Anti-inflammatory effects of ginsenoside Rg1 and its metabolites ginsenoside Rh1 and 20(S)-protopanaxatriol in mice with TNBS-induced colitis

Lee, Sang-Yun; Jeong, Jin-Ju; Eun, Su-Hyeon; Kim, Dong‐Hyun

doi:10.1016/j.ejphar.2015.06.011

“…Regarding the baseline characteristic item, seven studies showed the balance of relevant baseline characteristics between the control group and the intervention group [38,45,47,48,50,58,59]. No study noted any adjustment if the unequal distribution of some relevant baseline characteristics in analysis had existed.…”

Section: Methodological Quality Of Studiesmentioning

confidence: 99%

“…He et al [34] reported no significant effect of G-Rh1 in the range of 0.1-10 µM on the activity of NF-κB luciferase reporter activity in human embryonic kidney 293 (HEK 293) cells induced by TNF-α (10 ng/mL). However, significant inhibition of NF-κB activation by G-Rh1 was also reported in HEK 293 cells pretreated with TNF-α [35], in BV2 glioma cells induced by LPS [36] or IFN-γ [37], in macrophages stimulated by LPS or TNBS [38], and in murine macrophage RAW 264.7 cells treated with LPS [39] or TNF-α [22]. Both He et al [34] and Xing et al [35] assessed the protective effect of G-Rh1 on the activation of NF-κB on HEK 293 cells induced by TNF-α.…”

Section: Anticancer Effectsmentioning

confidence: 99%

“…After oral administration at a dose of 20 mg/kg, G-Rh1 inhibited colon shortening, lowered myeloperoxidase activity, and suppressed the expression of IL-1β, IL-17, and TNF-α in mice with TNBS-induced colitis [38], suppressed body weight gain, epididymal fat weight, and plasma triglyceride levels in high-fat diet-induced obesite mice [42], as well as suppressed ear swellings and ear weight, and decreased IL-6 in the serum of hairless mice with atopic dermatitis-like skin lesions [44]. Gu et al [42] indicated the effective attenuation of body weight gain, epididymal fat weight, and plasma triglyceride levels in obese mice.…”

Section: Anticancer Effectsmentioning

confidence: 99%

See 1 more Smart Citation

Untitled

2018

Planta Med

0

View full text Add to dashboard Cite

Supporting information available online at http://www.thieme-connect.de/products ABSTR AC TGinsenoside Rh1 is one of major bioactive compounds extracted from red ginseng, which has been increasingly used for enhancing cognition and physical health worldwide. The objective of this study was to review the pharmacological effects of ginsenoside Rh1 in a systematic manner. We performed searches on eight electronic databases including MEDLINE (Pubmed), Scopus, Google Scholar, POPLINE, Global Health Library, Virtual Health Library, the System for Information on Grey Literature in Europe, and the New York Academy of Medicine Grey Literature Report to select the original research publications reporting the biological and pharmacological effects of ginsenoside Rh1 from in vitro and in vivo studies regardless of publication language and study design. Upon applying the inclusion and exclusion criteria, we included a total of 57 studies for our systemic review. Ginsenoside Rh1 exhibited the potent characteristics of anti-inflammatory, antioxidant, immunomodulatory effects, and positive effects on the nervous system. The cytotoxic effects of ginsenoside Rh1 were dependent on different types of cell lines. Other pharmacological effects including estrogenic, enzymatic, anti-microorganism activities, and cardiovascular effects have been mentioned, but the results were considerably diverged. A higher quality of evidence on clinical trial studies is highly recommended to confirm the consistent efficacy of ginsenoside Rh1.

show abstract

“…Four trials provided information about conflicts of interest [38,45,46,70]. Finally, we have no details to verify unit of analysis errors and whether new animals had been added to replace dropouts from the original population.…”

Section: Methodological Quality Of Studiesmentioning

confidence: 99%

Ginsenoside Rh1: A Systematic Review of Its Pharmacological Properties

Tam

¹

,

Truong

²

,

Nguyen

³

et al. 2018

View full text Add to dashboard Cite

Supporting information available online at http://www.thieme-connect.de/products ABSTR AC TGinsenoside Rh1 is one of major bioactive compounds extracted from red ginseng, which has been increasingly used for enhancing cognition and physical health worldwide. The objective of this study was to review the pharmacological effects of ginsenoside Rh1 in a systematic manner. We performed searches on eight electronic databases including MEDLINE (Pubmed), Scopus, Google Scholar, POPLINE, Global Health Library, Virtual Health Library, the System for Information on Grey Literature in Europe, and the New York Academy of Medicine Grey Literature Report to select the original research publications reporting the biological and pharmacological effects of ginsenoside Rh1 from in vitro and in vivo studies regardless of publication language and study design. Upon applying the inclusion and exclusion criteria, we included a total of 57 studies for our systemic review. Ginsenoside Rh1 exhibited the potent characteristics of anti-inflammatory, antioxidant, immunomodulatory effects, and positive effects on the nervous system. The cytotoxic effects of ginsenoside Rh1 were dependent on different types of cell lines. Other pharmacological effects including estrogenic, enzymatic, anti-microorganism activities, and cardiovascular effects have been mentioned, but the results were considerably diverged. A higher quality of evidence on clinical trial studies is highly recommended to confirm the consistent efficacy of ginsenoside Rh1.

show abstract

“…For instance, GRg1 was reported to enhance CD4 + T-cell activities, modulate type I helper cell (Th1)/Th2 differentiation and increase the ratio of CD3 + CD4 + to CD3 + CD8 + T cells and CD4 + CD25 + forkhead box (Fox)p3 + regulatory T cells in the blood in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mice (6)(7)(8). Furthermore, GRg1, GRh1 and 20(S)-protopanaxtriol not only inhibited 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced nuclear factor-κB activation but restored TNBS-induced Th17/T-regulatory cell (Treg) imbalance (9). In addition, GRp1 was revealed to promote the differentiation of the memory types of CD4 + Foxp3 + CD62L(low) Tregs (10).…”

Section: Introductionmentioning

confidence: 99%

Regulatory effects of four ginsenoside monomers in humoral immunity of systemic lupus erythematosus

Yu

¹

,

Zhang

²

,

Lin

³

et al. 2017

View full text Add to dashboard Cite

Abstract. Ginsenosides Rb1, Rh1, Rg1 and Rg3 are known as the main active components extracted from the roots of the Panax ginseng C.A. Meyer, and were reported to have immunoregulatory effects. Disruption of B-cell immune regulation during the pathogenesis of systemic lupus erythematosus (SLE) may lead to the production of large amounts of antibodies. The present study investigated the effects of the four ginsenoside monomers on B-cell immune regulation and observed that they inhibited the proliferation and secretion of B cells induced by LPS, caused an upregulation of the expression of apoptosis-associated proteins Fas/Fas ligand and caspase-3, the expression of FcγRIIB (CD32) as well as the proportion of inactive B cells (CD19 + CD27 -). These results indicate that Rb1, Rh1, Rg1 and Rg3 inhibit the humoral immunity of SLE, among which Rh1 exhibited the most obvious inhibitory effect.

show abstract

Anti-inflammatory effects of ginsenoside Rg1 and its metabolites ginsenoside Rh1 and 20(S)-protopanaxatriol in mice with TNBS-induced colitis

Cited by 112 publications

References 36 publications

Untitled

Untitled

Ginsenoside Rh1: A Systematic Review of Its Pharmacological Properties

Regulatory effects of four ginsenoside monomers in humoral immunity of systemic lupus erythematosus

Contact Info

Product

Resources

About