Anti-inflammatory effect of sugar-amino acid Maillard reaction products on intestinal inflammation model in vitro and in vivo

Oh, Jun Gu; Chun, Su Hyun; Kim, Da Hyun; Kim, Jin Hye; Shin, Hye Soo; Cho, Yong Soo; Kim, Yong Ki; Choi, Hee Don; Lee, Kwang Won

doi:10.1016/j.carres.2017.07.003

Cited by 23 publications

(16 citation statements)

References 37 publications

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“…Inflammatory cells, such as macrophages, play important pathogenic roles in the inflammatory responses in the intestine as well as intestinal epithelial cells . Therefore, THP-1 cells, a monocyte-derived macrophage-like cell type, are commonly used for cellular studies on the pro-inflammatory effects of nanomaterials . While TiO 2 and SiO 2 NPs increased the levels of ROS in THP-1 macrophages in the present study, they had no cytotoxic effects on these macrophages.…”

Section: Discussionmentioning

confidence: 45%

Functionalized Surface-Charged SiO₂ Nanoparticles Induce Pro-Inflammatory Responses, but Are Not Lethal to Caco-2 Cells

Tada‐Oikawa

Eguchi

Yasuda

et al. 2020

Chem. Res. Toxicol.

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Nanoparticles (NPs) are widely used in food, and analysis of their potential gastrointestinal toxicity is necessary. The present study was designed to determine the effects of silica dioxide (SiO 2 ), titanium dioxide (TiO 2 ), and zinc oxide (ZnO) NPs on cultured THP-1 monocyte-derived macrophages and human epithelial colorectal adenocarcinoma (Caco-2) cells. Exposure to ZnO NPs for 24 h increased the production of redox response species (ROS) and reduced cell viability in a dose-dependent manner in THP-1 macrophages and Caco-2 cells. Although TiO 2 and SiO 2 NPs induced oxidative stress, they showed no apparent cytotoxicity against both cell types. The effects of functionalized SiO 2 NPs on undifferentiated and differentiated Caco-2 cells were investigated using fluorescently labeled SiO 2 NPs with neutral, positive, or negative surface charge. Exposure of both types of cells to the three kinds of SiO 2 NPs significantly increased their interaction in a dose-dependent manner. The largest interaction with both types of cells was noted with exposure to more negatively surface-charged SiO 2 NPs. Exposure to either positively or negatively, but not neutrally, surface-charged SiO 2 NPs increased NO levels in differentiated Caco-2 cells. Exposure of differentiated Caco-2 cells to positively or negatively surface-charged SiO 2 NPs also upregulated interleukin-8 expression. We conclude that functionalized surface-charged SiO 2 NPs can induce pro-inflammatory responses but are noncytotoxic.

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Section: Discussionmentioning

confidence: 45%

Functionalized Surface-Charged SiO₂ Nanoparticles Induce Pro-Inflammatory Responses, but Are Not Lethal to Caco-2 Cells

Tada‐Oikawa

Eguchi

Yasuda

et al. 2020

Chem. Res. Toxicol.

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“…Poly-L-lysine (PL) is a homopolymer of L-lysine and reduces the production of IL-8 in the IECs induced by TNF- α ; thus, PL supplementation inhibits the expressions of proinflammatory cytokines by activating CaSR in the intestine [ 69 ]. Glucose-lysine Maillard reaction products (Glc-Lys MRPs) ameliorate DSS-induced colitis, increase glutathione content as well as antioxidant activities, and suppress the inflammatory cytokines and NF- κ B [ 70 , 71 ]; thus they can be used for preventing or treating IBD. Thr is a primary ingredient of intestinal IgA and mucins; thus, malnutrition of Thr induces inflammation and affects the immune responses through the NF- κ B pathway [ 72 ].…”

