Anti-inflammatory effects of green soybean extract irradiated with visible light

Tanaka, Keiko; Ohgo, Yasushi; Katayanagi, Yuki; Yasui, Kensuke; Hiramoto, Shigeru; Ikemoto, Hiroyuki; Nakata, Yumi; Miyoshi, Noriyuki; Isemura, Mamoru; Ohashi, Norio; Imai, Shoichi

doi:10.1038/srep04732

Cited by 32 publications

(43 citation statements)

References 21 publications

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“…and several other plants [118][119][120][121]. Beta-sitosterol D-glucoside has many pharmacological activities [118][119][120][121][122][123][124] such as androgenic, antiadenomic, anticancer [129][130][131][132][133][134], antiedemic [135], and antiinflammatory [136][137][138][139][140][141][142]. Sitosterol has a structure such as cholesterol that later in the body can become the precursor of testosterone and The maximum score of the addition is eight [40,94] has been supposed to have an antifertility, and sex steroids have been implicated in the development and maintenance of Benign prostatic hyperplasia (BPH) and use of androgen reducing compounds, such as 5α-reductase inhibitors which block the conversion of testosterone into dihydrotestosterone [14,32,52].…”

Section: Discussionmentioning

confidence: 99%

Transforming Growth Factor Beta of Testis Germinal Cell in Guinea Pig (Cavia Porcellus) After Exposure to Methanol Extract of the Seeds of Bitter Melon (Momordica Charantia) and Depot Medroxyprogesterone Acetate

Ilyas

Hutahaean

Nursal

2018

Asian J Pharm Clin Res

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Objective: The discovery of male contraceptive drugs continues to be pursued, due to the very small participation of men associated with the lack of contraceptiveÐptions for men. The combination of methanol extract of bitter melon seed and depot medroxyprogesterone acetate (DMPA) becomes the choice that currently being pursued to be applied to men. Methods:The use of guinea pigs as experimental animals conducted research using experimental methods with complete randomized design. The study was divided into four control groups i.e K0; dimethylsulfoxide (DMSO) for 0 week (4 h),K1; Control group of DMSO for 4 weeks, K2; Control group of DMSO for 8 weeks, K3; Control group of DMSO for 12 weeks, and four treatment groups, i.e: group P0; bitter melon seed extract of 50 mg/100g body weight/day for 0 week (4 h), group P1; Bitter melon seed extract of 50 mg/100g BW/day for 4 weeks+DMPA, group P2; Bitter melon seed extract of 50 mg/100g BW/day for 8 weeks+DMPA, P3 group; Bitter melon seed extract of 50 mg/100g BW/day for 12 weeks+DMPA.Results: There was a significant effect (p<0.05) methanol extract of bitter melon seed to increase the transforming growth factor expression -β expression. Conclusion:The methanol extract of bitter melon seed was able to be candidate for herbal contraception.

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Section: Discussionmentioning

confidence: 99%

Transforming Growth Factor Beta of Testis Germinal Cell in Guinea Pig (Cavia Porcellus) After Exposure to Methanol Extract of the Seeds of Bitter Melon (Momordica Charantia) and Depot Medroxyprogesterone Acetate

Ilyas

Hutahaean

Nursal

2018

Asian J Pharm Clin Res

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“…In the present study, we focused on green soybean and compared the effect on brain function relative to a yellow soybean cultivar. While yellow soybeans, which are the most abundant and have mainly been studied, green soybean extract (GSE) was recently reported to have immune-modulatory and anti-inflammatory effects [8,9]. In addition, we recently reported that the ingestion of GSE ameliorated cognitive dysfunction and amyloid β (Aβ) accumulation in aged senescence-accelerated mice (SAMP10) [10].…”

Section: Introductionmentioning

confidence: 99%

Improvement in Cognitive Function with Green Soybean Extract May Be Caused by Increased Neuritogenesis and BDNF Expression

