2018
DOI: 10.12659/msm.907269
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Effects of Post-Treatment Hydrogen Gas Inhalation on Uveitis Induced by Endotoxin in Rats

Abstract: BackgroundMolecular hydrogen (H2) has been widely reported to have benefiicial effects in diverse animal models and human disease through reduction of oxidative stress and inflammation. The aim of this study was to investigate whether hydrogen gas could ameliorate endotoxin-induced uveitis (EIU) in rats.Material/MethodsMale Sprague-Dawley rats were divided into a normal group, a model group, a nitrogen-oxygen (N-O) group, and a hydrogen-oxygen (H-O) group. EIU was induced in rats of the latter 3 groups by inje… Show more

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Cited by 10 publications
(11 citation statements)
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“…H 2 can improve various pathological conditions by regulating the expression of various proteins, which include: matrix metalloproteinase, brain natriuretic peptide, intercellular adhesion molecule-1, myeloperoxidase, cyclooxygenase-2, neuronal nitric oxide synthase, manganese superoxide dismutase, collagen III, ionized calcium binding adapter molecule 1. 73 74 These molecules may not be the main target molecules of H 2 , but their indirect function can affect the termination effect, which can be analyzed at the gene and protein level to find molecular targets for H 2 to prevent and treat diseases.…”
Section: Olecular M Echanism Of H ...mentioning
confidence: 99%
“…H 2 can improve various pathological conditions by regulating the expression of various proteins, which include: matrix metalloproteinase, brain natriuretic peptide, intercellular adhesion molecule-1, myeloperoxidase, cyclooxygenase-2, neuronal nitric oxide synthase, manganese superoxide dismutase, collagen III, ionized calcium binding adapter molecule 1. 73 74 These molecules may not be the main target molecules of H 2 , but their indirect function can affect the termination effect, which can be analyzed at the gene and protein level to find molecular targets for H 2 to prevent and treat diseases.…”
Section: Olecular M Echanism Of H ...mentioning
confidence: 99%
“…Hydrogen treatment can inhibit microglial inflammation by increasing Nrf2 expression and then inhibiting LPS-induced expression of NLRP3, caspase-1 and multiple cytokines including IL-1β and IL-18 [107,108]. The activation state of microglia in EIU rats could be somewhat mitigated by hydrogen gas, but the exact mechanism in this process remains obscure [109]. During EAU, activating the aryl hydrocarbon receptor (AhR) via TCDD treatment inhibited microglial activation, reduced retinal cell apoptosis and downregulated proinflammatory cytokines, including TNF-α, IL-6 and IL-1β, thus exhibiting an immunomodulatory effect [110].…”
Section: Uveitismentioning
confidence: 99%
“…With the support of hydrogen inhaler AMS-H-01/AMS-H-03 provided by Asclepius Meditec Co., Ltd., tens of animal studies or pilot clinical trials based on inhaled gas which combines H 2 (concentration of ~66%) with O 2 (concentration of ~34%) were accomplished and published. 14 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 Additionally, recent formal clinic trials based on the same inhaler AMS-H-01/AMS-H-03 also revealed positive results in respiratory diseases, such as allergic rhinitis, asthma, chronic obstructive pulmonary disease, etc. Especially, it is recommended to use the mixed gas of 66.6% H 2 /33.3% O 2 for treating coronavirus disease-19 (COVID-19) patients as described in the Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia, 7 Edition released by National Health Commission of China, 55 and such guideline is also republished in English by the World Health Organization China Office.…”
Section: Introduction Of H Ydrogen B Iomedicinementioning
confidence: 99%