Anti-inflammatory effects of 7-hydroxyl-1-methylindole-3-acetonitrile, a synthetic arvelexin derivative, on the macrophages through destabilizing mPGES-1 mRNA and suppressing NF-κB activation

Shin, Ji‐Sun; Choi, Hyun‐Chul; Kim, Soo Dong; Lee, Yong Sup; Cho, Young-Wuk; Lee, Kyung Tae

doi:10.1016/j.cbi.2014.10.004

Cited by 13 publications

(2 citation statements)

References 37 publications

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“…The control of cytokine production and cell survival in cellular responses to stimulators such as ROS, bacterial or viral antigens are caused by NF-κB, which is present in almost all animal cell types [ 13 ]. By contraries, suppression of transcriptional activities of NF-κB attenuates the release of inducible NO synthase (iNOS), cyclooxygenases-2 (COX-2), prostaglandin E2 synthases (PTGEs) and tumor necrosis factor-α (TNF-α) [ 19 ], indicating up- and downstream relationships. NF-κB is also involved in T-cell development and functional divergence, such as helper T cell (Th) 1 and Th2 differentiation [ 20 ], which are responsible for immunity against intracellular/extracellular pathogens respectively.…”

Section: Introductionmentioning

confidence: 99%

Copper or/and arsenic induce oxidative stress-cascaded, nuclear factor kappa B-dependent inflammation and immune imbalance, trigging heat shock response in the kidney of chicken

et al. 2017

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Excessive amount of copper (Cu) and inorganic arsenic (iAs) coexists in drinking water in many regions, this is associated with high risk of nephropathy, defined as chronic structural and functional disorders of the kidney. However, the underlying mechanisms are not well understood. In this study, a total of 72 day-old Hy-line chickens were exposed to 300 mg/kg copper sulphate or/and 30 mg/kg arsenic trioxide for 12 weeks. Indicators of oxidative stress, inflammation and heat shock proteins (HSPs) production were analyzed in kidney. The results showed that, when the toxicant was administrated alone, there is an antagonism between redox homeostasis during the first 4 weeks, which follows a collapse of antioxidant system manifested by damaged biomembrane structure. What's worse, oxidative damage-cascaded histopathological lesions were accompanied by increases of proinflammatory mediators and an imbalance of “Th1/Th2 drift” (Th, helper T cell) regulated by nuclear factor kappa B (NF-κB). Simultaneously, intense heat shock response went with the organism. The above-mentioned renal lesions and indicators changes were time-dependent, more complex and deteriorated effects were observed in Cu/iAs combined groups compared with the others. This study supports Cu and iAs have a synergistic type on the nephro-toxicological process additively. In conclusion, oxidative stress and inflammatory induced by Cu or/and iAs are potential mechanisms in their nephrotoxicity, increased heat shock response may play a renoprotection function in tissues damage.

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Section: Introductionmentioning

confidence: 99%

Copper or/and arsenic induce oxidative stress-cascaded, nuclear factor kappa B-dependent inflammation and immune imbalance, trigging heat shock response in the kidney of chicken

et al. 2017

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“…Tryptanthrin can also significantly reduce the level of thymic stromal lymphopoietin (TSLP) in lesional skin in an atopic eczema animal model, and thus can improve the clinical symptoms within this animal model ( 13 ). Indole acetonitrile derivatives, products from the enzymatic degradation of indole glucosinolates, are other major compounds in woad, which strongly inhibit production of nitric oxide and prostaglandin E2 (PGE2), release of tumour necrosis factor (TNF)-α, and interleukin (IL)-6 from macrophages, and show anti-inflammatory properties in vivo ( 14 , 15 ). For the woad compound p-coumaric acid methyl ester, an anti-allergic effect, via inhibition of mast cell degranulation, could be detected, which is due to the modulation of hydrophobicity and alkyl chain bulkiness in RBL-2H3 cells ( 16 ).…”

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confidence: 99%

Isatis tinctoria L.-derived Petroleum Ether Extract Mediates Anti-inflammatory Effects via Inhibition of Interleukin-6, Interleukin-33 and Mast Cell Degranulation

Lotts¹,

Kabrodt²,

Hummel³

et al. 2020

Acta Derm Venerol

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The medicinal herb Isatis tinctoria (woad), which has been used in medicine for centuries, has demonstrated antiinflammatory effects in recent studies. However, to date, no defined extracts with precise characterization of their active substance content have been developed. This study aimed to develop novel well-characterized extracts of woad, and to determine their anti-inflammatory properties in animal and human skin tissues. The production and precise characterization of such extracts will enable evaluation of their potential dermatological use in the treatment of irritated, pruritic skin. Isatis tinctoria L. (woad) has been used in medicine for centuries and has demonstrated anti-inflammatory effects. However, to date, no well-defined extracts with precise analysis of active substances have been developed. The aim of this study was to develop novel extracts of Isatis tinctoria L., and to characterize their active ingredients and anti-inflammatory properties. Various extracts of Isatis tinctoria L. were analysed for their active ingredients, and screened for anti-inflammatory effects using cyclooxygenase-2 activity assays. A petroleum ether extract was found to have the best effects, and was tested in a mouse model of acute allergic contact dermatitis. In the mouse model the petroleum ether extract resulted in significantly reduced ear swelling, oedema and inflammatory cell density. In mouse skin and human keratinocyte cultures, petroleum ether extract inhibited pro-inflammatory cytokine expression. Furthermore, human mast cell degranulation was significantly inhibited in LAD2 cell cultures. In conclusion, novel woad extracts were developed and shown to have anti-inflammatory properties in a contact hypersensitivity animal model and human keratinocytes. The production of such extracts and further characterization of their specific properties will enable determination of their potential dermatological effects in the treatment of inflamed and irritated skin.

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Synthesis and inhibitory effects of triarylpyrazoles on LPS-induced NO and PGE2 productions in RAW 264.7 macrophages

et al. 2017

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Anti-inflammatory effects of 7-hydroxyl-1-methylindole-3-acetonitrile, a synthetic arvelexin derivative, on the macrophages through destabilizing mPGES-1 mRNA and suppressing NF-κB activation

Cited by 13 publications

References 37 publications

Copper or/and arsenic induce oxidative stress-cascaded, nuclear factor kappa B-dependent inflammation and immune imbalance, trigging heat shock response in the kidney of chicken

Copper or/and arsenic induce oxidative stress-cascaded, nuclear factor kappa B-dependent inflammation and immune imbalance, trigging heat shock response in the kidney of chicken

Isatis tinctoria L.-derived Petroleum Ether Extract Mediates Anti-inflammatory Effects via Inhibition of Interleukin-6, Interleukin-33 and Mast Cell Degranulation

Synthesis and inhibitory effects of triarylpyrazoles on LPS-induced NO and PGE2 productions in RAW 264.7 macrophages

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