Minami¹,

Nakayama²,

Kimura³

et al. 2017

J Food Process Technol

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Green soybean (Glycine max L.), which was used in this study, retains the green color of the seed coat cotyledon even after ripening, even though many soybean cultivars become yellow during maturation. We have reported that ingestion of green soybean extract (GSE) suppressed cognitive dysfunction and reduced amyloid β accumulation more than yellow soybean extract (YSE) in aged senescence-accelerated (SAMP10) mice, a mouse model of brain senescence. To clarify the mechanism by which GSE suppresses cognitive dysfunction, we examined the effect of GSE and YSE on neurite outgrowth in human neuroblastoma SHSY-5Y cells. GSE significantly increased cell number and neurite outgrowth at 5 ng/ml (as isoflavones, 30 pg/ml), but the effect of YSE was lower than that of GSE. Although isoflavone aglycones, genistein and daidzein increased the number of SH-SY5Y cells, the effect was only observed at a high concentration [0.05 µM (13 ng/ml)]. ICR mice were fed a diet containing 3% soybean extract for 3 weeks (3-4 g/kg; as isoflavones, ca. 20 mg/kg) to examine cognitive function. Learning and memory abilities, as evaluated by a step-through passive avoidance task, a Y-maze and a novel object recognition test, were significantly higher in mice that ingested GSE than control mice that were fed a normal diet. The expression of brain-derived neurotrophic factor (BDNF) in the hippocampus, as detected by western blot analysis, was higher in mice that ingested GSE than in control mice. This study suggests that the ingestion of GSE enhances learning and memory abilities in mice. The effect by which GSE improved cognitive function appears to be caused, in part, by increased neuritogenesis and BDNF expression. In the present study, in order to clarify the mechanism by which GSE suppresses brain aging, we first examined the effects of GSE and yellow soybean extract (YSE) on SH-SY5Y cells, which have been used to observe neurotrophic activity-inducing neurite outgrowth as well as cell number growth in cell culture system [18,19]. This activity was compared with that of soy isoflavones such as genistein and daidzein. We also examined whether a relatively short period of administration of GSE could alter learning and memory abilities of young mice using a Y-maze, novel-object recognition and a step-through passive avoidance task. In addition, since brain-derived neurotrophic factor (BDNF) is a key mediator involved in both neurogenesis and cognitive function, we examined the expression of BDNF in the hippocampus of mice that ingested GSE. Improvement in Cognitive Function Materials and Methods Preparation of soybean extractJapanese cultivars of green soybean ('Echigomidori') and yellow soybean ('Fukuyutaka') were used. Soybeans (10 g) crushed into a

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“…To date, several pharmacological studies on puerarin, daidzin have been performed, applying liquid chromatography (LC), joint liquid chromatography with mass spectrometry (LC-MS), and liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS) to provide chemical properties of investigated compounds [10][11][12]. NMR chemical shifts of daidzein and puerarin have also been measured [13][14][15]; however, magnetic shielding has never been reported for either compound. The present work reports experimental 1 H and 13 C NMR chemical shifts of daidzein and puerarin dissolved in methanol-d 4 .…”

Section: Introductionmentioning

confidence: 99%

“…NMR chemical shifts of daidzein and puerarin have also been measured [13][14][15]; however, magnetic shielding has never been reported for either compound. The present work reports experimental 1 H and 13 C NMR chemical shifts of daidzein and puerarin dissolved in methanol-d 4 . For the same solutions, we also completed measurements of magnetic shielding using an original method from our laboratory [16].…”

Section: Introductionmentioning

confidence: 99%

NMR studies of daidzein and puerarin: active anti-oxidants in traditional Chinese medicine

Yang

Adrjan

et al. 2019

J Mol Model

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Radix puerariae-a popular traditional Chinese medicine-is used for the treatment of diarrhea, acute dysentery, deafness, and cardiovascular diseases. It can also be used as an effective antioxidant and has been tested as an anticancer drug. Daidzein and puerarin are its main active compounds. The present contribution was focused on experimental and theoretical studies of the 1 H and 13 C NMR chemical shifts and nuclear magnetic shielding parameters of daidzein and puerarin. Experimental data were gained by exploring standard one-dimensional spectra and a set of two-dimensional measurements: COSY, HSQC, and HMBC. The theoretical gauge independent atomic orbital density functional theory supporting studies, were performed to determine shielding constants and chemical shifts in vacuum and methanol-d4 solvent. The correlation between experimental and theoretical data was fairly good, especially when the DFT/PBE0 approach was used. The molecular properties of daidzein and puerine related to antiradical activity were studied in the context of a single-step hydrogen atom transfer mechanism and its correlation with 13 C NMR chemical shifts.

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Anti-inflammatory effects of green soybean extract irradiated with visible light

Cited by 32 publications

References 21 publications

Transforming Growth Factor Beta of Testis Germinal Cell in Guinea Pig (Cavia Porcellus) After Exposure to Methanol Extract of the Seeds of Bitter Melon (Momordica Charantia) and Depot Medroxyprogesterone Acetate

Transforming Growth Factor Beta of Testis Germinal Cell in Guinea Pig (Cavia Porcellus) After Exposure to Methanol Extract of the Seeds of Bitter Melon (Momordica Charantia) and Depot Medroxyprogesterone Acetate

Improvement in Cognitive Function with Green Soybean Extract May Be Caused by Increased Neuritogenesis and BDNF Expression

NMR studies of daidzein and puerarin: active anti-oxidants in traditional Chinese medicine

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