Anti-inflammatory effect of lycopene on endotoxin-induced uveitis in rats

Physicochemical characterization, the Hirshfeld surface, and biological evaluation of two meloxicam compounding pharmacy samples

“…The carrageenan injection induced a marked and long-lasting paw edema that was already evident at 2 h after injection. Dexamethasone 10 mg/kg resulted in the strongest anti-edematogenic effect ( P < 0.001), as expected, because it is a steroidal anti-inflammatory agent that acts in the early stages of the inflammatory process; this drug is often used as a positive control in comparative studies [16] , [17] , [18] , [19] . Nevertheless, owing to the side effects observed in the medicinal uses of this class of materials, it is necessary to obtain effective drugs that result in fewer adverse events.…”

“…In contrast, the overall interactions calculated for form III, were present in (de × di), as low as 1.0 Å and rose to over 2.8 Å ( Fig. 9 ; form III) [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] . The observed turn around the thiazole ring in polymorph III increased the amount of interactions that contributed to different dissolution behavior.…”

“…To study the effects of the two meloxicam samples on the carrageenan-induced paw edema, the positive control of dexamethasone 10 mg/kg, which is frequently used in preclinical assays [16] , [17] , [18] , [19] , was used, and resulted in the highest anti-edematogenic activity, as expected. This steroidal anti-inflammatory drug markedly inhibits the early stages of the inflammatory process, but may also induce many side effects.…”

“…Nevertheless, owing to the side effects observed in the medicinal uses of this class of materials, it is necessary to obtain effective drugs that result in fewer adverse events. At present, the oxicams play an important role as anti-inflammatory agents [19] , [20] .…”

Effects of Post-Treatment Hydrogen Gas Inhalation on Uveitis Induced by Endotoxin in Rats

“…Endotoxin-induced uveitis (EIU) is a widely used animal model to mimic the pathological features and investigate potential treatments for human uveitis [ 6 ]. Its pathogenesis was deemed to be closely associated with OS [ 7 , 8 ], and drugs that can mitigate OS have been shown to ameliorate EIU [ 9 , 10 ].…”