Anti-inflammatory effect of sophoraflavanone G isolated from Sophora flavescens in lipopolysaccharide-stimulated mouse macrophages

Wun, Zih-Yi; Lin, Chwan-Fwu; Huang, Wen‐Chung; Huang, Yu‐Ling; Xu, Pei-Yin; Chang, Wei‐Tien; Wu, Sibin; Liou, Chian-Jiun

doi:10.1016/j.fct.2013.08.072

Cited by 32 publications

(30 citation statements)

References 36 publications

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“…Lycopene also suppresses NO and IL-6 production by blocking the activation of MAPK and NF-jB pathways in macrophages [32]. We previously found that sophoraflavanone G isolated from Sophora flavescens could suppress COX-2 and iNOS expression in LPS-stimulated macrophages [9]. In the present study, sesamol significantly reduced iNOS and NO production and also inhibited COX-2 and PGE 2 expression.…”

Section: Discussionsupporting

confidence: 49%

“…The effects of sesamol on cell viability were determined with the 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, as previously described [9]. In brief, the cells (5 9 10 3 cells/well) were seeded in 96-well plates and treated with sesamol for 24 h. Then, cells were treated with 5 mg/ml MTT solution for 4 h at 37°C.…”

Section: Cell Viability Assaymentioning

confidence: 99%

“…The mitogen-activated protein kinase (MAPK) signaling pathway also plays an important role in upregulating inflammatory gene expression in LPS-stimulated macrophages [8]. Several studies found that phosphorylation of MAPKs could induce NF-jB activation and regulate inflammatory gene expression [7,9]. Hence, suppressing NF-jB and MAPK pathways could ameliorate the inflammatory response.…”

Section: Introductionmentioning

confidence: 99%

“…A recent study discovered that some natural products could ameliorate antioxidant responses and the inflammatory response in LPS-stimulated macrophages [9,15,16]. Sesamun indicum, Linn.…”

Section: Introductionmentioning

confidence: 99%

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Sesamol suppresses the inflammatory response by inhibiting NF-κB/MAPK activation and upregulating AMP kinase signaling in RAW 264.7 macrophages

Liou

et al. 2015

Inflamm. Res.

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Section: Discussionsupporting

confidence: 49%

Section: Cell Viability Assaymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…A recent study discovered that some natural products could ameliorate antioxidant responses and the inflammatory response in LPS-stimulated macrophages [9,15,16]. Sesamun indicum, Linn.…”

Section: Introductionmentioning

confidence: 99%

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Sesamol suppresses the inflammatory response by inhibiting NF-κB/MAPK activation and upregulating AMP kinase signaling in RAW 264.7 macrophages

Liou

et al. 2015

Inflamm. Res.

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“…Arylbenzofurans and flavonoids isolated from the rhizomes and roots of S. tonkinensis showed IL-6 production inhibitory activity [32]. Antiinflammatory action of sophoraflavanone G isolated from S. flavescens in lipopolysaccharide-stimulated mouse macrophages [33]. It has an antiinflammatory property, reduced proinflammatory cytokines production via obstruction of the NF-κB and MAPK transmission.…”

Section: Discussionmentioning

confidence: 99%

Bioinformatics: Inflammatory Cytokines and Attenuation of Diabetes Hypercholesterolemia-Induced Renal Injury Using Morning Glory and Necklace Pod Extracts

