Anti-Inflammatory Effects of<i>Hyptis albida</i>Chloroform Extract on Lipopolysaccharide-Stimulated Peritoneal Macrophages

Miranda, Elizabeth Sánchez; Ramos, Julieta; Orozco, Cristina Fresán; Sánchez, Miguel Angel Zavala; Gutiérrez, Salud Pérez

doi:10.1155/2013/713060

Cited by 9 publications

(4 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…During inflammation, matrix metalloproteinases (MMPs) are also induced and are important for regulating immune cell development, effector function, migration and ligand–receptor interactions, as well as activating signal transduction pathways [ 78 ]. Due to these modulations, the LPS-induced model is excellent for the screening and subsequent evaluation of potential drugs or natural products on the inflammatory pathway [ 79 ]. LPS induction causes endotoxemia, which is related to a significant increase in cardiac dysfunction [ 80 ], triggered via toll-like receptor 4 (TLR-4)-mediated inflammatory responses.…”

Section: Anti-inflammatory Actions Of Squalenementioning

confidence: 99%

Interdependence of Anti-Inflammatory and Antioxidant Properties of Squalene–Implication for Cardiovascular Health

Ibrahim

Mohamed

2021

Life

View full text Add to dashboard Cite

Cardiovascular diseases (CVD) have been recognized as the leading cause of mortality worldwide, accounting for 31% of global mortality. Among the risk factors of CVD, hyperlipidemia has been established as the most potent risk factor. Statins, a class of drug that reduces lower-density lipoprotein cholesterol (LDL-C), are the preferred medical treatment. However, due to the development of statin-associated muscle symptoms, statins are associated with patients’ discontinuation and nonadherence. Other statin-induced side effects, such as hepatotoxicity and gastrointestinal upset, all contribute to patients choosing alternative medicines. Squalene (SQ), an unsaturated hydrocarbon naturally synthesized in plants and animals, could become the alternative treatment or supplementary agent for cardiovascular health. SQ has been shown to exert cardioprotective effect via its antioxidant activity. Oxidative stress and inflammatory responses are closely related to each other, which proposes an interdependence relation between antioxidant and anti-inflammatory. Therefore, this review explores the interdependence between the antioxidant and anti-inflammatory effects of SQ implicated on cardiovascular health.

show abstract

Section: Anti-inflammatory Actions Of Squalenementioning

confidence: 99%

Interdependence of Anti-Inflammatory and Antioxidant Properties of Squalene–Implication for Cardiovascular Health

Ibrahim

Mohamed

2021

Life

View full text Add to dashboard Cite

show abstract

“…Importantly, matrix metalloproteinases (MMPs) regulate aspects of immune cell development, effector function, migration and ligand-receptor interactions and activate signal transduction pathways that control cytokine biosynthesis and direct systemic inflammation or barrier immunity. For this reason, the stimulation with LPS constitutes an excellent model for the screening and subsequent evaluation of the effects of candidate drugs on the inflammatory pathway (Sanchez Miranda, Perez Ramos, Fresan Orozco, Zavala Sanchez, & Perez Gutierrez, 2013). Therefore, we investigated the anti-inflammatory activity of squalene on LPS-stimulated murine peritoneal macrophages and human blood monocytes and neutrophils.…”

Section: Introductionmentioning

confidence: 99%

Squalene targets pro- and anti-inflammatory mediators and pathways to modulate over-activation of neutrophils, monocytes and macrophages

Cárdeno

Aparicio‐Soto

Paz

et al. 2015

Journal of Functional Foods

View full text Add to dashboard Cite

A B S T R A C TSqualene is a natural triterpene consumed as an integral part of the human diet. Increasing evidence demonstrates that squalene has antioxidant, cardioprotective and anticarcinogenic activities. Nevertheless, its anti-inflammatory properties remain unclear. The effects of squalene on lipopolysaccharide (LPS)-mediated inflammatory response in murine macrophages and human monocytes and neutrophils were investigated. Squalene reduced intracellular levels of ROS, nitrites, cytokines (TNF-α, IL-1β, IL-6 and IFN-γ) and proinflammatory enzymes (iNOS, COX-2 and MPO), including a decreased expression of TLR4and key proteins for signalling pathways mediated by NF-κB (IκBα), MAPKs (JNK) and MMPs (1, 3 and 9). In addition, squalene enhanced expression levels of anti-inflammatory enzymes (HO-1) and transcription factors (Nrf2 and PPARγ). This study establishes that squalene has significant potential for management of inflammatory conditions characterized by an overactivation of neutrophils/monocytes/macrophages and thereby for the efficient termination of the inflammatory response.

