Anti-Inflammatory Effect of Violapyrones B and C from a Marine-derived<i>Streptomyces</i>sp.

Lee, Hwa Sun; An, Bong-Jeun; Kim, Yang Soo; Cho, Yong Hun; Kim, Dong In; Jang, Jae Yoon; Kwak, Jae Hoon; Lee, Hyi Seung; Lee, Yeon Ju; Lee, Jong Seok; Shin, Hee Jae

doi:10.20307/nps.2015.21.4.251

Cited by 5 publications

(5 citation statements)

References 13 publications

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“…Pyrones are a well-known class of microbial secondary metabolites and are found to have a wide range of biological activities such as anti-inflammatory [ 9 ], anticancer [ 10 ], antimicrobial [ 11 , 12 ], anti-obesity [ 13 , 14 ], and antibiotic activities [ 15 ]. Previous studies on microbial sources have shown that the main producer of α-pyrones is fungi, but α-pyrones are also produced by plants, animals, and bacteria.…”

Section: Resultsmentioning

confidence: 99%

Saccharomonopyrones A–C, New α-Pyrones from a Marine Sediment-Derived Bacterium Saccharomonospora sp. CNQ-490

Yim

Lee

et al. 2017

Marine Drugs

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Intensive study of the organic extract of the marine-derived bacterium Saccharomonospora sp. CNQ-490 has yielded three new α-pyrones, saccharomonopyrones A–C (1–3). The chemical structures of these compounds were assigned from the interpretation of 1D, 2D NMR and mass spectrometry data. Saccharomonopyrone A (1) is the first α-pyrone microbial natural product bearing the ethyl-butyl ether chain in the molecule, while saccharomonopyrones B and C possess unusual 3-methyl and a 6-alkyl side-chain within a 3,4,5,6-tetrasubstituted α-pyrone moiety. Saccharomonopyrone A exhibited weak antioxidant activity using a cation radical scavenging activity assay with an IC50 value of 140 μM.

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Section: Resultsmentioning

confidence: 99%

Saccharomonopyrones A–C, New α-Pyrones from a Marine Sediment-Derived Bacterium Saccharomonospora sp. CNQ-490

Yim

Lee

et al. 2017

Marine Drugs

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“…Gene clusters for other secondary metabolites like granaticin and violapyrone B were also detected in the genome of PBR1 stain. Granaticin is known to exhibit antibacterial and anticancer activities [ 96 ], and violapyrone B showed antibacterial, antitumor [ 97 ], and anti-influenza A (H1N1) activity [ 98 ].…”

Section: Discussionmentioning

confidence: 99%

Potentiality of Actinomycetia Prevalent in Selected Forest Ecosystems in Assam, India to Combat Multi-Drug-Resistant Microbial Pathogens

2023

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Actinomycetia are known for their ability to produce a wide range of bioactive secondary metabolites having significant therapeutic importance. This study aimed to explore the potential of actinomycetia as a source of bioactive compounds with antimicrobial properties against multi-drug-resistant (MDR) clinical pathogens. A total of 65 actinomycetia were isolated from two unexplored forest ecosystems, namely the Pobitora Wildlife Sanctuary (PWS) and the Deepor Beel Wildlife Sanctuary (DBWS), located in the Indo-Burma mega-biodiversity hotspots of northeast India, out of which 19 isolates exhibited significant antimicrobial activity. 16S rRNA gene sequencing was used for the identification and phylogenetic analysis of the 19 potent actinomycetia isolates. The results reveal that the most dominant genus among the isolates was Streptomyces (84.21%), followed by rare actinomycetia genera such as Nocardia, Actinomadura, and Nonomuraea. Furthermore, seventeen of the isolates tested positive for at least one antibiotic biosynthetic gene, specifically type II polyketide synthase (PKS-II) and nonribosomal peptide synthetases (NRPSs). These genes are associated with the production of bioactive compounds with antimicrobial properties. Among the isolated strains, three actinomycetia strains, namely Streptomyces sp. PBR1, Streptomyces sp. PBR36, and Streptomyces sp. DBR11, demonstrated the most potent antimicrobial activity against seven test pathogens. This was determined through in vitro antimicrobial bioassays and the minimum inhibitory concentration (MIC) values of ethyl acetate extracts. Gas chromatography–mass spectrometry (GS-MS) and whole-genome sequencing (WGS) of the three strains revealed a diverse group of bioactive compounds and secondary metabolite biosynthetic gene clusters (smBGCs), respectively, indicating their high therapeutic potential. These findings highlight the potential of these microorganisms to serve as a valuable resource for the discovery and development of novel antibiotics and other therapeutics with high therapeutic potential.

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“…Furthermore, these interactions play an influential factor in the evolution of the gene pool for Streptomyces specialized metabolism [ 49 ]. It is imperative to expand this type of research, involving symbiotic microorganisms from marine environments, as it was evidently the less explored condition (only eight articles evaluated Streptomyces isolated from marine organisms—two ascidians [ 187 , 189 ], three corals [ 184 , 185 , 186 ], one jellyfish [ 190 ], one sponge [ 183 ] and one starfish [ 188 ]).…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, the fact that several compounds have shown positive results in a variety of methods also shows that the metabolites might have different ways to produce an anti-inflammatory action. Several compounds were active at micromolar concentrations [ 145 , 147 , 148 , 162 , 163 , 164 , 175 , 176 , 178 , 181 , 188 , 198 , 199 ]; even more, some metabolites were as active as reference drugs used in their respective assays. Additionally, a very remarkable case is FK-506 (also known as tacrolimus).…”

Section: Discussionmentioning

confidence: 99%

Streptomyces-Derived Metabolites with Potential Photoprotective Properties—A Systematic Literature Review and Meta-Analysis on the Reported Chemodiversity

et al. 2020

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Sun overexposure is associated with the development of diseases that primarily affect the skin, which can lead to skin cancer. Among the main measures of photoprotection is the use of sunscreens. However, there is currently concern about the reported harmful effects to both humans and the environment due to several of the sunscreen ingredients available on the market. For this reason, the search for and development of new agents with photoprotective properties is required. In searching for these metabolites, researchers have turned their attention to microbial sources, especially the microbiota in unusual hostile environments. Among the diverse microorganisms available in nature, Actinobacteria and specifically Streptomyces, have been shown to be a source of metabolites with various biological activities of interest, such as antimicrobial, antitumor and immunomodulator activities. Herein, we present the results of a systematic review of the literature in which Streptomyces isolates were studied as a source of compounds with photoprotective properties. A meta-analysis of the structure-property and structure-activity relationships of those metabolites identified in the qualitative analysis phase was also carried out. These findings indicate that Streptomyces are a source of metabolites with potential applications in the development of new, safe and more eco-friendly sunscreens.

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Anti-Inflammatory Effect of Violapyrones B and C from a Marine-derivedStreptomycessp.

Cited by 5 publications

References 13 publications

Saccharomonopyrones A–C, New α-Pyrones from a Marine Sediment-Derived Bacterium Saccharomonospora sp. CNQ-490

Saccharomonopyrones A–C, New α-Pyrones from a Marine Sediment-Derived Bacterium Saccharomonospora sp. CNQ-490

Potentiality of Actinomycetia Prevalent in Selected Forest Ecosystems in Assam, India to Combat Multi-Drug-Resistant Microbial Pathogens

Streptomyces-Derived Metabolites with Potential Photoprotective Properties—A Systematic Literature Review and Meta-Analysis on the Reported Chemodiversity

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