Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice

Key cell signaling pathways modulated by zerumbone: Role in the prevention and treatment of cancer

“…This sesquiterpene was also found to suppress fatty liver formation due to overdosage of ethanol administration in rats, further supporting the hepatoprotective property [76]. Intraperitoneal administration of zerumbone at a dose of 5, 10, 50 and 100 mg/kg was reported to produce dosedependent inhibition of carrageenan-induced paw edema in mice, indicating anti-inflammatory activity [77]. Zerumbone also suppressed granulomatous tissue formation in cotton pelletinduced granuloma test in mice [77].…”

“…Intraperitoneal administration of zerumbone at a dose of 5, 10, 50 and 100 mg/kg was reported to produce dosedependent inhibition of carrageenan-induced paw edema in mice, indicating anti-inflammatory activity [77]. Zerumbone also suppressed granulomatous tissue formation in cotton pelletinduced granuloma test in mice [77]. In a recent study, zerumbone was reported to protect mouse cornea from ultraviolet B (UVB)-induced inflammatory photokeratitis with inhibition of NF-kB, iNOS and TNF-a expression, abrogation of nuclear translocation of NF-kB, reduction of malonyldialdehyde accumulation and increase of GSH and glutathione reductase levels [78].…”

Preliminary comparative study of anti-inflammatory effect of unheated and heat-treated Sahara honey: In vivo approach

“…The first phase (1 h) involves the release of serotonin and histamine and the second phase (> 1 h) is mediated by cyclooxygenase products and the continuity between the two phases is provided by kinins [15,16]. Prostaglandins (PG) (PGE2) play an essential role in inflammation [17].…”

Effects on Renal Histology, Renal Metabolizing Enzymes and Oxidative Stress Biomarkers in Rats Administered Zerumbone Against Osteoarthritis

“…Extensive studies were carried out through the last decade on zerumbone anti-inflammatory (Sulaiman et al, 2010), anti-oxidant (Ibrahim et al, 2010) and anti-cancer efficiencies (Al-Zubairi et al, 2010). Previously it was established that the dietary administration of zerumbone Glutathione S-Transferase (GST), which is one of the important phase II metabolizing enzymes is a large family of isozymes, play a role in intracellular transport of hydrophobic molecules through their conjugation with the reduced form of the intracellular glutathione (Korkina et al, 2009).…”