Section: Amino Acids and Intestinal Inflammationmentioning

confidence: 99%

Functions and Signaling Pathways of Amino Acids in Intestinal Inflammation

et al. 2018

BioMed Research International

150

115

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Intestine is always exposed to external environment and intestinal microorganism; thus it is more sensitive to dysfunction and dysbiosis, leading to intestinal inflammation, such as inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), and diarrhea. An increasing number of studies indicate that dietary amino acids play significant roles in preventing and treating intestinal inflammation. The review aims to summarize the functions and signaling mechanisms of amino acids in intestinal inflammation. Amino acids, including essential amino acids (EAAs), conditionally essential amino acids (CEAAs), and nonessential amino acids (NEAAs), improve the functions of intestinal barrier and expressions of anti-inflammatory cytokines and tight junction proteins but decrease oxidative stress and the apoptosis of enterocytes as well as the expressions of proinflammatory cytokines in the intestinal inflammation. The functions of amino acids are associated with various signaling pathways, including mechanistic target of rapamycin (mTOR), inducible nitric oxide synthase (iNOS), calcium-sensing receptor (CaSR), nuclear factor-kappa-B (NF-κB), mitogen-activated protein kinase (MAPK), nuclear erythroid-related factor 2 (Nrf2), general controlled nonrepressed kinase 2 (GCN2), and angiotensin-converting enzyme 2 (ACE2).

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“…2,3 Then the Amadori products are further reacted via dehydration, oxidation, cyclization, and other reactions to form melanoidins, advanced glycation end products (AGEs), and other chemicals. 4 The complex reactions ensure the various structures and bioactivities of Maillard reaction products, such as antioxidation, 5,6 antiproliferation, 7,8 and anti-inflammatory activity, 9,10 even though some AGEs also show undesirable bioactivity. 11,12 To date, antioxidant Maillard reaction products (MRPs) have attracted more attention owing to their free radical scavenging ability, chelating capacity, and reducing power.…”

Section: ■ Introductionmentioning

confidence: 99%

A New Compound Isolated from the Reduced Ribose–Tryptophan Maillard Reaction Products Exhibits Distinct Anti-inflammatory Activity

Qin

et al. 2018

J. Agric. Food Chem.

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In this study, a compound of 532.24 Da named BF-4 was separated from the ribose-tryptophan Maillard reaction products by solvent extraction and purified through reverse phase high performance liquid chromatography. The purified compound BF-4 was identified as 3-((1 H-indol-3-yl)methyl)-8-(5-((1 H-indol-3-yl)methyl)-6-oxomorpholin-2-yl)-9-hydroxy-1,7,4-dioxazecan-2-one in accordance with 1D- and 2D-NMR spectra and LC-ESI-MS/MS analysis. BF-4 significantly reduced the production of nitric oxide (NO), interleukin-6 (IL-6), and tumor necrosis factor α (TNF-α) in lipopolysaccharide-stimulated RAW 264.7 cells. It inhibited nuclear factor κB (NF-κB) activation and mitogen-activated protein kinase (MAPK) phosphorylation through suppressing phosphorylation of IκBα, P65, P38 and c-Jun N-terminal kinase (JNK). The anti-inflammatory activity of BF-4 was comparable to dexamethasone, and more importantly, BF-4 showed less cytotoxicity than dexamethasone on the normal human liver cell LO2. The results indicate that BF-4 is a promising anti-inflammatory agent with pharmaceutical potential.

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Anti-inflammatory effect of sugar-amino acid Maillard reaction products on intestinal inflammation model in vitro and in vivo

Cited by 23 publications

References 37 publications

Functionalized Surface-Charged SiO₂ Nanoparticles Induce Pro-Inflammatory Responses, but Are Not Lethal to Caco-2 Cells

Functionalized Surface-Charged SiO₂ Nanoparticles Induce Pro-Inflammatory Responses, but Are Not Lethal to Caco-2 Cells

Functions and Signaling Pathways of Amino Acids in Intestinal Inflammation

A New Compound Isolated from the Reduced Ribose–Tryptophan Maillard Reaction Products Exhibits Distinct Anti-inflammatory Activity

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Anti-inflammatory effect of sugar-amino acid Maillard reaction products on intestinal inflammation model in vitro and in vivo

Cited by 23 publications

References 37 publications

Functionalized Surface-Charged SiO2 Nanoparticles Induce Pro-Inflammatory Responses, but Are Not Lethal to Caco-2 Cells

Functionalized Surface-Charged SiO2 Nanoparticles Induce Pro-Inflammatory Responses, but Are Not Lethal to Caco-2 Cells

Functions and Signaling Pathways of Amino Acids in Intestinal Inflammation

A New Compound Isolated from the Reduced Ribose–Tryptophan Maillard Reaction Products Exhibits Distinct Anti-inflammatory Activity

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Functionalized Surface-Charged SiO₂ Nanoparticles Induce Pro-Inflammatory Responses, but Are Not Lethal to Caco-2 Cells

Functionalized Surface-Charged SiO₂ Nanoparticles Induce Pro-Inflammatory Responses, but Are Not Lethal to Caco-2 Cells