Anti-inflammatory effects of Bryophyllum pinnatum (Lam.) Oken ethanol extract in acute and chronic cutaneous inflammation

Chibli, Lucas Apolinário; Rodrigues, Kamilla Coelho Morais; Gasparetto, Carolina Miranda; Pinto, Nícolas de Castro Campos; Fabri, Rodrigo Luiz; Scio, Elita; Alves, Maria Silvana; Del-Vechio-Vieira, Glauciemar; Sousa, Orlando Vieira de

doi:10.1016/j.jep.2014.03.035

Cited by 87 publications

(65 citation statements)

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“…Mice receiving daily oral treatment with B. pinnatum aqueous leaf extracts during a 14-day sensitization (ovalbumin, OVA) period were protected from fatal anaphylactic shock. Quercitrin (30) had a protective effect in 75% of the animals and appeared to be important for the antianaphylactic effect of the extract. Furthermore, the aqueous leaf extract reduced eosinophilia as well as IL-5, IL-10, and TNF-α cytokine production [92].…”

Section: Antioxidant Activitymentioning

confidence: 94%

“…In a recent study, the inhibitory effect of a B. pinnatum ethanolic extract was investigated in Swiss albino mice on ear edema induced by various irritant agents such as croton oil, capsaicin, and phenol. Depending on the irritant agent, extract doses of 0.1 mg/ear or 0.5 mg/ear showed significant inhibition [30]. Also, an aqueous extract of the flowers and the quercetin diglycoside 29 inhibited croton oil-induced ear edema and reduced leucocyte migration in carrageenan-induced pleurisy in mice.…”

Section: Anti-inflammatory Activitymentioning

confidence: 98%

“…They include numerous flavonol derivatives , mainly quercetin and kaempferol glycosides, as well as a few flavone glycosides, such as acacetin, luteolin, and diosmetin glycosides (36-40) (l " Table 2, Fig. 2) [13,[25][26][27][28][29][30][31][32][33][34][35][36]. In addition, epigallocatechin-3-Osyringate (41) [36] and an ethenylamino-substituted anthocyanidin with a biogenetically unlikely structure [37] have been reported.…”

Section: Flavonoidsmentioning

confidence: 99%

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Bryophyllum pinnatum and Related Species Used in Anthroposophic Medicine: Constituents, Pharmacological Activities, and Clinical Efficacy

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ReviewsThis document was downloaded for personal use only. Unauthorized distribution is strictly prohibited.Bryophyllum (see below) [4]. While these reviews describe various compounds and bioactivities, none of them addresses the pharmacological and clinical data that support the therapeutic use of Bryophyllum preparations in European countries. The present review focuses on B. pinnatum, but the few data available on Bryophyllum daigremontianum, Bryophyllum delagoense, and the hybrid Bryophyllum daigremontianum x tubiflorum have also been included. The German homeopathic pharmacopeia (HAB) 2014 [5] lists the two species B. pinnatum and B. daigremontianum as officinal in its monography "Bryophyllum Rh", and both have been used in AM. B. delagoense was introduced in the 1980s as an anthroposophic medicinal product in Germany, primarily for sedative purposes (Personal communication, Dr. med. Siegward-M. Elsas, see Acknowledgments). Botany

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Section: Antioxidant Activitymentioning

confidence: 94%

Section: Anti-inflammatory Activitymentioning

confidence: 98%

Section: Flavonoidsmentioning

confidence: 99%

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Bryophyllum pinnatum and Related Species Used in Anthroposophic Medicine: Constituents, Pharmacological Activities, and Clinical Efficacy

et al. 2016

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“…To accompany the baseline in the groups, 20 μl of acetone (vehicle) were applied in the left ear 22 . After 15 min, the right ears were treated with EEVPB or EFVPB (0.1, 0.5 and 1.0 mg/ear), and dexamethasone (0.1 mg/ear, positive control), while the negative control (untreated) received 20 μl of acetone.…”

