintain the physiological function of the eye. In the present study, the effects of nutrient (vitamin and amino acid) supplementation on corneal cell repair after contact lens–induced damage was investigated. Methods: High-performance liquid chromatography was used to quantify the nutrient contents of minimum essential medium, and the MTT assay was used to measure the viability of corneal cells. A Statens Seruminstitut rabbit cornea cellular model was established to simulate contact lens–induced keratopathy and investigate the effects of vitamin and amino acid supplementations on corneal cell repair. Results: The high water content lens group (78%) has a cell viability as high as 83.3%, whereas the cell viability of the low water content lens group (38%) is only 51.6%. The 32.0% difference between the two groups confirms the correlation between water content of lens and corneal viability. Conclusions: Vitamin B2, vitamin B12, asparagine, and taurine supplementation may help improve contact lens–induced damage.

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Anti-inflammatory effect of l-cysteine (a semi-essential amino acid) on 5-FU-induced oral mucositis in hamsters

Cited by 14 publications

References 56 publications

Dissecting hair breakage in alopecia areata: the central role of dysregulated cysteine homeostasis

Dissecting hair breakage in alopecia areata: the central role of dysregulated cysteine homeostasis

Lentinan stabilized bimetallic PdPt3 dendritic nanoparticles with enhanced oxidase-like property for L-cysteine detection

Nutrient Supplementation Improves Contact Lens–Induced Corneal Cell Damage Based on a SIRC Cellular Model

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