Aly

Abd‐Alla²,

Ali³

et al. 2017

Asian J Pharm Clin Res

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Objective: The present research in bioinformatics focuses on pharmacological effects of morning glory and necklace pod ethanolic extracts (MGE and NPE) on some biochemical parameters in high fat diet-induced hypercholesterolemia and streptozotocin-induced hyperglycemia in rats.Methods: Compared to atorvastatin; an anti-hypercholesterolemic (HC) and glibenclamide; an antidiabetic drug. Endothelium activation markers of soluble vascular cell adhesion molecule (VCAM)-1 and intercellular adhesion molecule (ICAM)-1 were determined using enzyme-linked immunosorbent assay. Creatinine, urea, and inflammatory biomarkers; C-reactive protein (CRP) and pro-inflammatory cytokines including tumor necrosis factor alpha (TNF-α) and interleukin (IL)-10 levels were also measured in serum of different therapeutic groups.Results: Significant decrease in ICAM-1 level with MGE and NPE supplemented to normal rats as compared to untreated control with percentages decrease 17.80 and 12.00% was observed. Insignificant change was detected in VCAM-1 level. Profound amelioration in CRP, total urea and creatinine levels by NPE treatment. Creatinine, urea, CRP, and TNF-α level were significantly increased in hyperglycemic (HG)-HC rats. However, IL-10 level showed a significant decrease. Meanwhile, histopathological investigation of the kidney and heart was carried out. Image recognition system for kidney and heart images was developed to diagnose their diseases. Tested extract attenuated creatinine, urea, CRP, and TNF-α level. Hyperglycemia and hypercholesterolemia linked kidney disorders were relieved. Conclusion:In vivo oral administration with each extract declared suppression of cytokines mediated inflammation, vascular function leading to infiltration reduction of renal macrophage together with lowering in kidney indices and ameliorate renal tissues architectures in HG-HC rats.

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Sophoraflavanone G suppresses the progression of triple‐negative breast cancer via the inactivation of EGFR–PI3K–AKT signaling

Cheng

Liú

Guo

et al. 2022

Drug Development Research

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Sophoraflavanone G (SG), a prenylated flavonoid extracted from Sophora flavescens, has been found to possess antitumor activity in several types of human cancer. However, the biological functions and molecular mechanism of SG in triple‐negative breast cancer (TNBC) are required to be investigated. On the basis of network pharmacology methods and molecular docking technology, estimated glomerular filtration rate (EGFR) was identified as a potential target, and phosphatidylinositol 3‑kinase–protein kinase B (PI3K–AKT) signaling was demonstrated as an important signaling pathway for SG to treat breast cancer. TNBC cells (BT‐549 and MDA‐MB‐231) were used to determine the effects of SG in vitro. Cell Counting Kit, 5‐ethynyl‐2′‐deoxyuridine, and colony formation assays confirmed the proliferation inhibition of SG on TNBC cells. Moreover, SG administration promoted cell apoptosis by affecting Bax, Bcl‐2, and cleaved caspase‐3 expression. SG treatment also enhanced oxidative stress of TNBC cells by inducing reactive oxygen species production, increasing malondialdehyde (MDA) level, and decreasing superoxide dismutase activity. Additionally, SG suppressed cell migration, invasion, and epithelial–mesenchymal transition process. Inactivated EGFR–PI3K–AKT signaling was observed in TNBC cells after treatment with SG. Furthermore, the inhibitory effects of SG on cell proliferation and metastasis and the promotive effects of SG on cell apoptosis and oxidative stress were significantly attenuated due to the overexpression of EGFR. Mice experiments revealed the suppression of SG on tumor growth and EGFR–PI3K–AKT signaling. Together, SG repressed the proliferation and metastasis, and induced apoptosis and oxidative stress in TNBC by targeting the EGFR–PI3K–AKT signaling pathway. SG might serve as a promising therapeutic agent to combat TNBC.

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Anti-inflammatory effect of sophoraflavanone G isolated from Sophora flavescens in lipopolysaccharide-stimulated mouse macrophages

Cited by 32 publications

References 36 publications

Sesamol suppresses the inflammatory response by inhibiting NF-κB/MAPK activation and upregulating AMP kinase signaling in RAW 264.7 macrophages

Sesamol suppresses the inflammatory response by inhibiting NF-κB/MAPK activation and upregulating AMP kinase signaling in RAW 264.7 macrophages

Bioinformatics: Inflammatory Cytokines and Attenuation of Diabetes Hypercholesterolemia-Induced Renal Injury Using Morning Glory and Necklace Pod Extracts

Sophoraflavanone G suppresses the progression of triple‐negative breast cancer via the inactivation of EGFR–PI3K–AKT signaling

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