Section: Test Of Iron Reducing Powermentioning

confidence: 99%

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2017

IJPSR

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Vernonia polyanthes Less. (Asteraceae) is a medicinal plant that has been broadly used in Brazil for the treatment of inflammation and cutaneous damages. The present study evaluated the phytochemical contents and the antioxidant and topical anti-inflammatory activities of the V. polyanthes branches. Dried and powdered of V. polyanthes branches were exhaustively extracted with ethanol by static maceration followed by partition to obtain the hexane, dichloromethane, ethyl acetate, and butanol fractions. Phytochemical screening and the total phenolic and flavonoid contents were determined using chemical reactions and spectrophotometry, respectively. The antioxidant activity was evaluated by DPPH, reducing power of Fe +3 and β-carotene/linoleic acid assays. The topical antiinflammatory effects of the ethanol extract (EEVPB) and ethyl acetate fraction (EFVPB) were investigated in Croton oil-, arachidonic acid-, and phenol-induced ear edema models. Tannins, flavonoids, coumarins, terpenoids and steroids, saponins and alkaloids were detected in the ethanol extract and/or fractions. In these samples, the total phenolic and flavonoid contents varied from 0.65 ± 0.07 to 12.58 ± 0.67 g/100 g and 0.15 ± 0.02 to 4.75 ± 0.21 g/100 g, respectively. After topical application, EEVPB and EFVPB significantly (p < 0.01 or p < 0.001) reduced ear edema induced by three phlogistic agents (0.1, 0.5 or 1.0 mg/ear). These results suggest that V. polyanthes is an important and promising source of bioactive compounds with relevant biological properties and can be used as a strategy to develop new products for the treatment of skin conditions related to oxidative damage.

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“…However, several studies pointed out the association between long-term usage of synthetic drugs and adverse side effects such as bleeding, hepatic failure, asthma, skin rashes, renal failure and ulceration (Dinarello 2010;Chibli et al 2014). Hence, the replacement of commercially available synthetic anti-inflammatory drugs with safer natural products is much desired.…”

Section: Introductionmentioning

confidence: 99%

Citrus hallabong [(Citrus unshiu × C. sinensis) × C. reticulata)] exerts potent anti-inflammatory properties in murine splenocytes and TPA-induced murine ear oedema model

Herath

Bing

Cho

et al. 2016

Pharmaceutical Biology

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þ memory T-cell population, an important marker for anti-inflammatory activity, and a significant inhibition in the production of IL-2 and IFN-c. HE treatment had reduced the mouse skin oedema (47%) and myeloperoxidase (MPO) activity significantly (40%) in TPA-challenged tissues. More importantly, immunohistochemical localization revealed the suppressed (p < 0.05) expression of inducible nitric oxide (iNOS), cyclooxygenase-2 (COX2). HE decreased the infiltration of CD3 þ T cells and F4/80 þ macrophages to the site of inflammation and a topical application of HE significantly suppressed the expression of TNF-a (20.2%). Discussion and conclusion: A topical application of HE can exert a potential anti-inflammatory effect and HE can be explored further as a putative alternative therapeutic agent for inflammatory oedema. ARTICLE HISTORY

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Anti-inflammatory effects of Bryophyllum pinnatum (Lam.) Oken ethanol extract in acute and chronic cutaneous inflammation

Cited by 87 publications

References 40 publications

Bryophyllum pinnatum and Related Species Used in Anthroposophic Medicine: Constituents, Pharmacological Activities, and Clinical Efficacy

Bryophyllum pinnatum and Related Species Used in Anthroposophic Medicine: Constituents, Pharmacological Activities, and Clinical Efficacy

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Citrus hallabong [(Citrus unshiu × C. sinensis) × C. reticulata)] exerts potent anti-inflammatory properties in murine splenocytes and TPA-induced murine ear oedema model

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