Anti-inflammatory effects of IL-4 and IL-10 on Human Polymorphonuclear Leukocytes

Lee, Sung Woo; Hong, Yun Sik; Chun, Chung Min; Moon, Jun Dong; Kim, Su Jin; Jung, In Chul; Yoon, Young Hoon; Lee, Be An; Moon, Sung Woo; Choi, Sung Hyuk; Moon, Chang-bae

doi:10.3346/jkms.2002.17.1.7

Cited by 28 publications

(23 citation statements)

References 28 publications

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“…50 Both increases and decreases in serum levels of IL-4 have been reported in SLE. 35,51 We did not find any significant difference in the mean levels of IL-4 between the patients and the controls.…”

Section: Discussionmentioning

confidence: 98%

Cytokine imbalance in systemic lupus erythematosus: a study on northern Indian subjects

Arora

Verma

Marwah

et al. 2012

Lupus

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This study showed a distinct profile of cytokine imbalance in patients with SLE from the northern plains of India. The levels, ratios and correlations of cytokines in patients suggested significant deviation from normal. Correlations of cytokines with SLEDAI scores indicated that TNF-α contributes significantly to the pathological manifestations of SLE in patients from the region. A detailed study is warranted.

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Section: Discussionmentioning

confidence: 98%

Cytokine imbalance in systemic lupus erythematosus: a study on northern Indian subjects

Arora

Verma

Marwah

et al. 2012

Lupus

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“…Interleukin‐4 exerts anti‐inflammatory effects on human neutrophils (Lee et al., 2002) and increases neutrophil IL‐1 β production (Crepaldi et al., 2002). Effects of IL‐4 on neutrophil apoptosis have not been reported; however, both Hu et al.…”

Section: Discussionmentioning

confidence: 99%

Use of gene profiling to evaluate the effects of a feed additive on immune function in periparturient dairy cattle

Wang

Puntenney

Burton

et al. 2009

Animal Physiology Nutrition

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Summary Objectives were to investigate mechanisms by which a nutritional supplement alters immunity in dairy cattle. Our hypothesis was that feeding this product to dairy cattle altered neutrophil gene expression. Eight periparturient Jersey cattle were randomly assigned to one of two treatments: control and treated. Control animals were fed a dry cow ration for 1 month prior to calving. The treated cows were fed the same ration supplemented with OmniGen‐AF. Following calving, blood samples were taken and neutrophils were prepared after which RNA was extracted. Gene expression in neutrophils of treated versus control‐fed animals was then assessed using bovine‐total leukocyte (BOTL‐5) arrays. Eighteen genes were differentially regulated in the experimental group and of these, twice as many were up‐regulated as down‐regulated. Patterns of changes indicated that the additive might alter neutrophil apoptosis, signaling and sensitivity. Two of the regulated genes [interleukin‐1β converting enzyme (ICE) and interleukin‐4 receptor (IL‐4R)] were investigated in more detail using quantitative reverse transcriptase‐polymerase chain reaction (QRT‐PCR). Each was found to be elevated by the feeding of experimental product. Increased expression of ICE indicates potential for enhanced neutrophil expression of interleukin‐1β (IL‐1β), a cytokine which plays roles in the inflammatory response and which stimulates adaptive immunity following innate immune activation. Altered expression of IL‐4R indicates potential for changes in neutrophil apoptosis. The experiment identified mechanisms by which the additive altered neutrophil gene expression. While many nutrients support the immune system, we have shown that a non‐traditional nutritional approach may also have utility in modulating immune function.

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“…It has been demonstrated that Th2 cytokines inhibit the TNF-␣/ NF-B system through activation of STAT6 acting as a transcriptional inhibitor of NF-B-dependent gene expression (14). This mechanism could also account for the inhibitory effect of IL-4 on the activation of neutrophils by LPS (15). A complete understanding of how the Th2 cytokines suppress antimicrobial activity of the airway epithelial cells remains to be determined.…”

Section: Discussionmentioning

confidence: 99%

Allergic Airway Inflammation Inhibits Pulmonary Antibacterial Host Defense

Beißwenger¹,

Kändler²,

Hess³

et al. 2006

The Journal of Immunology

109

117

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The innate immune system of the lung is a multicomponent host defense system and in addition has an instructing role in regulating the quality and quantity of the adaptive immune response. When the interaction between innate and adaptive immunity is disturbed, pathological conditions such as asthma can develop. It was the aim of the study to investigate the effect of the allergic inflammation of the lung on the innate host defense during bacterial infection. Human bronchial epithelial cells were preincubated with Th2 cytokines and infected with Pseudomonas aeruginosa. The effect of the Th2 cytokines on the mRNA levels of antimicrobial peptides and the antimicrobial activity of HBEC was determined. To investigate the influence of an allergic inflammation on pulmonary host defense in vivo, mice sensitized and challenged with OVA were infected with P. aeruginosa, and the number of viable bacteria in the lungs was determined together with markers of inflammation like cytokines and antimicrobial peptides. Exposure of airway epithelial cells to Th2 cytokines resulted in a significantly decreased antimicrobial activity of the cells and in suppressed mRNA levels of the antimicrobial peptide human β-defensin 2. Furthermore, mice with allergic airway inflammation had significantly more viable bacteria in their lungs after infection. This was consistent with reduced levels of proinflammatory cytokines and of the antimicrobial peptide cathelin-related antimicrobial peptide. These results show that an allergic airway inflammation suppresses the innate antimicrobial host defense. The adaptive immune system modulates the functions of the pulmonary innate immune system.

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Anti-inflammatory effects of IL-4 and IL-10 on Human Polymorphonuclear Leukocytes

Cited by 28 publications

References 28 publications

Cytokine imbalance in systemic lupus erythematosus: a study on northern Indian subjects

Cytokine imbalance in systemic lupus erythematosus: a study on northern Indian subjects

Use of gene profiling to evaluate the effects of a feed additive on immune function in periparturient dairy cattle

Allergic Airway Inflammation Inhibits Pulmonary Antibacterial Host Defense

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