Anti-inflammatory effects of linalool in RAW 264.7 macrophages and lipopolysaccharide-induced lung injury model

Huo, Meixia; Cui, Xiufang; Xue, Jianming; Chi, Gefu; Gao, Ruijie; Deng, Xuming; Guan, Shuang; Wei, Jiangtao; Soromou, Lanan Wassy; Feng, Hailan; Wang, Dacheng

doi:10.1016/j.jss.2012.10.050

Cited by 180 publications

(132 citation statements)

References 35 publications

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“…Furthermore, the anti-inflammatory activity of lavender essential oil has been reported in several studies. 32,33,[58][59][60] . It has been demonstrated that linalool and linalyl acetate, the inflammation through different pathways.…”

Section: In-vitro Anti-inflammatory Properties Of the Nanofibersmentioning

confidence: 99%

“…31 It has been demonstrated that its main components (linalool and linalyl acetate) are responsible for the anti-inflammatory activity. 32,33 Moreover, LO possesses antibacterial and antifungal properties, 28,34,35 pointing out its efficacy against Staphylococcus aureus that is the bacterium mostly responsible for burn wound infections. 36 Electrospun nanofibers of Polyacrylonitrile (PAN) containing lavender oil have been recently developed for antibacterial and drug delivery applications.…”

Section: Introductionmentioning

confidence: 99%

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Alginate–lavender nanofibers with antibacterial and anti-inflammatory activity to effectively promote burn healing

et al. 2016

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This is an Accepted Manuscript, which has been through the Royal Society of Chemistry peer review process and has been accepted for publication.Accepted Manuscripts are published online shortly after acceptance, before technical editing, formatting and proof reading. Using this free service, authors can make their results available to the community, in citable form, before we publish the edited article. We will replace this Accepted Manuscript with the edited and formatted Advance Article as soon as it is available.You can find more information about Accepted Manuscripts in the Information for Authors. One of the current challenges in wound care is the development of multifunctional dressings that can both protect the wound from external agents and promote the regeneration of the new tissue. Here, we show the combined use of two naturally derived compounds, sodium alginate and lavender essential oil, for the production of bioactive nanofibrous dressings by electrospinning, and their efficacy for the treatment of skin burns induced by midrange ultraviolet radiation (UVB). We demonstrate that the engineered dressings reduce the risk of microbial infection of the burn, since they stop the growth of Staphylococcus aureus. Furthermore, they are able to control and reduce the inflammatory response that is induced in human foreskin fibroblasts by lipopolysaccharides, and in rodents by UVB exposure. In particular, we report a remarkable reduction of pro-inflammatory cytokines when fibroblasts or animals are treated with the alginate-based nanofibers. The down-regulation of cytokines production and the absence of erythema on the skin of the treated animals confirm that the here described dressings are promising as advanced biomedical devices for burn management.

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Section: In-vitro Anti-inflammatory Properties Of the Nanofibersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Alginate–lavender nanofibers with antibacterial and anti-inflammatory activity to effectively promote burn healing

et al. 2016

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“…Nessa espécie, um dos componentes químicos majoritários no óleo essencial é o linalol (Henriques et al, 1997), composto muito utilizado pela indústria da alta perfumaria (Letizia et al, 2003) que o considera um ingrediente floral insubstituível. Além disso, pesquisas evidenciam diversas atividades farmacológicas desse componente, inclusive ação antimicrobiana (Park et al, 2012), anti-inflamatória (Huo et al, 2013), antidepressiva (Guzmán-Gutierrez et al, 2012) anticonvulsionante (Elisabetsky et al, 1999) e vasorrelaxante (Anjos et al, 2013).…”

Section: /10unclassified

Myrtaceae na Bacia do Rio Caveiras: Características Ecológicas e Usos Não Madeireiros