show abstract

“…Hyptis albida ) on inflammatory responses in mouse lipopolysaccharide (LPS) induced peritoneal macrophages were evaluated. The results demonstrated that the extract was able in inhibit LPS-induced production of TNF-α and interleukin-6, signaling molecules in the inflammatory cascade ( Sánchez Miranda et al, 2013 ). Besides, the essential oil of Cantinoa americana (syn.…”

Section: Biological Investigationsmentioning

confidence: 99%

Subtribe Hyptidinae (Lamiaceae): A promising source of bioactive metabolites

Bridi

Meirelles

Poser

2021

Journal of Ethnopharmacology

View full text Add to dashboard Cite

Ethnopharmacological relevance The subtribe Hyptidinae contains approximately 400 accepted species distributed in 19 genera ( Hyptis , Eriope , Condea , Cantinoa , Mesosphaerum , Cyanocephalus , Hypenia , Hyptidendron , Oocephalus , Medusantha , Gymneia , Marsypianthes , Leptohyptis , Martianthus , Asterohyptis , Eplingiella , Physominthe , Eriopidion and Rhaphiodon ). This is the Lamiaceae clade with the largest number of species in Brazil and high rates of endemism. Some species have been used in different parts of the world mainly as insecticides/pest repellents, wound healing and pain-relief agents, as well as for the treatment of respiratory and gastrointestinal disorders. Aim of the review This review aims to discuss the current status concerning the taxonomy, ethnobotanical uses, phytochemistry and biological properties of species which compose the subtribe Hyptidinae. Materials and methods The available information was collected from scientific databases (ScienceDirect, Pubmed, Web of Science, Scopus, Google Scholar, ChemSpider, SciFinder ACS Publications, Wiley Online Library), as well as other literature sources (e.g. books, theses). Results The phytochemical investigations of plants of this subtribe have led to the identification of almost 300 chemical constituents of different classes such as diterpenes, triterpenes, lignans, α -pyrones, flavonoids, phenolic acids and monoterpenes and sesquiterpenes, as components of essential oils. Extracts, essential oils and isolated compounds showed a series of biological activities such as insecticide/repellent, antimicrobial and antinociceptive, justifying some of the popular uses of the plants. In addition, a very relevant fact is that several species produce podophyllotoxin and related lignans. Conclusion Several species of Hyptidinae are used in folk medicine for treating many diseases but only a small fraction of the species has been explored and most of the traditional uses have not been validated by current investigations. In addition, the species of the subtribe appear to be very promising as alternative sources of podophyllotoxin-like lignans which are the lead compounds for the semi-synthesis of teniposide and etoposide, important antineoplastic agents. Thus, there is a wide-open door for future studies, both to support the popular uses of the plants and to find new biologically active compoun...

show abstract

Anti-Inflammatory Effects ofHyptis albidaChloroform Extract on Lipopolysaccharide-Stimulated Peritoneal Macrophages

Cited by 9 publications

References 48 publications

Interdependence of Anti-Inflammatory and Antioxidant Properties of Squalene–Implication for Cardiovascular Health

Interdependence of Anti-Inflammatory and Antioxidant Properties of Squalene–Implication for Cardiovascular Health

Squalene targets pro- and anti-inflammatory mediators and pathways to modulate over-activation of neutrophils, monocytes and macrophages

Subtribe Hyptidinae (Lamiaceae): A promising source of bioactive metabolites

Contact Info

Product

Resources

About