et al. 2016

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RESUMOObjetivou-se descrever o padrão florístico-estrutural, as características ecológicas e os potenciais das Myrtaceae na bacia hidrográfica do Rio Caveiras. As comunidades de Myrtaceae estudadas localizam-se no Planalto Sul Catarinense, Lages, São José do Cerrito e Urupema. Foram instaladas quatro blocos por município, totalizando 30 mil m 2 de área amostral, nos quais todos os espécimes de Myrtaceae com diâmetro à altura do peito (DAP) ≥ 5 cm foram amostrados. A estrutura da comunidade de Myrtaceae foi avaliada pelos descritores fitossociológicos e a suficiência amostral foi verificada utilizando-se o método de rarefação. As abordagens ecológicas e indicações de uso não madeireiro basearam-se em bibliografia especializada e base de dados científicos. Foram amostrados 1.480 exemplares de Myrtaceae pertencentes a 21 espécies e 11 gêneros. As espécies mais abundantes foram Myrceugenia euosma, Siphoneugena reitzii e Myrcia palustris, as quais representaram mais de 50% da estrutura da comunidade. Quanto à classificação ecológica, destacou-se o grupo das secundárias iniciais (57%). As espécies amostradas são indicadas para restauração de áreas alteradas, usos ornamentais (100%) e fitoterápicos (60%). Apesar da representatividade e potencialidades das Myrtaceae, ainda são necessárias pesquisas para embasar a conservação via plano de manejo.Palavras-chave: classificação ecológica, restauração de áreas alteradas, uso fitoterápico. Myrtaceae in the Caveiras River Basin: Ecological Characteristics and Non-timber Uses ABSTRACTThis study aimed to describe the floristic-structural pattern, ecological characteristics and potentials of Myrtaceae in the Caveiras River Basin. The studied Myrtaceae communities are localized in Santa Catarina Southern Plateau -municipalities of Lages, São José do Cerrito and Urupema. Four sampling units were installed in each municipality, totaling a sampling area of 30,000 m 2 . All Myrtaceae individuals with DBH ≥ 5 cm were surveyed within the sampling units. The Myrtaceae community structure was assessed through phytosociological descriptors and the sampling sufficiency was verified using the rarefaction method. The ecological approach, as well as the indication of non-timber use of Myrtaceae resources was inferred from a specialized bibliography and scientific database. 1,480 Myrtaceae individuals were sampled, totaling 21 species and 11 genera. The most abundant species were Myrceugenia euosma, Siphoneugena reitzii and Myrcia palustris, which represent more than 50% of the community structure. Regarding the ecological classification, the late secondary group was the most expressive (57%). The sampled

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“…Aflatoxin B1, a well-known hepatocarcinogen, Majority of results concerning the effects of lavander in different model systems was obtained with lavander oil or with some of the major components of L. angustifolia. Lavander essential oil, volatile aromatic oily liquids isolated from Lavandula plants, possesses many therapeutic properties including antioxidant [38], anti-inflammatory [39], antimicrobial [38,40], antiplatelet and antithrombotic [41], antimutagenic [42] and chemopreventive [40,43] activities.…”

Section: Salvia Officinalis Salvia Officinalis L (Common Sagementioning

confidence: 99%

“…Lavander main components, linalool and linalyl acetate, showed no mutagenic potential in Ames mutagenicity test, with or without metabolic activation [48], and linalool did not induce chromosomal aberrations when incubated with Chinese hamster ovary cells [49]. Besides, Huo et al [39] investigated protective effects of linalool on inflammation in LPS-stimulated RAW 264.7 cells and in LPS-induced in vivo lung injury model. They demonstrated that linalool significantly decreased LPS-induced production of proinflammatory cytokines (tumor necrosis factor-α and interleukin-6) in vitro and in vivo.…”

Section: Salvia Officinalis Salvia Officinalis L (Common Sagementioning

confidence: 99%

Biological effects of four frequently used medicinal plants of Lamiaceae

Srančíková¹,

Horvathova²,

Kozics³

2014

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Cancer is one of the leading causes of death characterized by uncontrolled growth and spread of cancer cells. There are several hundred thousands of new cases of cancer worldwide. Clinical oncology is still challenged by toxicity and side effects of multimodal therapy strategies in which it is associated with poor prognosis for patients. There is an urgent necessity to develop novel therapy strategies and to utilize preventive potential of natural compounds. As the majority of anticancer drugs are of natural origin, natural products represent a valuable source for the identification and development of novel treatment options and chemopreventive mechanisms for cancer. This review is focused on the summary of published knowledges on the antioxidant and potential chemopreventive effects of biologically active substances present in the extracts of four plants of the family Lamiaceae (sage, thyme, rosemary and lavander) in different animal and in vitro systems. It is assumed that the chemopreventive and chemotherapeutic potential of natural compounds is the result of a combined action of several mechanisms.

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Anti-inflammatory effects of linalool in RAW 264.7 macrophages and lipopolysaccharide-induced lung injury model

Cited by 180 publications

References 35 publications

Alginate–lavender nanofibers with antibacterial and anti-inflammatory activity to effectively promote burn healing

Alginate–lavender nanofibers with antibacterial and anti-inflammatory activity to effectively promote burn healing

Myrtaceae na Bacia do Rio Caveiras: Características Ecológicas e Usos Não Madeireiros

Biological effects of four frequently used medicinal plants of Lamiaceae

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